Medical Specialties Articles
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Novel Biomarkers May Help Predict the Susceptibility of a Population to Rheumatoid Arthritis
Genetics (i.e., mutations) are considered to be the main factor predisposing to the etiology of rheumatoid arthritis (RA), but they account for only a few changes in RA disease risk, and in contrast to genetics, the environment may have an important impact on epigenetic properties associated with disease etiology. Recently, in a study published in the journal Scientific Reports entitled ...
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Research Progress of Targeted Protein Degradation Technology
The mode of action of currently developed drugs is mostly to achieve the purpose of disease treatment by inhibiting or enhancing the activity of target proteins. However, these drugs have to bind to the active site of target proteins to work. Among the known drug target proteins, only about 20% of the target proteins contain bindable active site, and 80% of the target proteins are non-druggable ...
By Profacgen
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Science: Blocking fibrin holds promise for the treatment of periodontal disease
In a new study, researchers from the National Institute of Dental Craniofacial Research (NIDCR) have found that blocking the function of a coagulation protein prevents bone loss caused by periodontal (gingival) disease in mice. According to animal and human data, they found that the accumulation of this clotting protein called fibrin triggers an excessive immune response that damages the gingiva ...
By Matexcel
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Special Genes May Affect the Level of Lipopolysaccharide in the Body’s Blood
Transfer of lipopolysaccharide from gram-negative bacteria into the systemic circulation of the body leads to the development of endotoxemia, which is detected in cardiometabolic diseases such as cardiovascular disease and obesity in addition to acute infections. Lipopolysaccharide is a virulence factor produced by bacteria, which often triggers systemic inflammation through the body's ...
By CD BioGlyco.
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Detailed Introduction to Steroids Analysis
Steroid hormone is a class of compounds that contain cyclopentane polyhydrophenanthrene structure formed by cholesterol and catalyzed by cytochrome P450 enzymes. Steroid hormones mainly include adrenocorticotropic hormones secreted by the adrenal cortex and sex hormones secreted by the gonads, which are mainly divided into four categories: progesterone, corticosteroid, estrogen and androgen. ...
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IMOGEN - Contrast-Free Magnetic Resonance Imaging for Breast Disease - Case Study
This is an observational cohort study looking at women, 30 years of age or older with a concern or at risk of suspected breast disease or breast cancer. The proposed study aims to examine the diagnostic performance of non-contrast MRI in breast disease by applying quantitative multiparametric MRI ...
By Perspectum
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West Hertfordshire IBD technology study - Case Study
Observational study with retrospective and prospective data collection, for total of 24 months. This is an IBD technology study investigating quantitative metrics for endoscopy, histology and radiology for improved diagnosis and assessment of ...
By Perspectum
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UK Imaging Diabetes Study Seeing Diabetes Clearly - Case Study
Prospective observational cohort study with clinical outcomes data collection. Recruiting adult patients with type 2 diabetes (T2DM) and diabetic retinopathy (DR), who lack history of cardiovascular ...
By Perspectum
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Probiotics Have Many Benefits for the Human Body
Probiotics are active microorganisms that are beneficial to the human body. They promote nutrient absorption and maintain the health of the intestinal tract by regulating the balance of the intestinal flora. The human intestinal flora contains a large number of microorganisms, as many as hundreds of species. In addition to probiotics, there are other microorganisms, such as viruses, fungi, ...
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Learn the Properties and Applications of Chymotrypsin
Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals. ...
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Broad Application Areas of Cellulase Release Strong Market Demand
Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose into glucose, thereby providing ...
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New Study Findings about Glycoprotein PTGDS
Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalcitonin superfamily that plays a dual role in prostaglandin metabolism and lipid transport. PTGDS is involved in various cellular processes including solid tumorigenesis, but its role in tumorigenesis is paradoxical, and the significance of PTGDS in hematologic malignancies is not clear. The aim of this new study was to ...
By CD BioGlyco.
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The Mode of Action of Basic Proteins Involved in Cancer and Alzheimer's Disease Found
These proteins belonging to the HAT family are essential for life because they transport amino acids to the cell membrane. Although members of the family are nearly identical, they selectively transport certain amino acids. This specificity determines their involvement in specific functions, such as cell growth or neuronal function, and consequently in related diseases, such as cancer or ...
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Everything You Want to Know About Alkaline Protease
Alkaline protease is a serine proteolytic enzyme in endopeptidases, which can hydrolyze protein peptide bonds under alkaline conditions, and its optimal pH range is 9-11. It is mainly used in the enzyme detergent industry, and it is also widely used in industries such as tanning, silk, feed, medicine, food, and environmental protection. This enzyme was first found in the pancreas of pigs. At ...
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CD Genomics Perspective: Introduction to Virus Identification Using RNA Sequencing
RNA sequencing (RNA-Seq) is a high-throughput RNA profiling technique that uses next-generation sequencing (NGS) platforms, and offers accurate abundance estimations over a wide dynamic range. Both high and low expression levels in individual viral RNA sequencing experiments can be determined using a wide dynamic range, which greatly improves analysis efficiency. As a result, RNA-seq has played ...
By CD Genomics
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Structural Characteristics and Functions of Glycoproteins, Proteoglycans and Glycolipids
Sugar is an important nutrient for the human body, and its primary physiological function is to provide energy and carbon sources for life activities. In addition, sugar also participates in the composition of glycoproteins and glycolipids, and regulates cell information transmission. Monosaccharides are polymerized by glycosidic bonds to form oligosaccharides or polysaccharides, also called ...
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Researchers highlight the impact of COVID 19 pandemic on patients with cancer
New collaborative research from Queen’s University Belfast, the University of Split, Croatia and King’s College London has shown that the response to the outbreak of the coronavirus disease 2019 (COVID-19) is significantly affecting the treatment and care of patients with cancer. The research, recently published in the European Journal of Cancer, highlights how the repurposing of ...
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Science: Knockout of this epigenetic gene gives CAR-T cells the ability to continuously attack cancer cells
Simply put, CAR-T is to transform the patient's immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells. In 2017, CAR-T therapy was first approved by the FDA for the treatment of blood cancers such as leukemia and lymphoma. ...
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Protein Acetylation and Ubiquitination Interactions Control MCL1 Protein Stability
The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the BCL2 family that supports survival and is frequently amplified or upregulated in human cancers. MCL1 is highly unstable and its stability is regulated by phosphorylation and ubiquitination. Here, the authors suggest that acetylation is another key post-translational modification that regulates MCL1 protein instability. The ...
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Multifunctional Black Bioactive Ceramic Material Developed Recently
Bioceramic materials have a long history of being used to repair human hard tissues, from biologically inert materials (such as alumina and zirconia, etc.) to biological materials that are both biologically active and degradable (such as phosphate and silicate bioceramics, silicon Based bio-glass, etc.), its physiological function is no longer a simple tissue filling substitute, but a tissue ...
By Matexcel
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