Coronary Care Articles
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Unraveling the IL-17 Family and its Receptor Complex: Key Players in Immune Responses
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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Cellular and molecular differences between HFpEF and HFrEF
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
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What is heart failure with preserved ejection fraction (HFpEF)?
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
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The latest developments of Medis QFR
December 2022 edition Given the regular posts of peer-reviewed scientific publications on the Medis QFR®, it is clear that this angio-based solution for coronary physiology is extensively used in clinical research and practice. We would like to share these publications with you so that you remain up to date about the research that is ongoing worldwide with this innovative solution, ...
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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LAD and 1st diagonal branch bifurcation with additional disease in distal in LAD - Case Study
Moderate diffuse coronary disease LAD and side branches. Medina 1,1,1 lesion LAD and 1st diagonal branch. Distal LAD lesion planned to be treated after Tryton and proximal main branch DES deployment. Radial approach. Predilatation of side branch with 2.5/15mm non compliant balloon. Tryton 3.0/3.5mm deployed followed by POT of side branch ostium with 3.5mm NC ...
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EluNIR DES in a Challenging Case - Case Study
Background: This paper describes a challenging case of implantation of the EluNIR™ Ridaforolimus eluting elastomeric stent (Medinol Ltd.). This complex case involved a patient with a flow-limiting lesion in a native coronary artery post bypass surgery. The new EluNIR stent system includes a stent with a low metal footprint that comprises struts of variable width: ultra-narrow struts ...
By Medinol
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EluNIR First-in-Patient Implantation- Case Study
Background This paper outlines the first in-patient implantation of the EluNIR™ ridaforolimus eluting elastomeric stent (Medinol Ltd.). This complex case involved a patient with a flow-limiting lesion in a native coronary artery post bypass surgery. The new EluNIR stent system includes a stent with a low metal footprint which comprises struts of variable width: ultra-narrow struts having ...
By Medinol
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A Contemporary Review of ST-Elevation Myocardial Infarction: Pathophysiology, treatment options and hot topics
Pathophysiology, treatment options and hot topics Improvements In Stemi Treatment The immediate and long-term prognosis of patients experiencing an ST segment elevation myocardial infarction (STEMI) has changed dramatically since the introduction of coronary reperfusion therapies during primary percutaneous coronary intervention (pPCI). The evolution of these therapies accelerated with the ...
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Physiology and Pathology of Coronary Microcirculation
The heart is a unique organ in many respects since its activity is mandatory to sustain life. The heart’s circulatory system and coronary flow regulation are highly adapted to the vital role of the heart in sustaining life and to everyday physiological challenges. Understanding coronary physiology is key for treating patients with ischemic heart disease in general, and ...
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Exercising Coronary Artery Disease patient - Case study
A cyclo-ergometer exercise test was performed on this 57-year old male patient. He is a smoker with a family background of CAD. He is suffering from left bundle branch block making ST-segment analysis impossible. The patient has achieved 78 % of max. heart rate at 120 watts. Moderate paleness and dyspnoea have been observed at the end of the 120 watts step. However, after a normal initial ...
By PhysioFlow
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Autotransfusion device maker ships units to Ukraine
The developer of an autotransfusion device for collecting and cleaning a patient’s lost blood is sending hundreds of units to Ukraine as casualties climb from the Russian invasion. Baltimore-based Sisu Global Health has already sent 1,005 of its Hemafuse devices to hospitals in Kyiv and is planning a third shipment of 500 more any day now, co-founder and President Gillian Henker said. ...
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Atrial Flutter - Typical Atrial Flutter (AFL) - Case Study
Typical Atrial Flutter (AFL) is the most common type of atrial flutter and is a macro-reentrant right atrial tachycardia that uses the cavo-tricuspid isthmus as an essential part of a counter-clockwise circuit. The tendon of Todaro, the crista terminalis, the inferior vena cava, the tricuspid valve annulus, and the coronary sinus os provide anatomical landmarks of the circuit. Typical AFL can be ...
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Dental Problems Linked To Heart Disease and Diabetes
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. Every day new research is making the link stronger. Periodontal infection is the advanced stages of gum disease that causes bone loss. The bone loss is irreversible. Gingivitis is the early stage of gum disease and with early ...
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Chocolate PTCA Balloon Catheter for pre-dilatation of an occluded right coronary artery - Case Study
Incomplete stent expansion and malapposed stent struts are a predictor of subacute and late stent thrombosis. Appropriate lesion preparation prior to stent implantation is necessary to assure complete stent expansion and stent strut apposition. This is of particular importance in challenging lesions, in particular those with calcific plaque. The goal of the pre-dilatation is to obtain optimal ...
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Introduction and Detection Methods for Phytochemicals
What Are Phytochemicals? Phytochemicals are natural compounds that have only been discovered so far and are natural food pigments. The human body is unable to produce them and must obtain them from food. Soy isoflavones in soybeans, lycopene in tomatoes, catechins in green tea, carotenoids in carrots, zeaxanthin, polyphenols, etc., are all phytochemicals. Classification and Functions of Common ...
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ABILITY Diabetes Global enrolls thousandth patient: A Cardinal Milestone Achieved
ABILITY Diabetes Global (Randomized Comparison of Abluminus DES+ Sirolimus-Eluting Stents versus Everolimus-Eluting Stents in Coronary Artery Disease Patients with Diabetes Mellitus Global) started off with the index patient enrolment on 11th June 2020 in Italy (at the peak of the 1st wave of COVID-19 pandemic) by P.I. Prof. Antonio Colombo and the pace of enrolment since then has been steady and ...
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Effect of endothelium mimicking self-assembled nanomatrices on cell adhesion and spreading of human endothelial cells and smooth muscle cells
Abstract The goal of this study is to develop unique native endothelium mimicking nanomatrices and evaluate their effects on adhesion and spreading of human umbilical vein endothelial cells (HUVECs) and aortic smooth muscle cells (AoSMCs). These nanomatrices were developed by self-assembly of peptide amphiphiles (PAs) through a solvent evaporation technique. Three PAs, one containing the ...
By Endomimetics
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Chronic Total Occlusion – Left Anterior Descending Proximal to Mid Lesion - Case study
Overview Dr. Craig Rosen used the Teleport® Microcatheter and several Sapphire® II PRO and Sapphire® NC Plus PTCA Balloons to perform a proximal to mid left anterior descending coronary artery (LAD) revascularization of a chronic total occlusion using stents. Patient History A 60-year-old Caucasian male patient with a BMI of 29, so overweight but not obese, presented ...
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