Melanomas Articles
-
Revealing the molecular mechanism of mutant protein-induced melanoma in the body
The RNA surveillance pathway detects and interprets defective transcripts to ensure RNA fidelity. Recently, in a research report entitled "Oncogenic CDK13 mutations impede nuclear RNA surveillance" published in Science, scientists from Howard Hughes Medical Institute and other institutions discovered a new type of mechanism that affects the occurrence of melanoma, providing broad and important ...
-
Going beneath the surface of skin cancer - Case study
Summary In this Cell Patterns publication, Ozette co-founders and collaborators at the Cancer Immunotherapy Trials Network (CITN) outline a novel method of analysis of single cell data, FAUST, and validate the multiple potential applications. The paper tackles 2 important problems: 1) analysis of complex single cell datasets; 2) prediction of response to immunotherapy in cancer. Manual ...
-
Common Gamma Chain Cytokines in Cancer Immunotherapy
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
By Quartzy Inc.
-
CAR-T Cell Anti-Cancer Therapy Ushered in A Revolutionary Breakthrough!
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. In particular, CAR-T therapy, which has been approved by the FDA, is rewriting the treatment paradigm of some hematological tumors. However, adoptive T cell therapy remains of little success in solid tumors. The main reason is that ...
-
INOVIQ study validates the use of SubB2M as an aid in diagnosing malignant melanoma
Data from 144 tissue samples in the feasibility study demonstrated that SubB2M immunohistochemistry detected melanoma with 91% sensitivity and discriminated between malignant melanoma and benign skin lesions. SubB2M-based immunohistochemistry applications represent a new product opportunity for SubB2M in the $1.9b immunohistochemistry market. INOVIQ Ltd (ASX:IIQ) has successfully completed ...
By INOVIQ Ltd
-
Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
-
Proteins That Provide Key Information to Identify Patients with Poor Prognosis Found
In recent years, immune-based cancer treatment methods have given doctors and patients a lot of hope. Drugs called immune checkpoint inhibitors have provided life-saving benefits to more and more people suffering from melanoma, lung cancer, bladder cancer, and many other types of cancer. Although these drugs are exciting, a frustrating sticking point is that doctors cannot predict who will ...
-
Cancer risk of petroleum workers and residents of oil communities
Increased risk of different cancer types in workers employed in petroleum industries and residents living in oil producing communities by Felix Onyije, Bayan Hosseini, Kayo Togawa, Joachim Schüz, and Ann Olsson Considerable health conditions are caused by environmental pollutants, including emissions from petroleum extraction and refining. They are major sources of environmental and ...
-
What is the true burden of nail infections on patients’ well-being?
Blueberry Therapeutics hopes to make a real difference to the quality of life for people who suffer from skin and nail conditions by curing the symptoms they experience. To do this, it is key to understand exactly what issues affect people with these conditions, how this makes them feel, and how much this impacts their daily way of life. Our most advanced area of research is fungal infection of ...
-
Aelan Cell Technologies publishes new research identifying biomarkers that could serve as companion diagnostics for patients being treated with IL-2
San Francisco, CA –Aelan Cell Technologies, with an international research team, today released a study that reveals that age is a key determining factor in the efficacy of cell-based or pharmacological treatments. The study, published in the advanced online publication of Oncotarget: Gerotarget (Focus on Aging) focused on the effect of age on the interaction of Interleukin-2 (IL-2) ...
-
Arbutin – Natural Skin Whitener
Skin pigmentation variations and discolorations can appear in the form of various dark spots, due to age, acne scars or other conditions, or obtained as a result of the overexposure to the sun’s harmful UV rays. Sometimes freckles, the small dots of highly concentrated skin pigmentation, could also be undesirable. Skin whitening, lightening and bleaching refer to the use of chemical ...
-
The novel mechanism of metastasis inhibition by low-dose whole-body irradiation with gamma-rays
The influence of repeated 0.5 Gy whole-body gamma-ray irradiation on tumour metastasis was examined from the standpoint of tumour invasion in the B16 melanoma pulmonary metastasis model in mice. We confirmed that 0.5 Gy whole-body gamma-ray irradiation (four doses over two weeks) significantly suppressed colony formation in the lungs. In the lung tissue 24 h after irradiation, both the level of ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you