Hospital Laboratory Articles
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Clinical Research On-Demand: How the University of Washington’s Theberge Lab is Using Tasso to Study Unpredictable Events in Real Time - Case Study
Many important research questions cannot be studied under controlled circumstances. Events like natural disasters or disease exposure often occur without warning and prevent in-person clinic visits, making timely observation difficult without a flexible approach. At the University of Washington, researchers are partnering with Tasso to study these scenarios by deploying on-demand remote ...
By Tasso, Inc.
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Island Hybrid System - Case Study
Islands in many cases have an unreliable grid which forces businesses to rely on alternate forms of energy such as diesel generators for backup. This increases the high electricity cost even more since the cost of diesel is volatile and increasingly expensive. Diesel costs € 1.50 /liter today which produces up to 4kWh of electricity which results in a price of € ...
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Detecting Fusion Transcripts by RNA Sequencing in Screening Tumors
What is fusion gene? What is Chimeric RNAs? A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors. For example, in chronic granulocytic leukemia, ...
By CD Genomics
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How Does SDS-PAGE Work?
Electrophoresis is a major technique for separating proteins and other substances such as nucleic acids, purines, pyrimidines, some organic compounds, and even inorganic ions. Most of the current electrophoresis is to separate the sample into the mobile phase in an immobilized medium. Polyacrylamide gel is one of the main media. It is a porous gel whose pore size is close to the size of protein ...
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Protein-Protein Interaction Identification Method—Co-immunoprecipitation (Co-IP) and Pull-Down
Proteins control all biological systems in the cell. Although many proteins function independently, most proteins need to interact with other proteins to maintain complete biological activity. Therefore, in order to better understand the function and biological characteristics of intracellular proteins, researchers often need to identify and analyze protein-protein interactions. ...
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Central Maine Medical Center - Case Study
Central Maine Medical Center is a 250-bed hospital in Lewiston, Maine with a busy electrophysiology (EP) lab. The hospital is a Premier member, a part of the Yankee Alliance purchasing network and has been using reprocessed EP devices for several years. While success with single-use device reprocessing has been limited in the past, today, Central Maine is on track to save hundreds of thousands of ...
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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Targeted Region Sequencing in Human Disease Studies and Clinical Care
Introduction to target region sequencing Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers to obtain whole genome or targeted regions of samples. Targeted region sequencing is preferred by ...
By CD Genomics
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What makes decentralisation the future of clinical trials?
With the emergence of COVID-19, Decentralisation of Clinical Trials became necessary to comply with social distancing requirements while carrying out clinical research. Over the past few years, the clinical trial landscape has shifted its focus to patient-centric practices to promote patient engagement. But now as the pandemic is long gone, it is time to reflect on how DCT studies are genuinely ...
By Clinion
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The development of complete personalized treatment plans for colon cancer patients utilizing three gene prediction models.
Background Combination chemotherapy using fluorouracil, leucovorin with or without oxaliplatin (5-FU and FOLFOX) are standard treatment for locally advanced colon cancer. However, about half of the patients developed recurrence. The objective of this study was to use gene profiling to predict treatment efficacy for colon cancer patients (stages 1-3). We developed three prediction models: the ...
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Generating a robust prediction model for stage I lung adenocarcinoma recurrence after surgical resection
Abstract Lung cancer mortality remains high even after successful resection. Adjuvant treatment benefits stage II and III patients, but not stage I patients, and most studies fail to predict recurrence in stage I patients. Our study included 211 lung adenocarcinoma patients (stages I–IIIA; 81% stage I) who received curative resections at Taipei Veterans General Hospital between January ...
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INOVIQ study validates the use of SubB2M as an aid in diagnosing malignant melanoma
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. SubB2M-based immunohistochemistry applications represent a new product opportunity for SubB2M in the $1.9b immunohistochemistry market. INOVIQ Ltd (ASX:IIQ) has successfully completed ...
By INOVIQ Ltd
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Bacteria and Viruses: How They Differ
Bubonic plague, HIV/AIDS and COVID-19 are all examples of pandemics, however, the first is caused by bacteria and the other two are caused by viruses. Both viral and bacterial infections have similar effects on the body. Coughing, sneezing, fever, inflammation, vomiting, fatigue, and so forth are signs that your immune system is working to fight off an infection. While bacteria and viruses ...
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Everything You Want to Know About Horseradish Peroxidase
Peroxidase, usually derived from horseradish, is a common enzyme used in clinical testing reagents. It is widely used not only in several biochemical assays but also in immunoassay (ELISA) kits. As a key component of the color development system of several kits, peroxidase has an important impact on the quality of the kits. Horseradish peroxidase (HRP) is the most commonly used enzyme because ...
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Monlab SL uses iPeak+ to obtain rapid results in drug testing
Monlab SL is a company dedicated to the service of the clinical diagnostic laboratory. They are providing a service according to the needs of hospitals, faculties, research centers, and clinical analysis. One of their business units is the marketing of reliable individual and multipanel blood and urine lateral flow tests. Monlab SL was looking for a reader that would analyze their lateral flow ...
By IUL S.A.
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Automatically Diagnosing HER2 Amplification Status for Breast Cancer Patients Using Large FISH Images
Fluorescence in situ hybridization (FISH) is a technique that prepares acceptable results for molecular imaging biomarkers to precisely and dependably detect and diagnose disorders which are sign of cancers. Since contemporary manual FISH signal analysis is low-effective and inconsistent, it is an attractive research area to develop automated FISH image scanning systems and computer-aided ...
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A Robust Computer-Aided Approach for Scoring and Quantitative Evaluation of Whole Slide Digital Images of HER2 Immunohistochemistry in Breast Cancer
HER2 is recognized as an essential prognostic parameter in breast cancer. Usually interpretation of HER2 negative cases which has no membrane staining or has faint and weak incomplete cells and also positive cases (3+) that consist of strong and complete cell are easy but cells with moderate and weak HER2 staining (2+ or equivocal) require further analysis with fluorescence in situ hybridization ...
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Automated Cell Segmentation and Spot Detection in Fluorescence in Situ Hybridization Staining to Assess HER2 Status in Breast Cancer
Fluorescence in situ hybridization (FISH) approach is constituted of a pair of complementary techniques for precisely detecting gene amplification and over-expression which are regarded as signs of cancer in patients. Signal detection of FISH whole slides is extremely significant as enables to detect amplification situation. However, nuclei detection and segmentation of FISH slides through ...
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Acibadem Hospitals Digital Pathology Project - Case study
Virasoft provides digital pathology systems that optimize the pathology workflow with digital slide management, slide viewing and quantitative image analysis for Acibadem Hospitals pathology laboratories. In partnership with Acibadem Hospitals and Virasoft, artificial intelligence projects are being developed for several cancer diagnosis. Digital Pathology System ViraCenter is an integrated ...
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CD Genomics Perspective: Bioinformatic Analysis for Microbial Metagenomics
Introduction to Bioinformatics for Microbial Metagenomics In microbial ecology, metagenomic techniques are now widely utilized to research microbial communities in greater depth, including many strains that cannot be produced in the lab. Microbial bioinformatics may now be used to mine large metagenomic datasets for broad patterns that govern microbial communities. Typical metagenomic and ...
By CD Genomics
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