MedGenome - BCR Sequencing Service - Brochure

It is estimated that there are approximately 10¹⁰–10¹¹ B cells in a human adult. A BCR is composed of two identical heavy chains generated by recombination of V, D and J segments and two identical light chains generated by recombination of V and J segments. Human BCRs undergo recombination at these variable regions, generating a large diverse receptor profile for each cell. Utilizing targeted next-generation sequencing of these variable regions, can provide deeper insights into B-cell differentiation, BCR somatic hypermutation, class switching, and antigen specificity. Major applications of BCR repertoire profiling include diagnostic biomarker discovery, tracking known repertoire sequences and disease diagnosis.