Cardiac Devices Articles
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Cytokines: Characteristics, Applications, and Quantitative Analysis
Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. Cytokines play pivotal roles in ...
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Establishment of a Stable Organoid Culture System: Customization and Standardization
Prefix Organoids are miniature organs created in vitro from adult stem cells (ASCs) or pluripotent stem cells (PSCs). They form three-dimensional (3D) tissue-like structures through the self-organization, self-renewal, and differentiation capabilities of stem cells. Compared to traditional two-dimensional (2D) cell cultures or spheroids, organoids closely resemble living organs in terms of ...
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GMP Grade Cytokine Needed for Cell Therapy Manufacturing
GMP growth factors and cytokines designed for therapeutic manufacturing are essential components of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct contact with patients. In fact, cell ...
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Baroreflex Activation Therapy: A Novel Approach for HFrEF Patients
During the webinar, you’ll learn about: Treatment options and unmet needs of HFrEF patients The physiologic rationale of baroreflex activation Barostim therapy overview and clinical evidence overview Appropriate patient selection and real-world experience Important Safety Information CAUTION: Federal law restricts this device to sale by or on the ...
By CVRx
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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Inflammatory Cytokines Profile
Cytokines are classified according to their different roles in the inflammatory response: pro-inflammatory cytokines and anti-inflammatory cytokines. Pro-inflammatory Cytokines Interleukin-1 (IL-1) IL-1 is a proinflammatory cytokine that activates a variety of immune and inflammatory cells and is secreted mainly by monocytes/macrophages, neutrophils and endothelial cells. IL-1 consists of two ...
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An introduction to Congenital Heart Defects
An estimated 2.4 million American children and adults are currently living with congenital heart defects (CHDs). Learn more about different types of CHDs, causes and treatment options. Learning that your child has a CHD can be a scary and overwhelming experience, but it’s important to know that you’re not alone. Nearly 40,000 infants in the U.S. are born each year with CHDs, and ...
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What Are the Cytokines?
Cytokines are a class of small molecule proteins secreted by cells that mediate and regulate immune processes, and they act in an autocrine, paracrine and endocrine manner. More than 200 types of human cytokines have been identified, which can be generally classified into interleukins, interferons, tumor necrosis factors, colony-stimulating factors, chemokines, growth factors, etc. according to ...
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Rani Therapeutics’ $73M IPO will fund upcoming clinical trials
Rani Therapeutics, a San Jose-based company developing a pill to replace medical injections, went public on Friday. According to S-1 filings, shares were estimated to price between $14 and $16 last week. On Friday, shares debuted slightly lower, around $11. Rani raised about $73 million in its debut. Rani’s debut comes amidst a flurry of IPO activity in therapeutics. In 2020, 71 ...
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Exploring Knowledge Graphs for COVID-19 Drug Discovery
Today, there are only a few therapies approved to treat COVID-19, but while novel therapies can take decades and billions of dollars to develop, are there opportunities to repurpose existing drugs for new therapies? Our latest whitepaper showcases how CAS Knowledge Graphs reveal new connections and insights that identify drugs to potentially repurpose. Drug repurposing is critical for faster ...
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First-in-man demonstration of 18-month spatiotemporal stability of active atrial fibrillation source detected by Electrographic Flow mapping in persistent atrial fibrillation
Keywords: atrial fibrillation, catheter ablation, mapping, atrial fibrillation, source, electrographic flow Introduction: Advanced mapping methods for atrial fibrillation (AF) have previously suffered from poor spatiotemporal stability. Electrographic flow (EGF) mapping is a novel technique using computer vision and optical flow smoothing algorithms to avoid this issue. The aim of this ...
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Functional Electrographic Flow Patterns in Patients with Persistent Atrial Fibrillation Predict Outcome of Catheter Ablation
Aims: Electrographic flow (EGF) mapping is a method to detect action potential sources within the atria. In a double-blinded retrospective study we evaluated whether sources detected by EGF are related to procedural outcome. Methods: EGF maps were retrospectively generated using the Ablamap® software from unipolar data recorded with a 64-pole basket catheter from patients who previously ...
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Optical vs EM tracking in Neuronavigation
Computer-aided surgery is used in a daily clinical workflow for safer surgical interventions. Navigation systems work based on a tracking model, which helps in the correlation of a patient’s coordinates to the preoperative or intraoperative digital medical imagery. There are two main types of navigation systems available in the market today. They are the infrared (optical) systems and ...
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Rapid Prototyping Services
What is Rapid Prototyping? Rapid prototyping is a kind of professional manufacturing technology that is used to produce high-quality entity models of three-dimensional designs. Prototypes are useful for design improvements and can be used as stepping stones for comprehensive production or engineering testing. With the silicone rapid prototyping, you can manufacture parts or the products to test ...
By Duch Group
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Velocity characteristics of atrial fibrillation sources determined by electrographic flow mapping before and after catheter ablation
Background: Electrographic-Flow-(EGF)-Mapping is a novel method to identify Atrial Fibrillation (AF) drivers. Sources of excitation during AF can be characterized and monitored. Objective: The aim of this study was to evaluate the correlation between velocity of EGF around a respective AF source and its spatial variability (SV) and stability (SST). Methods: 25 patients with AF were included in ...
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What is Rapid Prototyping?
Rapid prototyping is a kind of professional manufacturing technology that is used to produce high-quality entity models of three-dimensional designs. Prototypes are useful for design improvements and can be used as stepping stones for comprehensive production or engineering testing. With the plastic rapid prototype, you can manufacture parts or the products to test for the component fit and ...
By Duch Group
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Comparing phase and electrographic flow mapping for persistent atrial fibrillation
Background: An increasing number of methods are being used to map atrial fibrillation (AF), yet the sensitivity of identifying potential localized AF sources of these novel methods are unclear. Here, we report a comparison of two approaches to map AF based upon (1) electrographic flow mapping and (2) phase mapping in a multicenter registry of patients in whom ablation terminated persistent ...
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Abstract 9761: Novel Modulators of Low Density Lipoprotein Receptor Metabolism
Abstract Intervention with drugs to reduce Low Density Lipoprotein-cholesterol (LDL-C) has proven to decrease the risk of subsequent cardiovascular events, including mortality. Our goal is to develop novel, small molecule, LDL-C lowering drugs by targeting the Low Density Lipoprotein Receptor (LDLR) degradation pathway, which is modulated by the protease proprotein convertase subtilisin-like ...
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Identification of active atrial fibrillation sources and their discrimination from passive rotors using electrographical flow mapping
Barbara Bellmann 1, Tina Lin 2, Peter Ruppersberg 3, Marit Zettwitz 1, Selma Guttmann 1, Verena Tscholl 1, Patrick Nagel 1, Mattias Roser 1, Ulf Landmesser 2, Andreas Rillig 4 Background: The optimal ablation approach for the treatment of persistent atrial fibrillation (AF) is still under debate; however, the identification and elimination of AF sources is thought to play a key role. Currently ...
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Abstract 15053: New Insights into the Development of the Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists
Abstract Protease proprotein convertase subtilisin-like kexin type 9 (PCSK9) is an important target for the treatment of hypercholesterolemia. PCSK9 is synthesized as a zymogen that undergoes autocatalytic processing and secretion. Secreted PCSK9 binds to the LDL-receptor (LDLR) and chaperones it to the degradation pathway. Several pharmaceutical companies have developed injectable mAb PCSK9 ...
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