GeneAb - Model IHC506 - Actin, Smooth Muscle Antibody Datasheet

Actin is part of the cytoskeletal system of all cell types. Smooth muscle actin is found in myofibroblasts and myoepithelium, but not in cardiac or skeletal muscles. Labeling of smooth muscle actin in concert with muscle-specific actin staining can allow for differentiation between rhabdomyosarcoma and leiomyosarcoma, as muscle-specific actin is found in rhabdomyoblasts, while smooth muscle actin is found in leiomyosarcomas.