Cancer Research Articles
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A Closer Look at Reporter Lentiviral Particles: Tool for Biomedical Research
Introduction For years, scientists have leveraged the brilliant potentialities of genetic science to explore how cells function and interact in living organisms. Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the ...
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Unveiling the Role of CDH1 Protein in Cancer and Future Research Directions
Introduction CDH1, also known as E-cadherin, is a crucial protein involved in cell adhesion and plays a significant role in various biological processes. In recent years, researchers have focused on understanding the functions of CDH1 and its implications in cancer development. This blog post aims to shed light on what CDH1 protein does, its role in cancer, and the future research directions in ...
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Shining a Light on Drug Delivery: The Rise of Fluorescent Liposomes
Imagine tiny spheres, smaller than a red blood cell, glowing as they navigate the labyrinthine corridors of the human body. These aren't fireflies, they're fluorescent liposomes, a cutting-edge tool in the world of drug delivery and biomedical research. What are liposomes? Liposomes are microscopic bubbles made from phospholipids, the same fatty molecules that make up cell membranes. These ...
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CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology
CD Genomics, a well-established leader in transcriptome solutions, is pleased to announce the introduction of Ribosome Profiling technology. This innovative technique promises to provide valuable insights into gene expression, protein synthesis, and regulation, offering potential advancements in the field of RNA translation research. Ribo-seq is a cutting-edge high-resolution sequencing ...
By CD Genomics
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Clonality Analysis Service: A Paradigm Shift in Disease Diagnosis and Treatment
Understanding Clonality Analysis Clonality refers to the origin of a cell population from a single 'parent' or progenitor cell through asexual reproduction or division. This concept is vital in cancer studies as it helps track the development of tumor cells from a single mutated cell. Clonality analysis is thus essential in understanding the evolution and the spread of cancerous cells in a ...
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Utilizing Zebrafish Genome Editing Services: Shaping the Future of Genomic Research
Within the rapidly advancing realm of biotechnology, zebrafish genome editing services are carving a niche, heralding a new epoch in genomics and cellular research. This development is driving innovative research approaches, empowering researchers to create effective models to comprehend complex genetic interactions and responses quickly and efficiently. Zebrafish, also known as Danio rerio, ...
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Inflammation, Immunity and Cancer
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune ...
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Understanding Drug-Disease Relationship Analysis: A Key to Drug Discovery
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
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Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
By CD Genomics
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Establishment of a Stable Organoid Culture System: Customization and Standardization
Prefix Organoids are miniature organs created in vitro from adult stem cells (ASCs) or pluripotent stem cells (PSCs). They form three-dimensional (3D) tissue-like structures through the self-organization, self-renewal, and differentiation capabilities of stem cells. Compared to traditional two-dimensional (2D) cell cultures or spheroids, organoids closely resemble living organs in terms of ...
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How to Design a Good ADC Drug
In the past ten years, the number of antibody drug conjugates (ADCs) entering clinical trials has steadily increased. Currently, 9 ADCs have been approved, of which 5 are used for hematoma and 4 for solid tumor treatment. After more than 20 years of development, ADC biopharmaceuticals are becoming the main force in the treatment of cancer. Currently, one of the most important challenges when ...
By BOC Sciences
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Optimization of Three Elements of ADC Drugs
Structurally, an ADC consists of monoclonal antibodies (Antibody) that target specific antigens on tumor surfaces, cytotoxic drugs (drugs) that kill tumor cells, and linkers (Conjugate/ linkers) that conjugate cytotoxic drugs to antibodies. The link between the antibody and linker is controlled by the coupling method, which determines the DAR value of the drug and affects the stability and PK ...
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Detecting Fusion Transcripts by RNA Sequencing in Screening Tumors
What is fusion gene? What is Chimeric RNAs? A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors. For example, in chronic granulocytic leukemia, ...
By CD Genomics
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CD Genomics Supports Immune and Cancer Research with TCR-Seq Service
CD Genomics is a world-leading genomics services company that continues to innovate in high throughput sequencing services for the genomics industry, as well as genotyping, bioinformatics, microarrays, and more. The company has recently launched TCR-seq, a powerful service that enables rapid and efficient analysis of T-cell receptor (TCR) diversity and clonality, providing critical support for ...
By CD Genomics
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TPD Show Potential For The Treatment of Alzheimer's Disease
Targeted protein degradation (TPD) is a promising strategy in the field of drug discovery. In recent years, targeted protein degradation (TPD) technology has developed rapidly, especially proteolysis targeting chimera (PROTAC), which is the most representative technology of TPD strategy. TPD drugs are one of the hot spots of new drug development in recent years, especially in the field of ...
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Navigating the Bioinformatics Workflow for Whole Exome Sequencing: A Step-by-Step Guide
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics research. At the moment, Illumina, Ion Torrent/Life Technologies, 454/Roche, Pacific Bioscience, Nanopore, and GenapSys are all NGS platforms that can be used. They can produce reads of 100–10,000 bp in length, enabling sufficient coverage of the genome at a ...
By CD Genomics
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ABS-INT-001 Internalizing Ab-ADC for Cancer Therapeutics - Case Study
Background Growth factor X is a well-characterized target that is involved in multiple proliferation-related signal transduction pathways Growth factor X expressed in multiple cancer types and therefore is an ideal target cancer therapies ...
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Immune Strategies for Cancer Treatment
In the search for innovative and effective ways to target cancer, we are faced with more than just a challenging problem; we are faced with our own cells as opponents. Cancer cells evolve to achieve an optimum of physical fitness, giving them an array of abilities that no cell should possess in a healthy organism. One way to find novel therapies against cancer therefore could imply finding a ...
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Advancing patient care for Japan`s most common cancer - Case Study
Challenge Calculating the appropriate sample size for a first of its kind stage-II colon cancer trial As Chairman of the Department of Biostatistics, Professor Satoshi Teramukai leads a variety of investigator-initiated clinical trials at the Kyoto Prefectural University of Medicine. With over 35 years experience, hundreds of published papers and thousands of citations, Professor Satoshi ...
By Statsol
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Sutter Health: HDR Surface Brachytherapy for Penile Cancer - Case Study
This case is an example of how Adaptiiv’s software can be used to create customized HDR applicators for skin brachytherapy, particularly for challenging sites with extreme curvature. A custom 3D printed applicator can be used as a solution to overcome poor setup reproducibility and inconsistent contact between skin and ...
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