9 services found
Synbio Technologies LLC Services
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Antibody Discovery Services
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Immune Repertoire Sequencing Services
Immune Repertoire refers to the set of all functionally diversified B cells and T cells in the circulatory system of an individual at any given time. Immune repertoire sequencing (Immuno-Seq) targets at T/B lymphocytes and utilizes the 5’ Rapid Amplification of cDNA Ends (RACE) Technology. The 5’ RACE technology amplifies complementarity-determining regions (CDRs) of B cell receptors (BCRs) or T cell receptors (TCRs). The CDRs are targeted ...
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Hybridoma/Monoclonal Antibody Sequencing Services
Obtaining the hybridoma monoclonal antibody (mAb) sequence is one of the key requirements of recombinant antibody engineering. Synbio Technologies provides both accurate and efficient monoclonal antibody sequencing services. To accomplish this, we utilize special primer sets and advanced sequencing techniques to help our customers save on research costs and increase overall efficiency. In doing so, we allow our customers to accomplish their downstream ...
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Bioinformatics Analysis of Antibody Sequencing Data Services
Accurately acquiring antibody sequences is one of the most important prerequisites to achieving antibody functional optimization and expression of recombinant engineering antibodies. Antibody sequencing and analysis also plays a key role for researchers publishing articles and apply for patents. The data is even more critical for pharmaceutical enterprises to further their research and develop novel drugs. Synbio Technologies can quickly and accurately ...
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Antibody Design and Production Services
In recent years, the proportion of biological drugs in the global pharmaceutical market has been close to 20%. The focus within the global pharmaceutical market has been gradually shifting from small molecule chemical drugs to biomacromolecules (biological drugs). It also appears that the trend is gradually expanding. Biological drugs are a broad class of pharmaceuticals generated by using principles and methods of biology, immunology, physical ...
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Custom Monoclonal Antibody Preparation Services
Hybridoma technology features the effective usage of innate functions of both immune and cancer cells to generate monoclonal antibodies (mAbs). The resulting hybridoma cell lines are produced to combat specific antigens of interest. Such technology has forged remarkable new approaches toward therapeutic mAb discovery, as well as disease diagnosis and ...
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Antibody Humanization Service
Immunogenicity or Human Anti-Mouse Antibodies (HAMA) response is what happens when antibodies derived from xenogeneic sources are administered to humans. This can potentially decrease the effectiveness of immune-treatment through rapid clearance of the therapeutic antibody or immune-conjugate. In some cases, the patient may even develop an allergic sensitivity and be at risk of anaphylactic shock upon any future treatment containing these ...
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Antibody Affinity Maturation Service
The binding affinity of an antibody is one of the key parameters to determine the efficacy and dosage of an antibody drug. Currently, the methods for improving the binding affinity of antibodies mainly focus on site-mutation, CDR rearrangement, DNA recombinant, etc. With our unique and effective affinity maturation technology, we can quickly spot the key amino acid site in antibody domain. This, in turn, increases the binding affinity of the antibody, ...
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Single Domain Antibody (sdAb) Service
Complex structures and high production costs associated with monoclonal antibodies (mAbs) have limited their achievable clinical applications. For this reason, scientists focusing on antibody drug discovery have shifted their interests toward recombinant antibody ...
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Single B Cell Antibody Service
The immune system is a very robust “antibody factory” that consistently produces antibodies to fight infections and diseases by recognizing and targeting infected cells or pathogens (antigens). The emergence of single B cell antibody technology has enabled a new strategy for discovery of naturally occurring antibody drugs. The single B cell antibody technology produces higher throughput and higher coverage than the conventional hybridoma or ...