Profacgen articles

Introduction

Cellular mechanisms driving cell death play a crucial role in various physiological and pathological processes. One such mechanism is apoptosis, a tightly regulated process vital for maintaining tissue homeostasis, development, and immune response. Apoptosis assays are valuable tools used by researchers to study the intricate details of this cellular event. This blog aims to provide

Introduction

In the world of molecular interactions, understanding the forces that drive binding events is crucial for advancing scientific research and developing new therapies. One powerful technique that has revolutionized the study of molecular interactions is Microscale Thermophoresis (MST). In this blog post, we will delve into the world of microscale thermophoresis, exploring its applications, advantages,

Drug development is a balancing act between ensuring that the drug is suitable for the target and that the drug can penetrate the cell membrane to reach the target. Typically, research into drugs that can cross cell membranes has focused on small, rigid molecules with nonpolar chemical structures. However, new therapeutic strategies break traditional drug design rules by using larger, flexibly linked chemical entities.

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Longlong Si's research group from the Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, published a research titled "Generation of a live attenuated influenza A vaccine by proteolysis targeting" in Nature Biotechnology. Using influenza virus as a model virus, the team established the technology of protein degradation targeting virus as an attenuated vaccine (Proteolysis-Targeting Chimeric virus vaccine, PROTAC vaccine), which provides new

Targeted protein degradation (TPD) technology is a new technology that specifically recognizes the target protein and directly degrades the target protein using the inherent protein degradation pathway in the cell. At present, technologies such as PROTACs, molecular glues, degradation tags, lysosome-targeted chimeras, and autophagosome-binding compounds have been developed in the field of TPD, which greatly expands the range of degradable target proteins.

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Genetic mutations in cells are an important cause of cancer development, progression, and drug resistance. How to quickly and accurately translate massive tumor genomic information into safe and effective cancer targeted therapies in clinical practice is a scientific frontier today. At present, a large number of scientific studies have focused on how oncogenic mutations regulate the activity of proto-oncogene protein products themselves. However, whether amino acid residues formed by genetic

In the evolutionary history of vertebrates, the emergence of myelin has made the transmission of neural signals much faster, and if humans evolve like invertebrate squid, the vertebral diameter of humans may be thicker than that of giant red fir trees. Insulating myelin sheaths encapsulate nerve axons, thereby allowing rapid conduction of action potentials between neurons, and in addition, myelin sheaths can also provide metabolic support, physical protection, and trophic factors for neuronal

Multiple myeloma is an essentially incurable plasma cell cancer with a very poor prognosis for patients; however, in a recent study published in Science Translational Medicine entitled "Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the protein CD98 heavy chain," scientists from Osaka University in Japan have discovered the CD98 heavy chain, a common component of a common amino acid transporter, which may represent an effective monoclonal antibody with pr

Recently, the Wolf Foundation published a list of Wolf Chemistry Award winners in 2022, with honors from Professor Bonnie L. Bassler at Princeton University, Professor Carolyn R. Bertozzi at Stanford University, and Professor Benjamin F. Cravatt III at the Scripps Institute. The press release points out that these scientists have made pioneering contributions to understanding the chemistry behind cellular communication, as well as inventing chemical methods for studying the role of carbohydra

The mode of action of currently developed drugs is mostly to achieve the purpose of disease treatment by inhibiting or enhancing the activity of target proteins. However, these drugs have to bind to the active site of target proteins to work. Among the known drug target proteins, only about 20% of the target proteins contain bindable active site, and 80% of the target proteins are non-druggable targets. How to develop drugs by acting on the vast majority of non-druggable targets has become th