AROTEC - Model ATT01 - Tissue Transglutaminase (tTG) - Brochure

tTG is the most widely distributed member of the transglutaminase family, being expressed in almost all cell types. Belonging to a family of calcium dependent enzymes it has been found to be expressed in up to 8 different isoforms, depending on its loci within tissues. Enzymatically tTG is known to play a role in tissue repair, specifically in remodelling functions whilst also exhibiting protective and preventative properties. The enzyme is 687 amino acids in length with a molecular weight of around 80kDa with 4 domains, an N-terminal beta sandwich domain, catalytic core and 2 C-terminal beta barrel domains.