12 Articles found
Profacgen Articles
-
Co-Immunoprecipitation (Co-IP): A Comprehensive Guide
Introduction Co-immunoprecipitation (Co-IP) is a versatile and powerful laboratory technique employed to elucidate protein-protein interactions. It is particularly valuable for identifying and characterizing protein complexes involved in ...
-
Unlocking the secrets of cellular uptake: paving the way for new cancer and disease treatments
Drug development is a balancing act between ensuring that the drug is suitable for the target and that the drug can penetrate the cell membrane to reach the target. Typically, research into drugs that can cross cell membranes has focused on ...
-
New Approaches to Label Proteins Help Track Disease
Scientists at the Francis Crick Institute and Imperial College London have developed a new way to study proteins released by cells, which may spawn new tools to track diseases, including cancer. Biomarkers are invaluable tools that enable ...
-
Nature Biotechnology: Generation of a live attenuated influenza A vaccine by proteolysis targeting
Longlong Si's research group from the Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, published a research titled "Generation of a live attenuated influenza A vaccine by proteolysis targeting" ...
-
How Much Do You Know about Targeted Protein Degradation Drugs?
Targeted protein degradation (TPD) technology is a new technology that specifically recognizes the target protein and directly degrades the target protein using the inherent protein degradation pathway in the cell. At present, technologies such as ...
-
Mutation-directed Neo-protein-protein Interactions in Cancer
Genetic mutations in cells are an important cause of cancer development, progression, and drug resistance. How to quickly and accurately translate massive tumor genomic information into safe and effective cancer targeted therapies in clinical ...
-
Discovery of Pathways that Promote Remyelination
In the evolutionary history of vertebrates, the emergence of myelin has made the transmission of neural signals much faster, and if humans evolve like invertebrate squid, the vertebral diameter of humans may be thicker than that of giant red fir ...
-
Possible treatment of human multiple myeloma found
Multiple myeloma is an essentially incurable plasma cell cancer with a very poor prognosis for patients; however, in a recent study published in Science Translational Medicine entitled "Selective targeting of multiple myeloma cells with a monoclonal ...
-
Three scientists won the Wolff Chemistry Award 2022
Recently, the Wolf Foundation published a list of Wolf Chemistry Award winners in 2022, with honors from Professor Bonnie L. Bassler at Princeton University, Professor Carolyn R. Bertozzi at Stanford University, and Professor Benjamin F. Cravatt III ...
-
Research Progress of Targeted Protein Degradation Technology
The mode of action of currently developed drugs is mostly to achieve the purpose of disease treatment by inhibiting or enhancing the activity of target proteins. However, these drugs have to bind to the active site of target proteins to work. Among ...
-
Comprehensive protein interaction network helps discover candidate drugs for the treatment of COVID-19
Treatment options for COVID-19 remain limited. Researchers at the University of Helsinki and the University of Eastern Finland first searched for appropriate drug targets and reusable drugs and finally discovered six candidates with antiviral ...
-
Ideal COVID-19 Vaccine May Come from Alpacas, New Study Found
In response to the COVID-19 caused by the new coronavirus (SARS-CoV-2), there are currently many vaccines on the market worldwide. However, despite the fact that major manufacturers are working hard to produce vaccines, the speed of vaccination ...