Medical Monitoring Articles
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Focal Molography, A Guide Inside Cellular Pathways
Focal Molography, a Guide Inside Cellular Pathways There are billions of cells in our bodies, each with their own characteristics and functions. To function together, cells need to communicate; during the evolution of multi-cellular organisms, cells have developed communication systems of exceptional complexity. These systems govern every level of communication, and together they dictate cell ...
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Significance of Diagnostic Enzyme Detection
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
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How can Nuvonis help to fight the SARS-CoV-2 pandemics?
At the end of the year 2019, a cluster of severe pneumonia of unknown cause was described in Wuhan (Eastern China) and a SARS-like acute respiratory distress syndrome (ARDS) was noted in these patients. Early in January 2020, sequencing revealed a novel coronavirus (now termed SARS-CoV-2) as the causal factor for the disease designated as COVID-19. The pandemic caused by the virus has unforeseen ...
By Nuvonis
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hVIVO used Nuvonis’ GMP Vero cells to produce Novel SARS-CoV-2 virus for a human challenge model
One of the main benefits of using Nuvonis’ fully tested GMP Vero cells is the unparalleled speed towards clinical trials. A case example from one of our customers, hVIVO: First contact with Nuvonis in July 2020, due diligence, contracting, provision of GMP Vero cells and protocols, as well as full documentation Production of GMP material in November 2020 ...
By Nuvonis
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Medical Battery Pack - Most Common Applications
Why Do You Need One? A medical battery pack is an essential part of any medical device. It provides power to the device when no other power source is available. This kinf of battery pack can be used on a number of devices, including portable defibrillators, heart monitors and other life-saving devices. There are many different types of medical battery pack manufacturing on the market today. ...
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What is Label-Free Quantification Technique?
The protein label-free quantification technique analyzes protein enzymatic peptide fragments by liquid-quality coupling and compares the signal intensity of the corresponding peptide fragments in different samples for relative quantification of the protein. This method is not dependent on isotope labeling and does not require expensive stable isotope labels as internal reference. The technique is ...
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Project - Sublingual Exenatide
Liraglutide and exenatide are both belonging to the class of diabetes products called GLP-1 analogues. The GLP-1 analogues have established themselves in the past years as one of the superior drug classes for treatment of diabetes type II in terms of blood glucose lowering and weight loss. Because of the latter, they are being used more and more also in the treatment of obesity. Until now, both ...
By BioLingus AG
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Targeted Region Sequencing in Human Disease Studies and Clinical Care
Introduction to target region sequencing Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers to obtain whole genome or targeted regions of samples. Targeted region sequencing is preferred by ...
By CD Genomics
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Bioinformatics Workflow for Whole Genome Sequencing
Whole genome sequencing (WGS) has the capacity to greatly enhance genomic knowledge and understand mysteries of life by utilizing the most advanced genetic sequencing technologies. WGS can be used for variant calling, genome annotation, phylogenetic analysis, reference genome construction, and more. WGS tries to cover the whole genome, but actually covers 95% of the genome with technical ...
By CD Genomics
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PEG Linkers for Antibody Drug Conjugates
Antibody-drug conjugate (ADC) is one of the fastest growing fields in tumor therapy, which consists of monoclonal antibody (Antibody), linker (Linker) and active drug (Payload). So far, there are only 15 drugs on the market in the world. However, with the development of some perfect antibody modification techniques, advanced site-specific coupling techniques and powerful small-molecule toxins, ...
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Vaccine Freezers for Vaccine Storage and Handling
Vaccine Freezers are required for the safe storage of vaccines that must be kept at extremely low temperatures. Without sufficient storage, a vaccine is likely to form deviations, drastically impacting the vaccines efficiency. At Froilabo we work to support the medical and pharmaceutical industry with the equipment they require to ensure safe storage solutions. Vaccine storage has been in high ...
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Indication selection for anti-PDx combination therapy In collaboration with big pharma - Case Study
The Challenge: One of the most common challenges in immuno-oncology is identifying the indications and patient populations that would benefit from a specific therapy, especially on top of Standard of Care (SOC) treatments. Our platform tackled this challenge of indication prioritization and patient stratification for a combination of a specific target (A) with an anti-PDX drug that one of our ...
By CytoReason
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Identifying a combination benefit of a Ph-3 drug with an SOC drug In collaboration with big pharma - Case Study
The Challenge: To understand the molecular effect of a ph-3 drug (Drug A) which showed moderate outcomes and to recommend next steps to increase response ...
By CytoReason
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Indication prioritization for a CCR6 inhibitor In collaboration with big pharma - Case Study
The Challenge: With a drug in pre-clinical stage, our client was looking for the first indication to go into clinical ...
By CytoReason
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Psylo Leverages CDD Vault to Ramp Up Psychedelic Drug Discovery - Case Study
Psychedelic plants and fungi have been used medicinally by indigenous populations over thousands of years. But while psychedelic drug research has witnessed a relative roller-coaster ride of effort since the mid-20th century, more recent interest in the use of psychedelics for treating mental health and psychiatric disorders has spurred a raft of clinical trials1 . Studies are now evaluating the ...
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Monetizing Medical Data: Zwanger Pesiri Radiology - Case Study
Zwanger Pesiri Radiology is an innovative chain of 32 outpatient radiology centers that stretch across Long Island and New York City. Unlike many groups of imaging centers, they aren’t affiliated with any hospitals and so don’t benefit from hospital reimbursement rates or referrals. ...
By Segmed, Inc.
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Advancing patient care for Japan`s most common cancer - Case Study
Challenge Calculating the appropriate sample size for a first of its kind stage-II colon cancer trial As Chairman of the Department of Biostatistics, Professor Satoshi Teramukai leads a variety of investigator-initiated clinical trials at the Kyoto Prefectural University of Medicine. With over 35 years experience, hundreds of published papers and thousands of citations, Professor Satoshi ...
By Statsol
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Seller beware? Why healthcare organizations are hesitant to sell their data
There are many reasons why healthcare organizations are hesitant to sell their data. For one, they may feel like they are giving up too much control over their data. Once sold, how will they know where it may end up? Will the company that purchases the data turn around and resell it? To what types of companies? How many times? In this blog post, we will explore some of the reasons why healthcare ...
By Segmed, Inc.
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Adaptive Designs in nQuery - Case Study
Effective and Efficient Drug Development Challenge Increased Cost, Risk, and Competition in the Drug Development Processes Dr. Luis Rojas, the Executive Director Head of Biostatistics at Target Health, is a subject matter expert in study design and sample size calculations with more than 30 years of industry experience. He has worked in the leading CROs in the industry and has assisted ...
By Statsol
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Techcomp Products for Medical Marijuana
Medical marijuana uses the chemicals within the marijuana plant to help reduce pain and treat certain diseases. The plant contains more than 100 different chemicals called cannabinoids. Each one has a different effect on the body, with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) being the main chemicals used in medicine.The legality of marijuana for medical use varies by country, in ...
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