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Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease enzyme associated with the CRISPR (Clustered Regularly Interspersed Palindromic Repeats) adaptive immunity system in Streptococcus pyogenes and other bacteria. ...
Sequencing-based genome editing validation can detect whether alleles of a gene have been edited correctly, identify insertion and deletion sites at the whole-genome level, and screen and identify monoclonal cell lines. In addition,it is an excellent way to study the off-target effects of CRISPR gene editing. ...
Sequencing-based genome editing validation can detect whether alleles of a gene have been edited correctly, identify insertion and deletion sites at the whole-genome level, as well as screen and identify monoclonal cell lines. In addition, it is an excellent way to study the off-target effects of CRISPR gene editing. NGS is a massively parallel sequencing strategy that allows for higher ...
CISH (Cytokine Inducible SH2 Containing Protein) contains a SH2 domain and a SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CISH may be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent ...
The Sherlock™ CRISPR SARS-CoV-2 kit is the first FDA authorized CRISPR-based EUA diagnostic test. The kit is intended for the qualitative detection of nucleic acid from SARS-CoV-2 in upper respiratory tract and bronchoalveolar lavage samples from individuals suspected of COVID-19 by their healthcare provider. This kit provides specific and sensitive identification of ...
eSpCas9 (enhanced specificity Cas9) has enhanced specificity compared to wild type Cas9 for CRISPR/Cas9 genome editing. eSpCas9 is able to reduce off-target effects and maintain robust on-target genome editing efficiency, allowing more efficient gene targeting. eSpCas9 (CAG, Neo) lentivirus expresses eSpCas9 under the control of the CAG promoter with neomycin as a selection marker, allowing ...
Chromium Single Cell Gene Expression provides single cell transcriptome 3' gene expression and multiomic capabilities to profile tens of thousands of cells. Explore cellular heterogeneity, novel targets, and biomarkers with combined gene expression, surface protein expression, or CRISPR edits in each ...