Medical Drugs Articles | Medical XPRT

Why Choose Oligonucleotide Products and Services from BOC RNA?

DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are essential for all known forms of life. They are the main information-carrying molecules in the cell and constitute the genetic material. DNA is similar to RNA and uses a slightly different set of nucleobases. Nucleobases are also known as bases or nitrogenous bases. Nucleobases are electron-rich heterocyclic aromatic that may also ...

Sep. 14, 2021

By BOC Sciences

Global ADC Drug Overview

In recent years, antibody-drug conjugates (ADCs) have been widely sought after due to their excellent clinical performance and market returns. ADC drugs are composed of three parts: antibody, effector molecule (Payload, usually cytotoxic agent) and linker. Compared with traditional drugs, ADC drugs have obvious advantages in improving targeting and reducing side effects. 1. Global ADC listing ...

Aug. 28, 2021

By BOC Sciences

mRNA Delivery System

RNA is a hydrophilic, negatively charged macromolecule, and its ability to autonomously transmembrane is limited. Therefore, how to efficiently deliver mRNA to the cytoplasm and play a corresponding role is one of the key issues that limit the application of RNA therapy. The wide range of applications of therapeutic mRNA requires efficient and safe delivery methods. An ideal delivery system ...

Aug. 27, 2021

By BOC Sciences

The Reality and Future of Peptide Drugs

It has been said that the 21st century is the century of peptide drugs, and the fate of this substance, which lies between a large protein and a small molecule compound, is bound to be extraordinary. What are peptide drugs? Peptides are a class of compounds made up of amino acids linked by peptide bonds and are chemically active substances commonly found in living organisms. According to the ...

Aug. 24, 2021

By Creative Peptides

CD Genomics Perspective: Sequencing-Based Eukaryote Epigenomics

Unlike prokaryotic cells, eukaryotic cells can regulate gene expression at many different levels. Epigenomic changes are inheritable changes in gene expression and are not caused by changes in DNA sequences. In microbial epigenomics studies, molecular processes influencing epigenomic inheritance have been discovered from microbial eukaryotes such as Neurospora crassa and Schizosaccharomyces ...

Aug. 18, 2021

By CD Genomics

CRISPR Screening Technology Brings More Versatility to High-Throughput Sequencing

Introduction to CRISPR Screen Sequencing CRISPR Screen technology is used for high-throughput screening, allowing a large number of gene mutant cells to be created and a mutant cell library to be screened in various external environments. The relationship between phenotype and genotype can be further evaluated using high-throughput sequencing and bioinformatics analysis. Furthermore, ...

Aug. 12, 2021

By CD Genomics

Structure-based Design of Protein Kinase Inhibitors

Protein kinases are effective anti-cancer drug targets that have been proven in many experiments and facts. Many small molecule protein kinase inhibitors approved by the FDA can be used for cancer treatment. The effectiveness of kinases as targets for other diseases, including neurological disorders, inflammation and metabolic diseases, is also being tested. Human protein kinase consists of more ...

Aug. 11, 2021

By BOC Sciences

Design and R&D of Covalent Drugs

For a long time, electrophilic groups have been a minefield in drug development. Therefore, in the classic medicinal chemistry textbooks of the past, it is always recommended to avoid introducing functional groups such as epoxide, acridine and Michael receptor into the structure of drug molecules, because these functional groups are highly reactive and may interact with a wide range of biological ...

Aug. 8, 2021

By BOC Sciences

What are the ADC drugs?

Antibody-drug conjugates (ADCs) continue to rise at home and abroad, but ADCs are not a new thing. Why has ADC been surging for so many years? What kind of magic power it contains, and what makes its growth path so tortuous? Let's take a brief look at the magical "magic bullet"-ADC. ADC (antibody-conjugated drug) is not a new concept. As early as the early 20th century, the Nobel Prize winner ...

Aug. 2, 2021

By BOC Sciences

Exploring Knowledge Graphs for COVID-19 Drug Discovery

Today, there are only a few therapies approved to treat COVID-19, but while novel therapies can take decades and billions of dollars to develop, are there opportunities to repurpose existing drugs for new therapies? Our latest whitepaper showcases how CAS Knowledge Graphs reveal new connections and insights that identify drugs to potentially repurpose. Drug repurposing is critical for faster ...

Jul. 29, 2021

By Chemical Abstracts Service (CAS)

Temple research finds that tweaking CBD may help it curb pain and opioid use in mice

Doylestown-based Neuropathix is running safety tests required to start clinical trials in humans. The compound may help with neuropathy, a severe type of chronic pain associated with cancer treatment. The next generation of cannabis-inspired medicine might be grown in test tubes instead of greenhouses. Researchers at Temple University have partnered with Doylestown-based pharmaceutical company ...

Jul. 6, 2021

By Neuropathix, Inc.

Introducing Hydropore for Cell Biology & Cell Therapy Research

Developing a scalable and efficient transfection method is crucial in accelerating the discovery, development, and manufacturing of gene-modified cell therapies. Researchers need a reliable alternative that can rapidly and efficiently introduce nucleic acids, proteins and gene-editing complexes into cells for a variety of applications. However, current transfection methods such as ...

Jun. 8, 2021

By Indee Labs

What is GMP?

Hundreds of millions of Americans rely on life-saving and sustaining medications and medical devices every day. Ensuring the drugs and devices that they depend on are not contaminated is critical for the health of the country, and the responsibility of the U.S. Food and Drug Administration (FDA). To address safety concerns in the medical, pharmaceutical, and food industries, the FDA ...

Jun. 1, 2021

By MadgeTech, Inc.

How Medical Studies are Changing the World

The coronavirus pandemic remains one of the top concerns within the United States. However, Johns Hopkins, and other research centers, are actively working to continue medical research in all divisions of medicine and health. Learn the ongoing studies at Johns Hopkins, what issues they are solving and how we can all make a difference. ...

May 11, 2021

By C&A Scientific

Introduction to Microbiomics

Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...

Apr. 18, 2021

By Creative Proteomics

A Brief Guide to Federal GMPs for Dietary Supplements

Ensuring quality, safety, and integrity of the dietary supplements require nutraceutical companies to build a culture of quality and meet compliance with Federal GMPs. Thankfully, the development of advanced technologies has made quality management for nutraceuticals more straightforward than ever. With the increasing popularity of dietary supplements, the concern for quality and safety is also ...

Apr. 14, 2021

By Qualityze Inc

Developing a Robust in Vitro Intestinal Model for Preclinical Candidate Screening of GI Toxicity

Gastrointestinal (GI) issues are common side effects of many drugs. Anticipating such side effects before clinical trials is limited by a lack of effective models for evaluating preclinical candidates for their potential to cause diarrhea, nausea, and other gut-related side effects. With its RepliGut® in vitro human intestinal model, Altis Biosystems is developing a system that could help ...

Apr. 12, 2021

By Altis Biosystems

CBD Oil Clarification and Purification

About CBD Oil clarification and purification Raw hemp extracts contain high concentrations of cannabinoids but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Discover our optimized 2-step filtration and purification solution to remove the unwanted contaminants and ...

Apr. 7, 2021

By Filtrox AG

Novel, Smaller and More Powerful CTLA4 Inhibitors for the Treatment of Solid Tumors

Abstract Immune checkpoint inhibitors (ICIs) have obtained durable responses in many cancers, making it possible to foresee their potential in improving the health of cancer patients. However, immunotherapies are limited at the moment to a minority of patients and there is a need for a better understanding of the basic molecular mechanisms and functions of pivotal immune molecules. Immune ...

Apr. 1, 2021

By Atomwise Inc.

Accurately Recapitulating Environmental Niches in Vitro Models of the Intestine

Advanced microphysiological systems can replicate aspects of intestinal complexity, such as epithelium self-renewal by stem cells in in vitro crypts or the interactions of microbes and intestinal epithelium mediated by a mucus layer. Availability of such models is key to progress in compound screening, disease modeling, and microbiome research. Defining a Niche A niche is a multidimensional ...

Mar. 11, 2021

By Altis Biosystems