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The BioPlex 2200 ANA Screen with MDSS detects clinically significant antibodies, providing the most relevant information for better diagnosis of systemic autoimmune diseases. Its multiplex technology permits simultaneous detection and identification of many antibodies in a single ...
The BioPlex 2200 ANA Screen with MDSS detects clinically significant antibodies, providing the most relevant information for better diagnosis of systemic autoimmune diseases. Its multiplex technology permits simultaneous detection and identification of many antibodies in a single ...
Providers don’t want to delay patient care. Payers don’t want to waste money on unwarranted, ineffective autoimmune care. Both want to improve clinical outcomes while ensuring healthcare dollars are spent ...
The BioPlex 2200 Celiac IgA kit is a multiplex flow immunoassay for the semi-quantitative detection of IgA autoantibodies to deamidated gliadin peptide (DGP) and tissue Transglutaminase (tTG). In conjunction with clinical findings and other diagnostic tests, the tests are used as an aid in the diagnosis of Celiac ...
Cultures based on cell monolayers have the advantage of reducing tissue complexity to a minimum. However, the lack of normal physiological cell-matrix interactions leads the cell metabolism and gene expression towards a dedifferentiated state. Compared to a monolayer, three-dimensional cultures are associated with a higher cell density, and nutrient supply depends on diffusion through the ...
Chromatically purified mouse monoclonal antibody to the Y-F-V-P-P-K-E-D-F-K epitope of the Scl-70 antigen, Clone 17F2, Isotype IgG, K. For use in standard solid phase immunoassays. ...
Experimental autoimmune encephalomyelitis, an experimental murine model for multiple sclerosis, is induced by stimulation of myelin-specific T lymphocytes. Myelin oligodendrocyte glycoprotein (MOG), a minor component of myelin proteins, is a potent autoantigen which contributes extensively to the anti-myelin ...
AROTEC Diagnostics Limited has been producing and delivering the highest quality, critical components to the autoimmune diagnostic industry since its incorporation in 1996. Based in Wellington, New Zealand, AROTEC has grown over the years to become a valued and trusted supplier of premium reagents to both IVD companies and research and academic groups around the world. AROTEC is a quality-driven ...
The BÜHLMANN GanglioCombi™ MAG ELISA is the ideal and efficient tool to support investigations of autoimmune related peripheral neuropathies. It combines, as unique multiparametric IVD ELISA, MAG and ganglioside antigens on the same profile and thus enables a targeted screening for the most prominent immune-mediated neuropathies. The kit features all enzyme label-conjugates and allows ...
LC-1 is a marker for autoimmune hepatitis (AIH) type II and antibodies against LC-1 are found to be detected in up to 50% of cases. Immunofluorescence of LC-1 is often not identified due to the brightness of LKM-1 obscuring accurate visualisation. Some occurrences of anti-LC-1 in conjunction with antinuclear antibodies (ANA) and smooth muscle antibodies (SMA) in patients with chronic hepatitis C ...
Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen & Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and ...
Jubilant Therapeutics is a NJ based clinical stage precision therapeutics company addressing significant unmet medical needs in oncology and autoimmune ...
Total-IgE Rapid Test is a one-step qualitative immunoassay for the detection of elevated levels of immunoglobulin E (total IgE) in human serum or plasma. This human IgE rapid test is an aid for diagnosis of allergic reactions and autoimmune disorders. ...
Myasthenia gravis (MG) is an autoimmune, slowly progressing neurological condition leading to skeletal muscle weakness (mostly muscles of the eyes and face). It is caused by patient‘s autoantibodies that block or destroy nicotinic acetylcholine receptors (AChR) at the neuromuscular junctions. AChR-autoantibody detection is therefore the most specific marker in the diagnosis of MG. If ...
B-cell activating factor (BAFF), is a TNF superfamily member (TNSF13B) best known for its role in the survival and maturation of B cells. BAFF is produced by several cell types and tissues including monocytes, macrophages, neutrophils, dendritic cells, T lymphocytes, spleen, lymph node, and bone marrow. BAFF plays a role in autoimmune disease disorders and is elevated in the serum of patients ...
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TCR profiling holds great potential not only for understanding the mechanisms of development of the normal immune response, but also in providing insights into disease mechanisms and development of new therapeutics and treatment modalities in infectious diseases, autoimmunity and in immuno-oncology. However, identification of all potential clonotypes in a diverse repertoire of TCRs requires ...
Vitamin D refers to a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, iron, magnesium, phosphate and zinc. Vitamin D is produced by skin exposed to ultraviolet B radiation or obtained from dietary sources, including supplements. Average daily vitamin D intake in the population and current dietary reference intake values are often inadequate to ...
We, Medipan GmbH & GA Generic Assays GmbH (Germany), are leading companies in the development, manufacturing and marketing of IVD assays and instruments. Together, we have an extensive experience in immunochemistry and biomedicine, especially in tissue and cell-based IFA, ELISA and LINE & Dot assays for the diagnosis of rheumatic and other autoimmune diseases with neurologic, vascular, ...
IgE constitutes a fraction of the total antibody in serum 50-300 ng/ml (compared to 10 mg/ml for IgG) and together with its Fc receptor is important in primary immune responses. The immunogenetic mechanisms underlying IgE responsiveness seen in the atopic diseases can be divided into antigen-specific and nonantigen-specific responses. IgE antibodies to common antigens are reported in the serum of ...
Nicole Casadevall, 1, “Epoetin-induced autoimmune pure red cell aplasia,” The Hematology Journal, 2004, 5, 104–1092. ...