Human MR1 Tetramer Empty (R-PE Labelled) - Datasheet

MHC class I related protein (MR1) molecules are non-polymorphic, non-classical major histocompatibility complex (MHC) molecules that are highly conserved across many mammalian species. The ligand binding groove of the MR1 molecule has been shown to bind small molecules derived from microbial riboflavin biosynthetic pathways and present these to mucosal associated invariant T cells (MAIT cells). MAIT cells are a subset of unconventional T cells thought to play a role in microbial and mucosal immune responses. Presentation of microbial antigens in the context of MR1 leads to activation of MAIT cells, secretion of cytokines and lysis of microbial-infected cells.