Medical Monitoring Articles
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High precision single use temperature recorder for pharmaceuticals
Many drugs are temperature sensitive, and higher or lower temperatures will affect their quality and safety. The storage and transportation of medicines require cold chain management and temperature monitoring. The high-precision single use temperature recorder is very suitable for use in the pharmaceutical cold chain. It has low cost, small space occupation, high accuracy, and meets ...
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Stability Analysis: A Meaningful, Impactful and At-the-Forefront Tool for Pharmaceutical Science
In the field of pharmaceutical science, stability analysis plays a crucial role in ensuring the safety and efficacy of pharmaceutical products. It is a complex and multifaceted process that requires thorough investigation and understanding of various influencing factors. Stability analysis consists of different methods such as influencing factors analysis, long-term accelerated shelf-life ...
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Polymorph, Salt & Cocrystal Screening and Selection
Different solid forms (polymorph, cocrystals and salts) of APIs have significant differences in thermodynamics, kinetics, and physical properties, which may affect the stability, production process, dissolution, and bioavailability of APIs and formulations, and thus may affect the safety, efficacy, and quality controllability of drugs. Therefore, screening and selecting the ideal solid form ...
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Protein Fusion Extends Drug Half-Life Technology
Protein fusion is a genetic recombination technique in which the DNA of an inactive peptide or protein chain segment to be grafted is recombined with the DNA of a drug and expressed together by engineered cells; no specialized grafting operations are required. In the current technology, the inactive peptide or protein chain segment used for protein fusion is the FC region of albumin and antibody. ...
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Exploring a Novel Approach to Asthma Management: Targeting Upstream Live Cell Extrusion
Asthma, affecting over 300 million individuals globally, remains a significant health concern with a high mortality rate. Despite advancements in treatment, many patients still struggle with symptom control and recurrent attacks. While inflammation has been the focal point of asthma research, a recent study sheds light on a mechanical aspect that could refine our understanding and treatment of ...
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Top 4 Things to Know About the Global Sleep Apnea Devices Market
The sleep apnea device market has undergone rapid transformation, driven by growing awareness about the consequences associated with disruptive or poor sleep conditions. Sleep apnea is a severe sleeping disorder in which a person experiences interruptive breathing or loud snoring. Long-term untreated or undiagnosed sleep apnea can cause several health problems, such as daytime sleepiness, ...
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Imaging Complex Cell Morphology: Mesenchymal Stem Cells (MSCs)
MSCs exhibit specific morphology, which makes them unique compared to other cell types typically used in CLD. While forming spindle-shaped, elongated, and transparent cell projections, the MSCs can pose a significant challenge when it comes to imaging and subsequent image analysis. Many imaging systems on the market are simply not fit for precise detection of these unusual cell types. ...
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Karyotype Analysis for Rare Disease
Karyotype analysis refers to the pairing and grouping of chromosomes to reveal whether the organism accords with the inherent chromosomal characteristics, to determine if the organism has chromosomal abnormalities. Karyotype analysis can detect whether there are abnormalities in chromatin length, centromere position, the ratio of long and short arms, and the presence or absence of satellites. ...
By Protheragen
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Evaluation of Anti-Stroke Drugs
Stroke, also known as transient ischemic attack or cerebrovascular accident, is an acute brain disease. Usually, a sudden rupture of a blood vessel in the brain or a blockage of a blood vessel that prevents blood from flowing to the brain can cause damage to brain tissue, resulting in a stroke. Long-term strokes can lead to brain damage, disability and even death. The brain serves as a ...
By Protheragen
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RNA-targeted Gene Therapy
In recent years, various nucleic acid-based therapies (NBT) have emerged as effective and specific activators of endogenous gene expression. Unlike gene therapy approaches supplementing gene expression, RNA-targeted therapy enhances protein production by selectively modulating cellular mechanisms mediated by endogenous RNA, such as transcription, splicing, translation, mRNA stability, and ...
By BOC Sciences
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Comparison and Analysis of SMDC, ADC, and DAC
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the therapeutic index while providing selective delivery. What are their similarities and differences? What are their respective advantages? What is the current status of ...
By BOC Sciences
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3D Printing Technology for Microneedle Preparation
Microneedles have gained significant attention in recent years for their potential in drug delivery applications. These tiny needles, typically measuring less than 1 mm in length, can painlessly penetrate the skin and deliver drugs in a precise and controlled manner. One of the key challenges in microneedle fabrication is achieving high precision and uniformity in needle design, and this is where ...
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Classification of Excipients for Transdermal Drug Delivery System
Transdermal drug delivery system is a type of drug formulation that is absorbed into the body circulation through capillaries at a certain rate through the skin to produce drug effects. Transdermal drug delivery systems allow the drug to continuously diffuse through the skin, penetrate and absorb into the blood circulation, maintain stable blood concentrations for a long time, reduce the ...
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Nanoparticle Development: Revolutionizing Drug Delivery Systems
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific ...
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The Advantages of Exenatide Microneedle Patch Preparation Technology
The backing layer is prepared with the same polymer solution as the needle tip, and polyvinyl alcohol is used as the backing film-forming material to support the microneedle fractions, so that the backing layer has a tight bond with the microneedle tip, and the backing film and the needle tip can be consistently detached from the mold when the film is uncovered, without the problem of process ...
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The Difference Between Span 60 and Tween 60
Span 60 Span 60 is referred to as S60, its main chemical composition is dehydrated sorbitol stearate, the appearance is yellowish waxy solid. Span 60 is an excellent oil-in-water emulsifier with wetting and diffusion properties. It can also be used as a fiber post-processing softener to eliminate static electricity on the fiber to improve softness. Span 60 is harmless to the human body, so it is ...
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Electrospinning Technology of Recombinant Human Collagen
Electrospinning can produce continuous fibers on the micro - and nano-scale. The high flexibility and low cost of the material make electrospinning very attractive. In addition, the high specific surface area, porosity, and similarity to ECM ensure that the electrostatic pad promotes cell adhesion, skin regeneration, nutrient and oxygen transport, moisture retention, exudate removal, and ...
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Understanding the Different Levels of CPR Training
CPR training is more than just a certification; it’s a crucial skill that can save lives in critical situations. In Kentucky, where industries range from manufacturing to healthcare, the demand for comprehensive CPR and first aid training is ever-present. The different levels of CPR training are designed to meet specific needs – from basic techniques for laypersons to advanced ...
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A Closer Look at Reporter Lentiviral Particles: Tool for Biomedical Research
Introduction For years, scientists have leveraged the brilliant potentialities of genetic science to explore how cells function and interact in living organisms. Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the ...
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How to Apply In Vitro DMPK Services to Support Drug Development and ADMET Study
Drug development is a complex and multifaceted process that involves extensive research and testing to ensure safety, efficacy and quality for human use. One critical element in the drug development process is drug metabolism and pharmacokinetics (DMPK), which refers to how a drug is absorbed, distributed, metabolized, and excreted (ADME) from the body. In vitro DMPK services, along with ...
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