Ionpath - Model 150Nd - Arginase-1 Antibody - Brochure

Background:Arginase-1 is expressed by liver cells, myeloid-derived suppressor cells (MDSCs), macrophages, and neutrophils.  In mammals, there are three enzymes that metabolise arginine: two arginase isoforms  (ARG1, ARG2) and inducible nitric oxide synthase (iNOS). Arginase-1 catalyzes the breakdown of L-arginine into L-ornithine and urea as the final step in the urea cycle.  L-arginine is a  necessary metabolite for T cell receptor signaling and T cell proliferation. Arginase is induced by inflammation. In cancer, MDSCs within the tumor microenvironment (TME) produce arginase-1 resulting in low levels of available L-arginine within the TME leading to attenuated T cell responsiveness.