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Autoantibodies to centromeric proteins in the sera of patients with scleroderma were first described in 1980. Subsequent studies confirmed that anti-centromere antibodies (ACA) were most often found in patients with a limited form of systemic sclerosis previously referred to as CREST syndrome. These autoantibodies are also often detected in sera from patients with Raynaud’s phenomenon and ...
rst morning urine, however in the course of the day values can vary greatly.2) Extrarenal proteinuria frequently appears with acute diseases like heart insuf?ciency, colics, liver cirrhosis, plasmocytoma, and car-cinomas.3) Renal proteinuria is caused by increased permeability of the glomerular ...