Histopathology Articles
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Recent Advances in ADC Linker
The development of antibody-drug conjugates (ADCs) has progressed significantly over the past decade due to improvements in payloads, linkers, and conjugation methods. In particular, linker design plays a key role in regulating ADC stability in systemic circulation and payload release efficiency in tumors, thereby affecting ADC pharmacokinetics (PK), efficacy, and toxicity profiles. Some key ...
By BOC Sciences
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Project - MentorEye
The aim of the project was to develop a Polish complementary system of molecular surgical navigation for the treatment of ...
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The Power of Digital Pathology: Why Labs Everywhere Should Make the Switch
Pathology as it is practiced today in labs around the world is not all that different from the pathology of the 19th century. The microscope has changed relatively little since then, and Hematoxylin and Eosin (H&E) stained slides remain the bread and butter of the pathologist. Yet it is not for lack of technological development; in recent years, digital pathology whole slide scanners, digital ...
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Tips & Tricks to Optimize Your Tissue Processing
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
By Quartzy Inc.
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How Much Do You Know about Bacteriocin?
In recent years, the increase in the number of multi-drug resistant pathogens and food safety have become serious global problems, and it is increasingly important to find or develop a new generation of antibacterial drugs or preservatives. Scientists have discovered that bacteria-produced bacteriocins can control clinically relevant susceptible and resistant bacteria, and purified bacteriocins ...
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How 4D Path and PathPresenter aim to further AI-enabled digital pathology for breast tumor profiling
The digital pathology software company PathPresenter (Montville, New Jersey) and the precision oncology platform firm 4D Path have entered into a partnership that could improve the diagnostic accuracy of breast tumor profiling. PathPresenter has developed a digital workflow tool for clinicians, pathologists and pharma companies to aggregate medical data. ...
By 4D Path Inc.
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A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury
Abstract Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI. Methods: Among fifty-two post-cardiac surgery patients, serum and urine Gal-3 levels were examined on intensive care unit (ICU) admission. In a rat renal I/R ...
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A slide stainer for hematology: IUL’s PolyStainer
Slide staining can be tedious, and guarantee the same standards in quality from the first to the last slide is challenging. To solve this, the automatization of the process can be a solution. However, slide stainers for hematology can be expensive and tricky to use. The haemato-pathologist should ensure a good quality smear, thorough examination, and proper interpretation in line with ...
By IUL S.A.
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Long-term performance of implanted bioprinted human liver tissue in a mouse model of human alpha-1 antitrypsin deficiency
Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of these promising approaches and has ...
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Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies
Abstract Background: Prostate cancer (PCa) diagnosis is challenging because efforts for effective, timely treatment of men with significant cancer typically result in over-diagnosis and repeat biopsies. The presence or absence of epigenetic aberrations, more specifically DNA-methylation of GSTP1, RASSF1, and APC in histopathologically negative prostate core biopsies has resulted in an ...
By MDxHealth
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Enzyme induction and histopathology elucidate AhR vs. non‐AhR mediated effects of aroclor 1268 in American mink (Neovison vison)
Polychlorinated biphenyl (PCB) concentrations reported in preferred prey and blubber of bottlenose dolphins from the Turtle‐Brunswick River Estuary (TBRE, Georgia, USA) suggests the potential for adverse effects. However, PCBs in TBRE dolphins are primarily derived from Aroclor 1268, and predicting toxic effects of Aroclor 1268 is uncertain due to the mixture's unique composition and ...
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A novel framework for interpretation of data from the fish short‐term reproduction assay (FSTRA) for the detection of endocrine‐disrupting chemicals
The fish short term reproduction assay (FSTRA) is a key component of the USEPA endocrine disruptor screening program (EDSP), which uses a weight‐of‐evidence analysis based on data from several assays to identify the potential for chemicals to act as agonists or antagonists of the estrogen or androgen receptors (ER, AR), or inhibitors of steriodogenic enzymes. The FSTRA considers a variety of ...
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Effects of atrazine on endocrinology and physiology in juvenile barramundi, Lates calcarifer (Bloch)
Exposure to certain environmental contaminants such as agricultural pesticides can alter normal endocrine and reproductive parameters in wild fish populations. Recent studies have found widespread pesticide contamination across the rivers that discharge into the Great Barrier Reef lagoon. Potential impacts on native fish species exposed to known endocrine disrupting chemicals such as atrazine, ...
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Statistical analysis of histopathology endpoints
Histopathological assessments of fish from aquatic ecotoxicology studies are being performed with increasing frequency. Aquatic ecotoxicology studies performed for submission to regulatory agencies are usually conducted with multiple subjects (e.g., fish) in each of multiple vessels (replicates) within a water control and within each of several concentrations of a test substance. A number of ...
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Biochemical and histopathological alterations in kidney of rats chronically exposed to mild silver protein
Chronic administration to Wistar rats of Mild Silver Protein (MSP) to a dose of 222 mg Ag/kg/day in the drinking water for six months showed that the MSP produces argyria, with histopathological lesions in the kidney, the organ where silver accumulates. The histopathology of the kidney showed capillary damage, with alteration of the vascular wall, increased perivascular cellularity and area with ...
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Incidence of jaw lesions and activity and gene expression of hepatic P4501A enzymes in mink (Mustela vison) exposed to dietary 2,3,7,8‐tetrachlorodibenzo‐P‐dioxin, 2,3,7,8‐tetrachlorodibenzofuran, and 2,3,4,7,8‐pentachlorodibenzofuran
This study assessed the effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), 2,3,4,7,8‐pentachlorodibenzofuran (PeCDF), and 2,3,7,8 tetrachlorodibenzofuran (TCDF) on the incidence of jaw lesions and on hepatic cytochrome P4501A (CYP1A) endpoints in mink (Mustela vison). Adult female mink were assigned randomly to one of 13 dietary treatments (control and four increasing doses of TCDD, PeCDF, or ...
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Adult fathead minnow, Pimephales promelas, partial life‐cycle reproductive and gonadal histopathology study with bisphenol A
Bisphenol A (BPA) is an intermediate used to produce epoxy resins and polycarbonate plastics. Although BPA degrades rapidly in the environment with aquatic half‐lives from 0.5 to 6 d, it can be found in aquatic systems from widespread use. To evaluate potential effects from chronic exposure, fathead minnows were exposed for 164 d to nominal concentrations of 1, 16, 64, 160, and 640 µg/L BPA. ...
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Biomarkers of exposure and effect in a lacertid lizard (Podarcis bocagei seoane) exposed to chlorpyrifos
In Europe, reptiles have been recently included in environmental risk‐assessment processes for registration of plant‐protection products. However, data on toxicity effects of most compounds are lacking. Chlorpyrifos is the most commonly used organophosphorus insecticide worldwide. In the present study, the authors exposed a lacertid lizard, Podarcis bocagei, to sublethal concentrations of ...
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Sublethal propoxur toxicity to juvenile common carp (Cyprinus carpio L., 1758): Biochemical, hematological, histopathological, and genotoxicity effects
The sublethal toxicological and genotoxic potential of propoxur, a widely used carbamate insecticide against household pests, in veterinary medicine, and in public health, was evaluated on carp as a model species (Cyprinus carpio L., 1758) using the erythrocyte micronucleus test. Based on the 96‐h lethal concentration, 50% (LC50) data from the U.S. Environmental Protection Agency ECOTOX Database ...
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In ovo exposure to nonylphenol and bisphenol A resulted in dose‐independent feminization of male gonads in Japanese quail (Coturnix japonica) embryos
Sex reversal effects of nonylphenol and bisphenol A on the gonads in F1(AWE × WE) Japanese quail (Coturnix japonica) embryos were investigated using an in vivo screening model developed previously. The F1 (AWE × WE) Japanese quail are a useful avian model because sex differentiation is confirmed by the plumage color before hatching, ruled by a criss‐cross inheritance. The nonylphenol at 200, ...
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