Renal Care Articles
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Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2
The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strategy for development of broad-spectrum antivirals. By inhibiting the Raf/MEK/ERK signaling pathway, ...
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The Importance of Organ Donation
Why should you donate organs? Organ donation is a way to save the lives of people who are sick, not healthy and in need of new organs. When someone’s organs are weak, they require a new one to continue living. Organ donation refers to the supply of a healthy organ, gained from either a living or passed away donor, to help an individual requiring a transplant to improve ...
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Unravelling the Hypertension Puzzle
In this busy and crowded world, no one has the time or energy to look after themselves; our lack of effort and diminished sense of responsibility towards our health has led to stress, tension, and various health issues becoming an inseparable part of our lifestyle. One of the most popularly spread health issues is hypertension. According to estimates by The World Health ...
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Research Progress of Tetrahydrocurcumin
Tetrahydrocurcumin (THC), as the most active and main metabolite produced in the metabolism of curcumin in vivo, can be isolated from the cytoplasm of the small intestine and liver after curcumin administration in human or mouse. Tetrahydrocurcumin can effectively inhibit tyrosinase, inhibit the generation of Oxygen Free Radicals and scavenge the formed free radicals. It has obvious antioxidant ...
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How can Nuvonis help to fight the SARS-CoV-2 pandemics?
At the end of the year 2019, a cluster of severe pneumonia of unknown cause was described in Wuhan (Eastern China) and a SARS-like acute respiratory distress syndrome (ARDS) was noted in these patients. Early in January 2020, sequencing revealed a novel coronavirus (now termed SARS-CoV-2) as the causal factor for the disease designated as COVID-19. The pandemic caused by the virus has unforeseen ...
By Nuvonis
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What are Vero cells?
Vero cellsare a continuous adherent cell line that is frequently used in cell culture and plays an important role in worldwide vaccine and vector production (manufacturing). Unlike other mammalian cells, they do not secrete interferon alpha or beta when infected by viruses – this is one of the reasons that efficient replication of many viruses can be achieved in Vero cells, ...
By Nuvonis
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Common Gamma Chain Cytokines in Cancer Immunotherapy
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
By Quartzy Inc.
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Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure
Abstract Acute decompensated heart failure remains the most common cause of hospitalization in older adults, and studies of pharmacological therapies have yielded limited progress in improving outcomes for these patients. This has prompted the development of novel device–based interventions, classified mechanistically based on the way in which they intend to improve central hemodynamics, ...
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Spine-Intra-Abdominal Pressure (SIAP) - Case Study
The SIAP study investigates the effect of using Ergotrics' Inflatable Prone Support (IPS) on intra-abdominal pressure (IAP) during spine surgery. Study background The objective of this study is to demonstrate the ability of the inflatable Prone Supports (IPS) to lower the IAP of patients in the prone position. Whenever the patients’ position is changed to prone, the IAP is increased due to ...
By Ergotrics NV
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How The Pelvic Floor Therapy System Can Help Improve your Health
The pelvic floor physical therapy system is a therapeutic method that uses physical therapy concepts to recondition the pelvic floor muscles in a systematic, effective, and safe manner. The treatment’s purpose is to increase the strength and function of the pelvic floor muscles, as well as to relieve discomfort, weakness, and inefficiency. A qualified physical therapist accesses the muscles ...
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New findings! Egr1 is a target for the treatment of fibrotic nephropathy
Epigenetic modifications play a crucial role in various biological processes and diseases, and DNA methylation is an important mechanism of epigenetic inheritance. DNA methyltransferases (DNMT1, DNMT3a, and Dnmt3b) are involved in the generation and maintenance of the epigenome. Specifically, DNMT3a and Dnmt3b are responsible for establishing DNA methylation, whereas DNMT1 maintains ...
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Galectin 3 Inhibition Attenuates Renal Injury Progression in Cisplatin-Induced Nephrotoxicity
Annotations Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury Inhibition of Gal-3, mediated by MCP, antagonized the pro-apoptotic (cell death) effects. MCP- treated mice demonstrated increased renal function and reduced renal fibrosis after cisplatin- induced MCP-treated ...
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California Prop65 list
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
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The Power Of RepliGut in Vitro Intestinal Stem Cell Models
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. RepliGut®, an in vitro human intestinal epithelial stem cell model, addresses many of these issues and has significant potential to reduce the time and cost of drug development. This model may even help to identify optimal therapies for ...
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A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury
Abstract Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI. Methods: Among fifty-two post-cardiac surgery patients, serum and urine Gal-3 levels were examined on intensive care unit (ICU) admission. In a rat renal I/R ...
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Cancer risk of petroleum workers and residents of oil communities
Increased risk of different cancer types in workers employed in petroleum industries and residents living in oil producing communities by Felix Onyije, Bayan Hosseini, Kayo Togawa, Joachim Schüz, and Ann Olsson Considerable health conditions are caused by environmental pollutants, including emissions from petroleum extraction and refining. They are major sources of environmental and ...
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6 Tips for Maintaining Healthy Bladder Function With Incontinence
The bladder affects your day-to-day wellbeing. Sadly, many people don’t give much thought to a healthy bladder. Each day, an health adult will pass about a quart and a half of urine. When an adult involuntarily leaks urine it is called urinary incontinence. Incontinence can occur among adults of all ages, and there are three major types; stress, urge and mixed. This guide provides ...
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How to Treat a Leaky Bladder: A Guide for Women
It happens to the best of us — an unexpected sneeze or giggle and suddenly you are made aware that you have a leaky bladder. As difficult as these situations can be, there’s nothing to be embarrassed about. According to one study, 45 percent of women between the ages of 20 and 80 experience some degree of urinary incontinence. Luckily, there are steps you may take to regain ...
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3 Things That Google’s Healthcare Artificial Intelligence Desperately Needs
Google DeepMind recently published a paper in Nature that shared how their predictive algorithm can detect Acute Kidney Injury (AKI) up to 48 hours in advance. Acute Kidney Injury is the biggest problem you have never heard of. In the US, 1 in 5 hospitalized adults gets Acute Kidney Injury, resulting in a 5x risk of death. It takes the lives of over 300,000 Americans every year. Globally, the ...
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The Role of Lactate in Sepsis Research
Sepsis reportedly affects up to 30 million people each year. Lactate levels play a key role in diagnosing the condition and limiting its impact, as well as researching it's progression and developing possible treatments. Here's how. Sepsis is a medical condition and emergency, the definition of which has proven difficult and is based on fairly recent developments and research. It is the result ...
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