OncoVITA products

Oncovita’s Measovir^TM proprietary platform relies on a DNA plasmid vector that expresses a modified measles Schwarz virus antigenome able to generate recombinant viruses by using a clonal reverse genetics system. This versatile plug-and-play platform allows producing new viruses expressing very large amounts of additional genetic material.

Measles live attenuated virus is one of the safest and most efficacious human vaccines that saves 2-3 million babies’ lives each year. The virus was attenuated in the 60s by serial passages on chicken cells giving rise to several attenuated strains among which the Schwarz strain is the most attenuated and widely used in human preventive medicine

Engineered viruses have proven to be powerful “bullets” to target cancer cells and to promote their immunogenic death. Oncolytic viruses are replicative viruses that preferentially infect tumor cells while preserving healthy cells. Some of them, in particular the measles virus, exhibit immuno-adjuvant properties that reinforce the antitumor immune response by breaking immune tolerance to the cancer.