ViGeneron GmbH products

REVeRT, Reconstitution via mRNA trans-splicing, is our next generation vector platform for transfer of large genes. Messenger RNA (mRNA) splicing is a very efficient cellular process for the seamless ligation of adjacent protein coding sequences, thereby enabling the formation of a functional gene product. The splicing process, which normally takes place on a single pre-mRNA molecule (cis-splicing), can also be used to ligate two separate mRNA molecules. The latter is referred to as mRNA trans-splicing and is the basis of ViGeneron’s REVeRT technology.

vgAAV, ViGeneron’s proprietary AAV Vector platform, is our next generation vector platform based on novel engineered AAV capsids. In a unique in vivo directed-evolution approach we generated our vgAAV vectors. The vgAAV vector platform enables a superior transduction of target cells and is designed to efficiently cross biological barriers. These attributes allow vgAAV vectors to target a broad spectrum of cell types in the retina, thus enabling intravitreal, less invasive treatment administration. vgAAV’s capability to cross biological barriers makes vgAAVs also attractive tools for applications beyond ophthalmology.