Neonatal Articles
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Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study
Abstract Background: Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality, most of which occurs in low and middle-income countries. The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous ...
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New Approach to Successfully Purify and Characterize Human Neural Stem Cells
Human brain has approximately 171 billion cells, of which slightly more than half (approximately 86 billion) are nerve cells. These 86 billion nerve cells are a diverse cell population with hundreds of specialized types and functions, but all originate from three neural cell lineages--neurons, oligodendrocytes, and astrocytes. All three cell lineages originate from a pool of neural stem and ...
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Research Highlight: Stanford University - Case Study
AdvaitaBio’s IPathwayGuide plays significant role in the research of a Stanford investigator. Stanford University is one of the world’s leading research and teaching institutions. With a 1.69 billion dollar annual sponsored research budget, Stanford has been delivering breakthrough discoveries in numerous domains. For over 6 years, Dr. Linda Yip has been conducting research at ...
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Publication Of Effectiveness In Simulated NICU Environment
Abstract Objective Noise in the neonatal intensive care unit can be detrimental to the health of the hospitalized infant. Means of reducing that noise include staff training, warning lights, and ear coverings, all of which have had limited success. Single family rooms, while an improvement, also expose the hospitalized infant to the same device alarms and mechanical noises found in open bay ...
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The Use of High-Frequency Jet Ventilation in the Management of a Pre-term Infant with Pulmonary Stenosis and Respiratory Distress Syndrome. – A Case Report
The combination of congenital heart disease (CHD) and respiratory distress syndrome (RDS) can present a difficult scenario to manage with conventional mechanical ventilation (CMV). Our patient presented with poor right ventricular (RV) function, and refractory respiratory failure on CMV. High-frequency jet ventilation (HFJV) was used in order to improve ventilation at a similar or lower mean ...
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University College London Hospital, London, UK - Case Study
Introduction Incidence of caesarean section performed at full dilatation is increasing. Delivery can be technically challenging and associated with increased maternal and neonatal morbidity. The objectives of this study were to evaluate local caesarean section rate at full dilatation, assess the indications, review the maternal and neonatal morbidity and identify any training ...
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Pulse Oximetry with Clinical Assessment to Screen for Congenital Heart Disease in Neonates in China: A Prospective Study - Case study
Background Several pioneering studies have provided evidence for the introduction of universal pulse oximetry screening for critical congenital heart disease. I lowever, whether the benefits of screening reported in studies from high-income countries would translate with similar success to low-income countries is unknown. We assessed the feasibility and reliability of pulse oximetry plus clinical ...
By Masimo Corp
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Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit - Case study
Objective: To reduce exposure to hyperoxia and its associated morbidities in preterm neonates. Study design: A multidisciplinary group was established to evaluate oxygen exposure in our neonatal intensive care unit. Infants were assigned target saturation ranges and signal extraction technology implemented to temporally quantify achievement of these ranges. The outcomes bronchopulmonary ...
By Masimo Corp
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What Can Lead to Pediatric SBS?
Pediatric Short Bowel Syndrome (also called SBS or Short Gut Syndrome) generally develops shortly after birth due to an underlying gastrointestinal (GI) condition. The condition then can lead to intestinal surgery, in which part of the short bowel is removed. SBS is a devastating condition where patients struggle to absorb life-sustaining nutrients from their diet due to the surgical removal of ...
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A Rationally Designed Therapeutic Vaccine for Herpes
Founder and CEO, Agustin Fernand of Rational Vaccines that is developing a vaccine for herpes. There is a pandemic raging across the world – and it has nothing to do with a coronavirus. Approximately 500 million people worldwide suffer from genital herpes. Several billion more have an oral herpes infection. Herpes is a life-altering disease that can lead to chronic pain, blindness, and ...
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Harnessing the utility of autoantibodies to overcome challenges associated with clinical development in Systemic Lupus Erythematosus (SLE)
Overcoming issues of heterogeneity in disease classification and enabling new approaches to successful drug development. SLE is an autoimmune disease with a wide range of clinical manifestations. It affects approximately 5 million people worldwide and its prevalence varies in different geographies. SLE accounts for around 70% of all cases of lupus, other forms being cutaneous lupus, ...
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FIGO good clinical practice paper: management of the second stage of labor
Abstract This good clinical practice paper provides an overview of the current evidence around second stage care, highlighting the challenges and the importance of maintaining high-quality, safe, and respectful care in all settings. It includes a series of recommendations based on best available evidence regarding length of second stage, judicious use of episiotomy, and the importance of ...
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Small Wristband Solved the Big Medical Problem
In clinical work, wristband checking is one of the important ways of patient identification, and plays an important role in strict implementation of the checking system. Especially for severe patients, neonates and infants with surgery, coma, unconsciousness and disability, wristband should be worn as the basis for effective checking. And hospitalization number is the only sign that patients do ...
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
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Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis
Abstract Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin α5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site, S651. Active PDE then hydrolyzes antiinflammatory cAMP to ...
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Baby Pod 20 announced
Our original flagship product, the Baby Pod II Infant Transport Device, was developed to fulfil a requirement for a safety-focused, easily manageable solution for inter/intra-hospital transport of neonates, and provide a lightweight and cost-effective solution for when a full transport incubator is not required. In 2017, we launch a new evolution of the Baby Pod, incorporating over a decade of ...
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Effect of maternal obesity and passive smoking on neonatal nucleated red blood cells
Passive cigarette smoking and obesity during pregnancy are risk factors for adverse outcome in infant. Elevated umbilical cord neonatal nucleated red blood cells (NRBCs) have been suggested as a marker of intrauterine foetal hypoxia. Aim to demonstrate whether maternal risk factors during pregnancy are capable of elevating circulating NRBCs measured at birth. We compared the count of NRBCs in the ...
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Transcriptional autoregulation controls pancreatic ptf1a expression during development and adulthood
The basic helix-loop-helix (bHLH) transcription factor PTF1a is critical to the development of the embryonic pancreas. It is required early for the formation of the undifferentiated tubular epithelium of the nascent pancreatic rudiment and then becomes restricted to the differentiating acinar cells, where it directs the transcriptional activation of the secretory digestive enzyme genes. Here we ...
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Analysis of the genome sequence of lactobacillus gasseri atcc 33323 reveals the molecular basis of an autochthonous intestinal organism
This study presents the complete genome sequence of Lactobacillus gasseri ATCC 33323, a neotype strain of human origin and a native species found commonly in the gastrointestinal tracts of neonates and adults. The plasmid-free genome was 1,894,360 bp in size and predicted to encode 1,810 genes. The GC content was 35.3%, similar to the GC content of its closest relatives, L. johnsonii NCC 533 ...
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