Heart Diseases Articles
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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How to Build a Complete First Aid Kit
Comprehensive Guide to Building and Maintaining First Aid Kits for Home and Emergency Preparedness Introduction Life is full of challenges, from unexpected injuries to sudden emergencies. Some we can prepare for with caution, while others catch us off guard. In these critical times, a first aid kit becomes our frontline defense against unforeseen crises. But are you really ready? Yes, those ...
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Overview of Diabetes: Prevalence Assessment, Treatment And Prevention
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. In China, there are more than 114 million adults with diabetes, accounting for about a quarter of the world's diabetes patients. With the change of living and eating habits, diabetes has become the third major factor affecting human health after ...
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Ion Channel Screening & Profiling: Unlocking a New Dimension in Drug Discovery
In the realm of drug discovery, researchers are constantly striving to unlock new possibilities for the treatment of diseases. One crucial aspect of this endeavor is the understanding and exploration of ion channels - integral membrane proteins that regulate the flow of ions across cell membranes. These channels play a fundamental role in numerous physiological processes and are essential targets ...
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Unravelling the Hypertension Puzzle
In this busy and crowded world, no one has the time or energy to look after themselves; our lack of effort and diminished sense of responsibility towards our health has led to stress, tension, and various health issues becoming an inseparable part of our lifestyle. One of the most popularly spread health issues is hypertension. According to estimates by The World Health ...
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Enzymes for Disease Diagnosis: An Overview
Enzymes are protein molecules that catalyze chemical reactions in living organisms. They are involved in many metabolic processes and play a critical role in maintaining the health of the body. In recent years, enzymes have been widely used in disease diagnosis, providing a quick and accurate way to detect and monitor diseases. Enzymes for disease diagnosis can be divided into two categories: ...
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How Health Apps and Devices are Changing the Way We Manage our Health
There has been a recent shift in how we approach health and well-being. We now have more control over our health and fitness thanks in large part to Remote Patient Monitoring (RPM) apps and equipment. Health applications and technologies are transforming how we manage our health, from tracking our everyday activities to monitoring our vitals and chronic illnesses. Health apps and devices are ...
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Predicting cardiotoxicity with engineered 3D human cardiac tissue models
Cardiovascular safety liabilities caused 52.3 % of 44 marketed data from 1980 to 2011, and cardiovascular disease remains the leading cause of death globally, yet only 8.7% of cardiovascular drugs successfully pass clinical trials. These statistics demonstrate the need to address a patient’s specific genetic make-up and phenotype by adopting a personalized treatment methodology for ...
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Diagnosing heart failure with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine, overtaking heart failure with reduced ejection fraction (HFrEF) and becoming the most common form of heart failure, with a prevalence that is increasing by 1% annually.[1] Despite this, there remains no gold standard in diagnosing HFpEF. Diagnosing ...
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What is heart failure with preserved ejection fraction (HFpEF)?
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
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Targeted Region Sequencing in Human Disease Studies and Clinical Care
Introduction to target region sequencing Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers to obtain whole genome or targeted regions of samples. Targeted region sequencing is preferred by ...
By CD Genomics
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When IT and OT converge: Paving the way for smarter healthcare
Good decision-making relies on good information. That’s why data collection is so important to businesses of all types. In healthcare, it can literally be a life-and-death concern. Currently, two data-related trends are delivering new levels of optimization in hospitals with the potential to vastly improve operations and safety: The convergence of information technology (IT) systems ...
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How Sleep Deprivation Can Lead to Weight Gain
Sleep is an important factor to help maintain health and well-being. It’s recommended that an adult should get at least 7 hours of sleep a night. Getting a good night’s sleep has many benefits such as better memory, reduced stress levels and lowers the risk of heart disease. On the flip side, not getting enough sleep regularly can have serious repercussions such as a weaker immune ...
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The Use of High-Frequency Jet Ventilation in the Management of a Pre-term Infant with Pulmonary Stenosis and Respiratory Distress Syndrome. – A Case Report
The combination of congenital heart disease (CHD) and respiratory distress syndrome (RDS) can present a difficult scenario to manage with conventional mechanical ventilation (CMV). Our patient presented with poor right ventricular (RV) function, and refractory respiratory failure on CMV. High-frequency jet ventilation (HFJV) was used in order to improve ventilation at a similar or lower mean ...
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Physiology and Pathology of Coronary Microcirculation
The heart is a unique organ in many respects since its activity is mandatory to sustain life. The heart’s circulatory system and coronary flow regulation are highly adapted to the vital role of the heart in sustaining life and to everyday physiological challenges. Understanding coronary physiology is key for treating patients with ischemic heart disease in general, and ...
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Bartonella quintana: Putting the re-emerging in emerging infection
Introduction Trench fever was a defining feature of World War I. Notables like A.A. Milne, author of Winnie-the-Pooh, and fantasy writer JRR Tolkien were treated for trench fever. But surely trench fever did not just appear in the European trenches of World War I and then disappear after. What’s the rest of the story? Before World War I, Way Before While infections caused ...
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Walk with Tab for Heart Health
Tab Lassiter – an employee of global vaccines leader CSL Seqirus – is about to receive a second transplant in an ongoing battle with a heart condition. He shares his story to explain why it’s critical to spread the word about heart health. Tab Lassiter once spent eight months resting anxiously in a hospital bed with cardiomyopathy, a condition that can lead to heart ...
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Dental Problems Linked To Heart Disease and Diabetes
Dental Problems Linked To Heart Disease and Diabetes Over the last ten years there has been a growing body of evidence linking periodontal disease and systemic diseases. Every day new research is making the link stronger. Periodontal infection is the advanced stages of gum disease that causes bone loss. The bone loss is irreversible. Gingivitis is the early stage of gum disease and with early ...
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Inflammation in Periodontal Disease a Red Flag for Cancer
By not taking care of your teeth there is more on the line than tooth decay and periodontal disease – although that’s bad enough. Practicing good oral hygiene may be lifesaving according to a number of research studies.Studies show a connection between Gum disease and a 63% HIgher Pancreatic Cancer in Men The link between several systemic illnesses including diabetes, heart disease, ...
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Link Between Periodontal Disease and Oral Cancer
There is a strong relationship between periodontal disease and oral cancer. In patients with tongue cancer, the periodontal disease preceded the tongue cancer. Although periodontal disease and oral cancers are both located in the mouth, until recently, there was never thought to be a connection between the two. New evidence is coming to light to show that those with periodontal disease increase ...
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