Pureims B.V. products

Colistin Cyclops™ is a pre-filled colistin dry powder inhaler for the treatment of pulmonary Pseudomonas aeruginosa infections in cystic fibrosis and bronchiectasis. It offers a more patient-friendly alternative to other methods of administering colistin, because it is easy to use, easy to carry, pre-filled and disposable (no cleaning required!).

In addition to in-house programs, we aim to co-develop products with partners who are pursuing NCEs and/or repurposed medicines for local or systemic application. In this respect, PureIMS collaborates with several companies. PureIMS has GMP facilities for the clinical-scale manufacturing of Cyclops™-based products. The Cyclops™-formulation process is scalable and the company has built good relationships with several major developers of market-scale production lines.

Epinephrine Cyclops™ is a pre-loaded disposable breath-powered epinephrine dry powder inhaler for the fast and reliable treatment of severe allergic reactions and anaphylaxis. Inhaled epinephrine from the Cyclops™ offers people at risk of anaphylaxis a low barrier to use, because it is non-invasive, easy and convenient to handle, it has a fast onset of action, and a short exposure duration which allows for repeated treatment without dose stacking. Epinephrine Cyclops™ is more affordable than epinephrine auto-injectors and its credit card size enables excellent portability of one or more devices. This allows patients to have multiple devices per user. It also allows for the disposable nature of Epinephrine Cyclops™. Disposable inhalers are ideal for incidental acute treatment of anaphylaxis. 

Amikacin Cyclops™ is an amikacin dry powder inhaler for the treatment of tuberculosis (TB). Inhaled amikacin from the Cyclops™ will result in higher amikacin concentrations in the lungs than conventional infusion or intramuscular injection. This could more rapidly decrease contagiousness by sterilizing the upper airways of patients with ’open’ (smear positive) TB, potentially even of otherwise drug resistant TB. In addition, Amikacin Cyclops™ offers TB patients an easier and much more convenient administration than infusion or injection. A fast reduction of contagiousness and new, less toxic drug regimens with a shorter duration will prevent long hospital admissions and thereby help to reduce healthcare costs.

Levodopa Cyclops™ is a levodopa dry powder inhaler for the fast and reliable relief of OFF episodes in Parkinson’s disease. As such, Levodopa Cyclops™ answers a major unmet medical need. Levodopa is the cornerstone in the treatment of Parkinson’s disease for well over 50 years. It is the most effective, safe and well tolerated drug available to this end. However, patients suffering from Parkinson’s disease invariably will encounter a major unmet medical need as the disease progresses: Patients in mid- and late-stage disease suffer from variable therapeutic efficacy, which results in periodic motor-fluctuations (ON and OFF episodes). Patients with acute OFF episodes need fast and reliable rescue therapy to be able to participate in daily activities. Currently available medication either has a slow or unpredictable onset of action or is poorly tolerated and uncomfortable to use.