Quantum Blue - Anti-Adalimumab Antibodies Brochure

Over the past two decades great improvements in therapy of chronic inflammatory diseases have been made. The rise of anti TNFα biologics has been a significant step forward to ameliorating disease course and keep inflammations at remission levels for prolonged periods of time. Adalimumab is the first anti TNFα biologic on the market approved for patient self-administration by subcutaneous injections. Patients with suboptimal drug concentrations have worse outcomes than those with adequate drug levels.  Therapeutic drug monitoring (TDM) for adalimumab has a great potential for the management of anti TNF therapy. Patients with subtherapeutic or undetectable drug trough levels may exhibit the presence of anti-drug antibodies (ADA) which diminish the clinically beneficial effect of the drug. Fast detection of ADA supports guidance in the management of anti TNF therapy and allows for rapid adaptations in the treatment regime.