Alfa Chemistry Medical Monitoring Services
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Manufactured by Alfa Chemistrybased in USA
In chemical concepts, dominant skeleton refers to the core structure of small molecules. In computational chemistry and medicinal chemistry, the skeleton also has the same meaning. The discovery of active compounds with novel skelecton is a great challenge for modern medicinal chemistry. It can not only improve the efficacy and drug-like properties of molecules, but also help pharmaceutical ...
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Manufactured by Alfa Chemistrybased in USA
One of the most important steps in the process of developing a medicine is determining its safety. Alfa Chemistry is dedicated to providing pre-clinical drug research services to support our clients' drug development, pre-clinical and clinical investigations, and assist them in deciding which drug candidates are most worthwhile to pursue in clinical trials. We emphasize pharmacology, ...
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Manufactured by Alfa Chemistrybased in USA
Alfa Chemistry has established a drug safety evaluation system that meets international standards. Our experimental studies strictly follow ICH, CFDA, FDA and OECD guidelines, providing our clients with high quality data and fast study cycles for preclinical safety evaluation of drugs. alfa chemistry helps our clients to shorten the experimental time and reduce the cost of new drug development ...
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Manufactured by Alfa Chemistrybased in USA
Ifosfamide has been effectively employed in the treatment of multiple cancers, including testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, non-Hodgkin lymphoma, Hodgkin lymphoma, epithelial ovarian cancer, cervical carcinoma and germ cell carcinoma of the ovary[1]. Among all these cancers, the Food and Drug Administration (FDA) has approved ifosfamide ...
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Manufactured by Alfa Chemistrybased in USA
Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can predict ADME parameters and pharmacokinetic properties by calculating ...
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Manufactured by Alfa Chemistrybased in USA
Alfa CDMO provides global CDMO services in the development and manufacturing of biopharmaceuticals, including mAbs, recombinant proteins, ADCs and bispecifics. We offer our partners contract services from DNA to finished drug product. Our technical expertise allows us to provide effective high-quality solutions for our partners biomanufacturing needs. In addition, Alfa CDMO delivers our ...
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Manufactured by Alfa Chemistrybased in USA
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds ...
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Manufactured by Alfa Chemistrybased in USA
Alfa CDMO's CRO offers custom services for research, optimization, and development phases of your project. ANTIBODY ENGINEERING CHEMICAL SYNTHESIS ANTIBODY DRUG CONJUGATION SCREENING ADC Assay and Mechanism Study Learn more: ...
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Manufactured by Alfa Chemistrybased in USA
Lead optimization is a complex and iterative process for identifying an improved drug lead with the goal of progressing to a preclinical candidate by altering the chemical structure of a confirmed hit. A diversity of properties such as target’s specificity, selectivity, pharmacodynamics, pharmacokinetics and toxicological properties are improved by modifying the chemical structures of compounds ...
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Manufactured by Alfa Chemistrybased in USA
Clinical Testing Laboratory: In order to provide an accurate and scientific basis for animal investigations, Alfa Chemistry's clinical testing laboratory performs clinical testing services such as animal biochemistry, hematology, coagulation, urinalysis, urine sediment microscopy, lymphocyte typing, in vitro hemolysis, and metabolite analysis. Our laboratory has highly automated tests and manual ...
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Manufactured by Alfa Chemistrybased in USA
Drug Discovery and Research: Alfa Chemistry aims to support efforts to generate novel drugs by serving as a one-stop platform for the variety of services and expertise needed for drug discovery and development. We will collaborate through a combination of integrated, multidisciplinary drug discovery expertise and capabilities across modality targets, platforms and therapeutic areas. We use a ...
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Manufactured by Alfa Chemistrybased in USA
Drug Research Service Platforms: Due to Alfa Chemistry's deeply ingrained research and development capabilities, we have been able to advance technologically in both research and development. In addition, we have been able to provide an integrated service platform for our customers' novel medication development ...
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Manufactured by Alfa Chemistrybased in USA
As one of the best medicinal chemistry team in the world, Alfa Chemistry offer comprehensive medicinal chemistry support to biotech and pharmaceutical companies engaged in drug discovery and research. We can provide service for all stages of medicinal chemistry activities including hit generation and target validation, hit-to-lead optimization, lead optimization and preclinical development. We ...
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Manufactured by Alfa Chemistrybased in USA
Nowadays, computational methods are routinely used to accelerate drug discovery process. In drug design and discovery, multiple computational chemistry approaches are employed to calculate and predict events, such as the drug binding to its target and the chemical properties for designing potential new drugs. At Alfa Chemistry, we apply the knowledge of computational chemistry to create various ...
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Manufactured by Alfa Chemistrybased in USA
The Alfa Chemistry platform integrates predictive methods with various computational techniques to accelerate drug discovery. Our iterative process is designed to accelerate evaluation and optimization of chemical matter in silico ahead of synthesis and assay. The most promising compounds emerging from each round of experimental project chemistry are then further optimized through additional ...
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Manufactured by Alfa Chemistrybased in USA
All combinatorial library methods include the following three main steps: library preparation, library components screening, and chemical structures of active compounds determination. The goal of chemical compound library design is to reduce the number of molecules as well as maintain the diversity of the library. Combinatorial library therefore has the potential of finding leads more rapidly ...
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Manufactured by Alfa Chemistrybased in USA
Clinical Pathology Laboratory: Pathology is a bridge discipline between basic and clinical medicine. The pathological examination can help diagnose diseases, understand the occurrence, development, and regression of diseases, especially identify the origin, nature, and scope of tumor tissues, determine the prognosis of tumors, and guide clinical treatment, especially targeted therapy. A team of ...
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Manufactured by Alfa Chemistrybased in USA
Chemical space docking is a novel approach for virtual screening which allows for handling multiple molecules occurring in combinatorial chemical spaces. Chemical space docking aims to predict actives based on their binding mode after a docking procedure with subsequent scoring of the complexes. Yet the source of the docked molecules is no longer an enumerated library but a combinatorial built-up ...
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