Kidney Disease Articles
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Classes and Applications of Cell-Penetrating Peptides
Classes of Cell-Penetrating Peptides There are many types of cell-penetrating peptides (CPPs), and their classification is based on physicochemical properties, sources, intake mechanisms, and biomedical applications. There is no unified conclusion yet. According to their physical and chemical properties, CPPs can be divided into three types: cationic, amphiphilic and hydrophobic, among which ...
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Overview of Diabetes: Prevalence Assessment, Treatment And Prevention
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. In China, there are more than 114 million adults with diabetes, accounting for about a quarter of the world's diabetes patients. With the change of living and eating habits, diabetes has become the third major factor affecting human health after ...
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Will Metformin Be Replaced By SGLT-2 Inhibitors
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple ...
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Bladder management practice for spinal cord injury patients
The spinal cord is to relay messages between the brain and the rest of the boy. When spinal cord injury happens the body may lose some essential functions if the nerves can’t communicate with the brain. Inadequate bladder management of spinal cord injury (SCI) results in medical complications, psychological stress and even mortality. Frequent leakage of urine causes soiling of clothes ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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Cellular and molecular differences between HFpEF and HFrEF
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
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What is heart failure with preserved ejection fraction (HFpEF)?
Overview What is HFpEF? Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). Most patients with HFpEF also display normal LV volumes and an abnormal diastolic filling pattern (i.e, diastolic ...
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Common Gamma Chain Cytokines in Cancer Immunotherapy
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
By Quartzy Inc.
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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Diabetic Foot Ulcer - Case Study
Healing rate: 25.3 mm2/day. Healing time: 33 days. Wound size: 38 × 22 × 8 mm. Age of wound when treatment started: > 1 year. Subject: 52/male. Insulin dependent diabetic, peripheral neuropathy, hypertension, renal failure on hemodialysis; history of chronic foot ...
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Association between Diabetes Mellitus and chronic kidney disease with Muscle loss and weight loss
Muscle loss / muscle wasting is the condition in which, proteolytic systems for protein degradation are activated, while protein synthesis decreases, thereby resulting in muscle fiber shrinkage. This condition may be due age or might be due some chronic conditions like Diabetes mellitus (DM) or chronic kidney disease (CKD). Extreme muscle wasting often results in weight loss. Such a condition is ...
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Applications of Cell-penetrating Peptides
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides ...
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Inflammation in Periodontal Disease a Red Flag for Cancer
By not taking care of your teeth there is more on the line than tooth decay and periodontal disease – although that’s bad enough. Practicing good oral hygiene may be lifesaving according to a number of research studies.Studies show a connection between Gum disease and a 63% HIgher Pancreatic Cancer in Men The link between several systemic illnesses including diabetes, heart disease, ...
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Dental Problems Often Cause Bad Breath
The Direct Link between Bacterial Plaque, Bad Breath, and Dental problems Bad breath or halitosis, dental decay, periodontal disease, and gingivitis are all caused by the anaerobic bacteria that live in the mouth. Anaerobic means living in the absence of air. These types of bacteria are mostly pathological. Bad breath is the odor produced by bacteria living off food particles, each other and ...
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Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection
Background: Synthetic expanded polytetrafluorethylene (ePTFE) grafts are routinely used for vascular repair and reconstruction but prone to sustained bacterial infections. Investigational bioengineered human acellular vessels (HAVs) have shown clinical success and may confer lower susceptibility to infection. Here we directly compared the susceptibility of ePTFE grafts and HAV to bacterial ...
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An Early Study on the Mechanisms that Allow Tissue-Engineered Vascular Grafts to Resist Intimal Hyperplasia
Abstract : Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the study. Intimal hyperplasia in the outflow vein of TEVGs was assessed at ...
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Map of the Month - April
Welcome to Edinburgh Instruments newest blog celebrating our work in Raman, Photoluminescence, and Fluorescence Lifetime Imaging. Every month we will highlight our pick for Map of the Month to show how our spectrometers can be used to reveal all the hidden secrets in your samples. April Studying animal tissue is an important tool for scientists to learn more about the effects of treatments for ...
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New findings! Egr1 is a target for the treatment of fibrotic nephropathy
Epigenetic modifications play a crucial role in various biological processes and diseases, and DNA methylation is an important mechanism of epigenetic inheritance. DNA methyltransferases (DNMT1, DNMT3a, and Dnmt3b) are involved in the generation and maintenance of the epigenome. Specifically, DNMT3a and Dnmt3b are responsible for establishing DNA methylation, whereas DNMT1 maintains ...
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Understanding Pediatric Short Bowel Syndrome
As a parent, you want and hope the best for your children. When your child is diagnosed with a severe condition such as Short Bowel Syndrome, you can feel as if your world has turned upside down. Managing their disease and helping your child lead a better life becomes your top priority. For any parent, the first step in supporting your child is to better understand their disease and the ...
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Treating Peripheral Neuropathy Holistically
In medicine, taking a holistic approach means treating the whole person - body, mind, spirit, and emotions - to achieve one’s optimal health and wellness. For example, if a patient comes in with a sharp, jabbing pain in his hand - a symptom of peripheral neuropathy - a holistic treatment plan may not only include pain relief medicine but also address underlying causes of pain. A holistic ...
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