immune response Downloads
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Model VPK-401 - AAV-1 Helper Free Packaging System - Manual
Adeno-associated viruses (AAVs) are derived from defective parvoviruses, which depend on essential helper functions provided by other viruses, such as adenovirus and herpes virus, for efficient viral replication and propagation. AAV has no etiologic association with any known diseases and has been successfully used to establish efficient and long-term gene expression in vivo in a variety of ...
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Vitalize Alimend - Gastric Health and GI Tissue - Datasheet
Amaferm® is a precision prebiotic designed to boost animal resilience to challenges. It is research-prove to improve gut integrity and immune ...
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CD52 - Model FITC - Glycoprotein - Datasheet
Clone CF-1D12 recognizes human CD52, a 21-28 kDa glycoprotein whose C-terminus is glycophosphatidylinositol (GPI) anchored within the membrane. It is also known as Cambridge pathology antigen 1 (CAMPATH-1). Binding of CF-1D12 with CD52 induces a potent complement-mediated cytolytic immune response of matured lymphocytes. It is widely expressed on the surface of thymocytes and mature lymphocytes, ...
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Stemcell - Model IL-2 (CHO-expressed) - Human Recombinant- Brochure
Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen & Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and ...
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Human MR1 Tetramer Empty (R-PE Labelled) - Datasheet
MHC class I related protein (MR1) molecules are non-polymorphic, non-classical major histocompatibility complex (MHC) molecules that are highly conserved across many mammalian species. The ligand binding groove of the MR1 molecule has been shown to bind small molecules derived from microbial riboflavin biosynthetic pathways and present these to mucosal associated invariant T cells (MAIT cells). ...
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Cell Membrane Proteins Perform Important Functions
Cell membrane proteins perform important functions such as exchange of materials and out of the cell, cell recognition and immune response, signal transduction and regulation, and energy transfer. To better understand their functions, it is necessary to reveal the characteristics of membrane proteins and monitor the modification and regulation of their expression. ...
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MHC Tetramer for Other Applications
T cells play essential roles in adaptive immune responses to viruses, bacteria, parasites, tumors, transplanted tissues, allergens and even to self antigens. Applications for using pMHC tetramers are rapidly expanding and include exciting new possibilities for ex vivo cell expansion and for ...
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Membrane Proteomics
Cell membrane proteins perform important functions such as exchange of materials and out of the cell, cell recognition and immune response, signal transduction and regulation, and energy transfer. To better understand their functiond, it is necessary to reveal the characteristics of membrane proteins and monitor the modification and regulation of their expression. ...
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MHC Tetramer for Bacteriology
T cells play critical effector and regulatory roles in adaptive immune responses to bacteria. And MHC Tetramers have been proved to be very effective in identifying antigen-specific T cells by flow cytometry, even those present at low frequencies in fresh populations of lymphocytes sampled directly ex ...
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MHC Tetramer
MHC Tetramers have emerged as an important tool for characterization of the specificity and phenotype of T cell immune response, useful in a large variety of disease and vaccine ...
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AgilePulse - Model ID and IM - In Vivo Electroporation System - Datasheet
Effectively introduced DNA vaccines represent a powerful and safe means for stimulating an immune response that recognizes and eliminates target molecules in the body. However, traditional DNA vaccine delivery systems such as gene gun delivery electroporation suffer from poor efficiency. The BTX AgilePulse In Vivo System provides an intra-dermal/muscular electro-poration solution to produce ...
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Vaccine Storage and Handling Toolkit - Brochure
Proper vaccine storage and handling are important factors in preventing and eradicating many common vaccinepreventable diseases. Yet, each year, storage and handling errors result in revaccination of many patients and signifcant fnancial loss due to wasted vaccines. Failure to store and handle vaccines properly can reduce vaccine potency, resulting in inadequate immune responses in patients and ...
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Vaccine Assays 2024 - Brochure
Immunogenicity assays play a vital role in evaluating the safety and efficacy of vaccines by measuring the immune response induced in vaccinated individuals, and serve as crucial tools in vaccine development, clinical trials, licensure, and post-marketing surveillance. Various methods are employed in vaccine immunogenicity assays, ranging from traditional techniques like LBAs to advanced ...
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Croyez - Model GMP IL - 2 (Interleukin-2), Human Protein - Brochure
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5-16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its ...
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Huabio - Model CX3CR1 -A5C7 HA600074 - Mouse Monoclonal Antibody - Brochure
Monoclonal antibodies (mAbs) are created by immunizing a mouse with a target antigen, thereby eliciting an immune response. The B lymphocytes, taken from the immunized mouse spleen, produce antibodies to the antigen. Each B lymphocyte is then fused with an immortal myeloma cell line, allowing the production of unlimited quantities of antibodies. ...
By Huabio
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MedGenome - TCR Sequencing Service - Brochure
TCR profiling holds great potential not only for understanding the mechanisms of development of the normal immune response, but also in providing insights into disease mechanisms and development of new therapeutics and treatment modalities in infectious diseases, autoimmunity and in immuno-oncology. However, identification of all potential clonotypes in a diverse repertoire of TCRs requires ...
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Mass Spectrometry-based Phosphoproteomics
Phosphorylation plays a critical role in a variety of biological processes, including normal physiology, immune response, disease development, and plant response to stress and hormone expression. https://www.creative-proteomics.com/services/phosphoproteomics-service.htm ...
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Model SARS-CoV-2 IgM ELISA - Vitro Diagnostic Test - Datasheet
The SARS-CoV-2 IgM ELISA kit is an in vitro diagnostic test for the qualitative detection of IgM antibodies to SARS-CoV-2 in human serum. The kit is intended for use as an aid in identifying individuals with an adaptive immune response to SARSCoV- 2, indicating recent or prior ...
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MedGenome - Model OncoPeptTUME - Immunotherapy Drugs - Brochure
OncoPeptTUME — A novel in-silico approach to model the tumor microenvironment and predict treatment efficacy and long-term survival benefits for immunotherapy applications. Cancer immunotherapy is now established as a major therapeutic modality. Cancer immunotherapy drugs elicit their anti-tumor immune response in a subset of the treated patients by activating CD8 T-cells and provide ...
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Protein-Foundry - Model CCL5 - PFP020 - Recombinant Human Protein Cell - Brochure
Human CCL5, also known as Regulated upon Activation, Normal T cell Expressed and presumably Secreted (RANTES), attracts and activates leukocytes and plays a primary role in the inflammatory immune response. CCL5 activates several G protein-coupled receptors including CCRs 1, 3, 4, and 5. CCL5 binding to CCR5 inhibits the infectivity of M-tropic HIV-1 strains. Proteolytic removal of the two ...
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