Bone Cancer Articles
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What are Radionuclide Drug Conjugates (RDCs)?
Coupling drugs combine the precise targeting and potent killing properties, has become a widely recognized form of medication in recent years. Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. According to the application of RDCs, they can be divided into two main categories: diagnostic RDCs ...
By BOC Sciences
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Mechanism of Action of Paclitaxel
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and complex chemical structure, extensive and significant biological activity, unique mechanism of action, and scarce natural resources have gained immense favor among ...
By BOC Sciences
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Biological Tissue Spectroscopy for Better Health
Executive Summary A fully scalable optical tissue spectroscopy solution has been developed for a wide range of applications to improve healthcare diagnostics and outcomes. As a result, health practitioners can now implement quantitative tissue spectroscopy can help them improve health outcomes in their field of work. The Zenascope™ Quantitative Optical Spectrometer uses standard ...
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Navigating Cancer’s, Dr. Amila Patel, Provides Insight on Racial Disparities in Recent Cancer Treatment Study
Navigating Cancer, Chief Clinical & Strategy Officer, Dr. Amila Patel, PharmD, BCOP, recently presented data on key findings from a recent abstract with Duke Health revealing racial disparities among head and neck cancer populations at the 2022 American Society of Clinical Oncology conference. Our research, along with our partners at Duke Health, found there were significant health care ...
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Inflammation in Periodontal Disease a Red Flag for Cancer
By not taking care of your teeth there is more on the line than tooth decay and periodontal disease – although that’s bad enough. Practicing good oral hygiene may be lifesaving according to a number of research studies.Studies show a connection between Gum disease and a 63% HIgher Pancreatic Cancer in Men The link between several systemic illnesses including diabetes, heart disease, ...
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Introducing Navigating Cancer’s Medical Advisory Board Ahead of ASCO Presentations Illustrating Equitable Cancer Care Innovation
Navigating Cancer is filling an important role in the healthcare community during a time that has placed tremendous pressure on healthcare providers to better support a growing and diverse patient population, outside-of-the-clinic. Digital health tools and remote symptom monitoring enable more efficient care delivery and improve patient outcomes – while providing actionable insights based ...
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How does your Vaginal Microbiome Affect your Cancer Risk?
When you hear about the vaginal microbiome (VMB), your first thought may be the role it plays in stuff like yeast infections or bacterial vaginosis (BV). But with improved research, we’re uncovering more of the VMB’s long-term effects, like its role in a healthy pregnancy and delivery. The complex community of organisms living in your vagina even plays a part in your risk of ...
By Juno Bio
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LAG-3 antibody drug R&D boom
On March 19, Bristol-Myers Squibb (BMS) announced that its dual immunotherapy combination Opdualag had received accelerated marketing approval from the FDA. Opdualag therapy is a fixed-dose combination of Relatlimab (anti-LAG3) and Nivolumab (anti-PD1) for the treatment of adult and pediatric patients 12 years of age and older with unresectable or metastatic melanoma, making LAG-3 the third ...
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EMI-137: image guided surgery of penile and head and neck cancer (NL) - Case study
Title: Intra-operative evaluation of a novel fluorescent c-Met tracer in penile and tongue cancer Objective: Evaluation of the feasibility of intraoperative visualization of penile and tongue tumours using the fluorescent tracer EMI-137. Status: Study Completed Results: See pubished material here and ...
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Gamma delta T cells in tumor immunotherapy
Immunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those ...
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CD Genomics Perspective: Introduction to Virus Identification Using RNA Sequencing
RNA sequencing (RNA-Seq) is a high-throughput RNA profiling technique that uses next-generation sequencing (NGS) platforms, and offers accurate abundance estimations over a wide dynamic range. Both high and low expression levels in individual viral RNA sequencing experiments can be determined using a wide dynamic range, which greatly improves analysis efficiency. As a result, RNA-seq has played ...
By CD Genomics
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Multifunctional Black Bioactive Ceramic Material Developed Recently
Bioceramic materials have a long history of being used to repair human hard tissues, from biologically inert materials (such as alumina and zirconia, etc.) to biological materials that are both biologically active and degradable (such as phosphate and silicate bioceramics, silicon Based bio-glass, etc.), its physiological function is no longer a simple tissue filling substitute, but a tissue ...
By Matexcel
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Science: A protein-protein interaction map of breast cancer constructed
Advances in DNA sequencing technology have made it possible to extensively analyze the breast tumor genome and construct a catalog of gene mutations that may initiate or drive tumor progression. In addition to the well-known common mutations in oncogenes (such as TP53 and PIK3CA), breast cancer also contains a variety of rare mutations that have a low incidence in the patient population. Despite ...
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Global ADC Drug Overview
In recent years, antibody-drug conjugates (ADCs) have been widely sought after due to their excellent clinical performance and market returns. ADC drugs are composed of three parts: antibody, effector molecule (Payload, usually cytotoxic agent) and linker. Compared with traditional drugs, ADC drugs have obvious advantages in improving targeting and reducing side effects. 1. Global ADC listing ...
By BOC Sciences
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Pioneering VeraForm in Head and Neck Cancer Treatment: Sarcomatoid Carcinoma Tumor Bed Marking
Head and neck cancer surgery presents a number of unique challenges, not only for the surgeon but for the radiation oncologist who will subsequently treat those patients. Great care with an emphasis on precision must be taken to ensure that critical structures and tissues avoid collateral damage when possible. However, given the surgical site often lies in soft tissue, exact identification of the ...
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Myths vs Facts: HPV and Cervical Cancer
Cervical cancer is the second most common cancer affecting and causing deaths among women in India. Cervical cancer is caused by the Human Papilloma Virus or HPV. The lower part of the uterus known as Cervix is affected due to HPV infection. This cancer develops very slowly and most of the times is asymptomatic during the development stage. HPV infection is a sexually transmitted infection (STI) ...
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Cytotoxicity of activated natural killer cells against pediatric solid tumors
Abstract Purpose: To develop new therapies for children with solid tumors, we tested the cytotoxicity of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought to identify the most sensitive tumor subtypes, clarify the molecular interactions regulating cytotoxicity, and determine NK antitumor potential in vivo. Experimental design: We tested in vitro ...
By Nkarta, Inc.
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Bone cancer risk in mice exposed to 224Ra: protraction effects from promotion
This paper analyzes data for the osteosarcoma incidence in life-time experiments of 224Ra injected mice with respect to the importance of initiating and promoting action of ionizing high LET-radiation. This was done with the biologically motivated two step clonal expansion (TSCE) model of tumor induction. Experimentally derived osteosarcoma incidence in 1,194 mice following exposure to 224Ra with ...
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