Medical Specialties Articles
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Self-amplifying RNA as a tool to tackle emerging flavivirus outbreaks: lessons learned from the COVID-19 pandemic
Background Outbreaks of multiple Flaviviruses have afflicted humankind for centuries due to their rapid spread predominantly by arthropod vectors. Global warming has caused epidemics to emerge in previously unaffected regions. The SARS-CoV-2 outbreak and subsequent race in vaccine development can provide strategies to the scientific community to avoid a flavivirus pandemic. The COVID-19 battle ...
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Catalase, a Common Antioxidant Enzyme
Catalase is an antioxidant enzyme commonly found in almost all living organisms, mainly in chloroplasts, mitochondria, endoplasmic reticulum of plants, liver and red blood cells of animals. It is the marker enzyme of the peroxisome, accounting for about 40% of the total peroxisomal enzymes. Catalase is a homotetramer composed of four polypeptide chains, each containing more than 500 amino acid ...
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Decreasing Benign Breast Ultrasound Biopsies: Prospective Use of AI Decision Support
After implementation of AI decision support, the benign biopsy rate decreased from 71.79% to 59.2% while the overall biopsy rate stayed constant. PPV3 increased from 28.2% to 40.8%. Objective To examine the affect of prospective AI decision support (Koios DS Breast) use on breast ultrasound biopsy performance metrics. Materials and Methods Non-identifiable HIPAA compliant data collected ...
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Applications of Diamine Oxidase
Diamine oxidase (DAO) is an intracellular enzyme that catalyzes diamine in mucosal or ciliated epithelial cells of the mammalian small intestine. It protects the intestinal mucosa by regulating intracellular ion homeostasis, influencing conduction pathways, and promoting cellular repair. Serum DAO is elevated in small intestinal mucosal barrier failure or in intestinal mucosal cell necrosis; ...
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Everything You Want to Know About Lipoprotein Lipase
Lipoprotein lipase (LPL) is a glycoprotein synthesized and secreted by parenchymal cells such as adipocytes, cardiomyocytes, skeletal muscle cells, mammary cells, and macrophages, with a molecular weight of 60ku and containing 3-8% carbohydrates. The physiological function of LPL is to catalyze the breakdown of TG in the core of CM and VLDL into fatty acids and monoglycerides for tissue oxidative ...
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Introduction to Lipogenesis, Lipid Anabolism and Catabolism
Sources of Fat Fat, also known as triglyceride, is made by condensing one molecule of glycerol and three fatty acids. The source of fatty acids in the body: one is the body's own synthesis, and the other is the food supply. Some unsaturated fatty acids cannot be synthesized by the body and depend on food supply, called essential fatty acids. There are mainly two kinds, one is the ω-3 series ...
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Pressure Ulcer - Case study
Patient History Patient presented with a history of hypertension, hyperlipidemia, peripheral arterial disease, obesity, arterial fibrillation, and transient ischemic attack. Patient had total knee replacement surgery and developed a complication due to improper off-loading, developing pressure ulcer on the right heel. Patient was treated with collagen products and wet to dry dressings prior to ...
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Dehisced Surgical Wound Post Ankle Fracture - Case study
Patient History Patient is a 35-year-old with obesity and venous insufficiency, status post-surgery for the repair of an ankle fracture. Surgical site dehisced and the patient was treated with Profore wraps, Unna boots, and standard wound care for two months. Primary Diagnosis Surgical dehiscence Treatment & Outcome Restrata was added to the treatment regimen and applied after wound ...
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Dehisced Surgical Wound Post Amputation - Case study
Patient History Patient is an 88-year-old female (post-BKA) who developed a large blister on the distal end of the stump within the first month post-op. It was treated with Kerlix and standard wound care at a LTCH. Three months later, the wound had a large area of eschar with purulent drainage. Patient taken to O/R for wound revision and primary closure with NPWT applied to the wound area. Wound ...
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Organic Acids Analysis
The organism undergoes thousands of biochemical reactions every moment to maintain our growth, development and energy metabolism. Under normal circumstances, these biochemical reactions proceed smoothly step by step through various cycles or certain steps. The process by which the body changes carbohydrates, amino acids, and fats from nutrients to absorbable substances and wastes is called the ...
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Features, Principles and Benefits of BioID
Features of BioID Biotin is a naturally occurring metabolic enzyme cofactor that is active only when covalently linked to the enzyme by the action of a specific protein-biotin ligase. Any biotinylated substrate can bind tightly to protein affin and streptavidin. Its main advantages include: 1. High sensitivity - The affinity between biotin and streptavidin (Kd=10-15 mol/L) is >1,000-fold ...
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Intraoperative Identification and Monitoring of the Somatic Nerves Critical to Potency Preservation during da Vinci Prostatectomy
Background Since Walsh and Donker first introduced the anatomic nerve-sparing technique for retropubic radical prostatectomy1 (RRP) in the treatment of clinically localized prostate cancer, the importance of minimizing damage to the neurovascular bundle (NVB) has been recognized as a critical element for the preservation of potency and urinary continence post-prostatectomy. Although originally ...
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High-resolution Map of Somatic Periprostatic Nerves
Objective To generate a high-resolution map of periprostatic somatic nerves. Periprostatic nerves are at risk of injury during radical prostatectomy; this study aimed to establish the location of somatic nerves with respect to the prostate and the neurovascular bundle. Materials and Methods Hemiprostates from patients in whom a wide local excision was performed were evaluated. Representative ...
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New Screening Solution Offers Hope in the Battle Against TB
In recent years, a number of ‘old’ diseases have re-emerged as significant threats to world health, driven by factors such as population migration and modern transportation. Of particular concern is the increase in the incidence of tuberculosis (TB) infection, a highly contagious disease spread through the air when infected people cough, sneeze or spit. According to statistics ...
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Results of Using a New Technology to Improve the Identification and Preservation of Nerve Tissue during Robotic-Assisted Laparoscopic Radical Prostatectomy
Introduction & Objectives Efforts to improve continence after robotic-assisted laparoscopic radical prostatectomy (RALRP) have focused on preserving periurethral and bladder neck tissue and techniques involving posterior reconstructions and anterior suspensions. Many patients, however, still have varying degrees of urinary incontinence. Literature has shown that nerves innervating the levator ...
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Cedars Sinai Affiliate Saves Thousands on Orthopedic Instruments, Implants and Disposables with OptioSurgical - Case Study
The Company Cedars Sinai Surgery Center of the Pacific This high-volume orthopedic facility is one of the most technologically advanced outpatient surgical facilities in Southern California. The center is owned by its physicians and focuses on sports medicine, joint replacement, and fracture fixation. The savings delivered by OptioSurgical resulted in a ROI in the first 90 ...
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Midwest ASC Management Company Realizes Over 50% Savings with OptioSurgical - Case Study
The Company Medical Consulting Group, LLC With 70 surgery centers across the country, MCG helps to provide surgery center management and development, and continuously looks for innovative ways to serve its surgery center partners. The savings delivered by OptioSurgical resulted in a ROI in the first 90 ...
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A breath screen for active tuberculosis at the point-of-care
Tuberculosis (TB) is on the rise, and traditional technologies are not up to the task of containing this fast-spreading disease. But a fast, robust, and low-cost optical system is enabling point-of-care testing Driven by various social factors, a number of “old” diseases have recently reemerged to significantly threaten world health. Of particular concern is the increase in ...
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Pelvic Autonomic Nerve Mapping Around the Prostate by Intraoperative Electrical Stimulation With Simultaneous Measurement of Intracavernous and Intraurethral Pressure
Purpose: In previous studies we noted that the neurovascular bundle was not identical to the bundle of the cavernous nerve fibers. In this study we sought to prove these anatomical findings electrophysiologically and map the autonomic nerve fibers by intraoperative simultaneous measurement of intracavernous pressure and intraurethral pressure. Materials and Methods: Between January 2004 and May ...
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Revolutionizing Education for Deaf and Hearing Students in One Classroom
When a teacher steps into a classroom knowing that a student is Deaf or hard-of-hearing, they must be prepared to manage communication in an effective manner. While navigating student disabilities can trigger uneasiness, recognizing that diversity will elevate the educational experience for all proves pertinent for classroom success. Whether a student is Deaf, hard-of-hearing, or fully ...
By Ava
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