InvivoGen - Model PKR - Aminopurine Inhibitor Brochure

2-aminopurine (2-AP) is a potent inhibitor of double-stranded RNA (dsRNA)-activated protein kinase (PKR), a critical mediator of apoptosis. PKR is phosphorylated and activated by dsRNA and poly(I:C) [1] and contributes to the induction of type I interferons, such as IFN-β, which can further increase its expression [2]. PKR plays also a role in TLR-induced antiviral activities as an intermediary in TLR3, TLR4 and TLR9 signaling [3].