Reproductive Medicine Articles
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Cryopreservation Process, Methods and Storage Solution Explored
The Cryopreservation Process The Cryopreservation Process is where biological matter (cells, tissue, organs, etc) is preserved by cooling to a very low temperature. This process stops the normal cell functions and holds the sample in suspended animation. When the time comes to thaw the sample, normal biological function resumes.Cryopreservation Process Steps The cryopreservation process can be ...
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How does your Vaginal Microbiome Affect your Cancer Risk?
When you hear about the vaginal microbiome (VMB), your first thought may be the role it plays in stuff like yeast infections or bacterial vaginosis (BV). But with improved research, we’re uncovering more of the VMB’s long-term effects, like its role in a healthy pregnancy and delivery. The complex community of organisms living in your vagina even plays a part in your risk of ...
By Juno Bio
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How 4D Path and PathPresenter aim to further AI-enabled digital pathology for breast tumor profiling
The digital pathology software company PathPresenter (Montville, New Jersey) and the precision oncology platform firm 4D Path have entered into a partnership that could improve the diagnostic accuracy of breast tumor profiling. PathPresenter has developed a digital workflow tool for clinicians, pathologists and pharma companies to aggregate medical data. ...
By 4D Path Inc.
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ART and the Vaginal Microbiome
The link between the vaginal microbiome and pregnancy outcomes is so strong that someone’s vaginal microbiome can actually be used to predict IVF success What is the vaginal microbiome? Your vaginal microbiome is the community of microbes living in your vagina. A healthy vaginal microbiome typically has low diversity and is dominated by a type of good bacteria called Lactobacillus that ...
By Juno Bio
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Detailed Introduction to Steroids Analysis
Steroid hormone is a class of compounds that contain cyclopentane polyhydrophenanthrene structure formed by cholesterol and catalyzed by cytochrome P450 enzymes. Steroid hormones mainly include adrenocorticotropic hormones secreted by the adrenal cortex and sex hormones secreted by the gonads, which are mainly divided into four categories: progesterone, corticosteroid, estrogen and androgen. ...
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Learn the Properties and Applications of Chymotrypsin
Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals. ...
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California Prop65 list
1. Tetrahydrocannabinol (THC) Tetrahydrocannabinol (THC) is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom since 2010 as a mouth spray for people with multiple sclerosis to reduce neuropathic pain, spasticity, overactive bladder, and other symptoms. Nabiximols (as Sativex) is available as a prescription drug in ...
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Q&A with Dr. Veronica Iatarola Antas, Research Scientist and Project Lead at Regeneus
Q. Tell us about your role as a Research Scientist and Project Lead at Regeneus? A. My role is extremely diverse and has evolved over my time at Regeneus. Initially, I was responsible for optimising our product manufacturing processes, including manufacturing products for our preclinical and clinical trials. For example, I provided the data to support preclinical studies that evaluated ...
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Infectious Hypodermal and Haematopoietic Necrosis Virus (IHHNV) (Part 2)
This virus was first discovered in P. vannamei and P. stylirostris in the America, starting in Hawaii. However, it was probably not an indigenous virus, but was thought to have been introduced along with live P.monodon from Asia. IHHNV has probably existed for some time in Asia without detection due to its insignificant effects on P. monodon, the major cultured species in Asia, meaning that ...
By Vinnbio
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Chronic exposure to mono‐(2‐ethylhexyl)‐phthalate causes endocrine disruption and reproductive dysfunction in zebrafish
Phthalic acid esters are frequently detected in aquatic environment. In this study, zebrafish were exposed to low concentrations (0, 0.46, 4.0, and 37.5 µg/L) of mono‐(2‐ethylhexyl) phthalate (MEHP) for 81 days, and the effects on reproduction, gamete quality, plasma vitellogenin (VTG), sex steroids, and transcriptional profiles of key genes involved in steroidogenesis were investigated. The ...
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Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm
Bisphenol A acts as an endocrine disruptor, affects animal reproductive success in vivo, and affects sperm functions in vitro at environmentally relevant concentrations leading to reduction in sperm motility and fertilizing ability in fish. The effect of in vitro BPA on avian sperm functions has not been explored. We tested the effect of environmentally relevant concentrations of BPA (0, 0.18, ...
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Effects of progesterone and norethindrone on female fathead minnow (Pimephales promelas) steroidogenesis
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen (progesterone, 34 ± 4.1 ng/L) on steroidogenesis in adult female fathead minnows ...
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Assessment of multiple hormonal activities in wastewater at different stages of treatment
Changes in the endocrine potency of municipal wastewater at 3 wastewater treatment plants (WWTPs) in Australia were investigated using a panel of in vitro receptor‐driven transactivation assays. The assays were based on human estrogen receptor α, androgen receptor, progesterone receptor, glucocorticoid receptor, and peroxisome proliferator‐activated receptor γ2. Total removal efficiencies for ...
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Effects of triclocarban, deet and a mixture of pharmaceuticals and personal care products on fathead minnows (Pimephales promelas)
Pharmaceuticals and personal care products (PPCPs) have been detected widely in aquatic ecosystems, but little is known about their mechanisms of toxicity. We exposed adult fathead minnows (Pimephales promelas) for 48 hours to triclocarban (1.4 µg/L), DEET (0.6 µg/L) or to a PPCP mixture consisting of atenolol (1.5 µg/L), caffeine (0.25 µg/L), diphenhydramine (0.1 µg/L), gemfibrozil ...
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Seasonal and sex-related variations in serum steroid hormone levels in wild and farmed brown trout
Salmo trutta L. in the north-west of SpainSerum steroid profiles were investigated in order to evaluate the potential use of circulating sex steroid levels as a tool for sex identification in brown trout. Changes in the serum concentrations of testosterone (T), progesterone (P), 17-β-estradiol (E2), and cortisol (F) in wild and farmed mature female and male brown trout, Salmo trutta L., were measured in each season (January, ...
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Imposex and novel mechanisms of reproductive failure induced by tributyltin (TBT) in the freshwater snail Pomacea canaliculata
The effects of TBT on mortality and reproduction were studied in this invasive snail. The nominal fifty percent lethal concentration (LC50) was 9 µg TBT/L, after 28 days. The nominal ‘no observed effect on lethality concentration’ (NOECL) was 6 µg TBT/L after the same period. Male‐female couples and females that had been group‐mated but were isolated from males during the experiment (isolated ...
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Norfloxacin drug induces reproductive toxicity and alters androgen receptor gene expression in testes and cloacal gland of male Japanese quail (coturnix japonica)
Attempts have been made to investigate the reproductive toxicity of norfloxacin drug in Japanese quail. Male quail were administered with norfloxacin @ 20 mg/kg body weight for 14 days. Then reproductive functions and androgen receptor (AR) gene expression was examined in treated and control birds. The results of the present study indicated that fertility, cloacal gland area, sperm ...
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Unraveling a municipal effluent's toxicity to Tripneustes gratilla sperm fertilization
A tiered investigative approach was employed to characterize and identify substances responsible for the persistent toxicity of a municipal primary‐treated effluent to gametes of the Hawaiian sea urchin, Tripneustes gratilla. EPA Toxicity Identification Evaluation (TIE) procedures were modified to account for the tolerance of T.gratilla gametes to various sample manipulations. Microtox rapid ...
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Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A
Adverse effects of bisphenol A (BPA) on male reproductive physiology were studied in male goldfish (Carassius auratus) exposed to nominal environmentally relevant concentrations (0.2 and 20 µg/L) for up to 90 d. Transcriptions of various reproductive genes were measured in brain, liver, and testis to investigate the BPA modes of action. Volume, density, total number, and motility and velocity of ...
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Impairments in aromatase expression, reproductive behavior, and sperm quality of male fish exposed to 17β‐estradiol
Growing evidence shows that environmental estrogen can reach levels that are high enough to exert adverse reproductive effects on wild fish populations. The authors report different parameters of male reproductive behavior, brain, and gonadal aromatase expression, as well as sperm quality in an internally fertilizing fish species (Jenynsia multidentata, Jenyns) exposed to environmentally relevant ...
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