Mitochondria Applications
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LCL-161
LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins. https://www.bocsci.com/lcl-161-cas-1005342-46-0-item-462558.html ...
By Alfa Chemistry based in NY, NEW YORK (USA).
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Potent, Long-Lasting, Infusion Therapy for Patients
Heart failure is a progressive syndrome that begins with a chronic condition that often leads to Acute Decompensated Heart Failure, an unstable condition requiring immediate medical ...
By ViCardia Therapeutics, Inc. based in San Francisco, CALIFORNIA (USA).
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Excitation-Contraction-Energy (ECE) Coupling Analysis for Cardiac Physiology
An electrical stimulation, i.e., action potential initiates cardiac contraction. Intracellular Ca2+-transient couples action potential and cardiac contraction. Cardiac contraction is also coupled to mitochondria that replenish energy (i.e., ATP) and recycle metabolites (ADP and Pi). InvivoSciences analyzes all those parameters to determine drug-induced or genetically driven changes in ECE ...
By InvivoSciences, Inc. (IVS) based in Madison, WISCONSIN (USA).
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Human biology solutions for ADME-Tox sector
Increase clinical translation with Organ-Chips for ADME-Tox assessments. Accurate ADME-Tox profiling of preclinical drug candidates remains a challenge. Preclinical ADME-Tox (Absorption, Distribution, Metabolism, Excretion, and Toxicity) studies are pivotal to predicting human response. However, approximately 30% of drugs fail during human clinical trials due to adverse reactions despite promising preclinical study results, and another 60% fail due to lack of efficacy. As companies broaden the modality toolbox ...
By Emulate based in Boston, MASSACHUSETTS (USA).
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