Rheumatology Articles
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Nanobodies Definition, Structure, Advantages and Applications
What is a Nanobody?Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages. The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in ...
By BOC Sciences
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Diabetomics Lumella - New Point-of-Care Blood Test Kit for Early Detection of Preeclampsia
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. We recently reported that many RA patients have anti-citrullinated albumin (ACA) ...
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Unveiling The Manifold Potentials: Mesenchymal Stem Cells & Bone Marrow Mesenchymal Stem Cells
In the vibrant realm of cellular biology and regenerative medicine, mesenchymal stem cells (MSCs) hold unparalleled potential for therapeutic applications. Particularly noteworthy are bone marrow mesenchymal stem cells (BM-MSCs), a subtype of MSCs. Their unique properties make them indispensable resources for developing ground-breaking solutions for various medical conditions. Mesenchymal stem ...
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CD19: One of The Most Important Targets for Car-T Cell Therapy
What is CD19 Understanding CD19: Definition and Role in the Immune System CD19, also known as Cluster of Differentiation 19, is a cell surface protein belonging to the immunoglobulin superfamily. It serves as a crucial marker for B cells, playing a pivotal role in the human immune system. While predominantly found on the surface of B cells, CD19 is rarely expressed on other immune cells. Its ...
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Breakthrough Innovations in Bipolar Hip Prosthesis: Improving Mobility and Stability
Hip replacement surgery has been a life-changing procedure for individuals grappling with debilitating hip conditions like osteoarthritis, rheumatoid arthritis, or hip fractures. Over the years, continuous strides in medical technology have ushered in substantial enhancements in hip prostheses, offering patients the prospect of regaining mobility, alleviating pain, and improving their overall ...
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How Much Do You Know about Cocklebur Plant?
What is Cocklebur? Xanthium strumarium is a flowering plant belonging to the Asteraceae family. It is an annual herb known for its rough, oval spines covered in hooked spines. These burrs easily attach to clothing, fur, and feathers, allowing the plant's seeds to disperse over long distances. It is considered a noxious weed in some areas due to its toxicity and impact on agriculture. The seeds ...
By CD BioGlyco.
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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The Role of MMP-3: Insights into Disease Progression and Therapeutic Potential
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular ...
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Unraveling the IL-17 Family and its Receptor Complex: Key Players in Immune Responses
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli ...
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Understanding IL-36 Cytokines: Their Role & Potential in Treating Inflammatory Diseases
Introduction to IL-36 Family Twenty years ago, Interleukin 36 (IL-36) was discovered as a member of the IL-1 superfamily. Its gene is located on chromosome 2 in an IL gene cluster, including IL1A - IL1B - IL37 - IL36G - IL36A - IL36B - IL36RN - IL38 - IL1RN, with IL-36 encoding genes transcribed far away from the centromere. There are four known subtypes of IL-36, which have been renamed multiple ...
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Relieving Chronic Pain in a Diverse Workforce - Manatee County - Government - Case Study
Fearing Pain Tracie is a 52 year old Human Services Program Manager at Manatee County. Sitting at her desk all day, she began to experience knee pain 4 years ago. Her orthopedic specialist diagnosed her with osteoarthritis. He withdrew fluid, injected cortisone, and advised her to avoid things like walking up stairs. She began to avoid activity but the pain persisted until she was taking 8 ...
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Project - Sublingual IL2 (BL SLIT I)
The aim of this project is to develop low dose IL-2 for treatment of early onset juvenile Type I diabetes. Low dose injectable IL-2 in animal models has been shown to restore the balance between regulatory and effector T cells and, in this way, can help to reverse autoimmunity and the development of type I diabetes. Looking ahead, we anticipate that having a suitable oral formulation of IL-2 to ...
By BioLingus AG
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What are Surgical Options for ACL Tears?
The anterior cruciate ligament, better known as the ACL, is one of the two ligaments in the center of your knee that connect the femur to the tibia. It’s also one of the most commonly injured, especially among athletes. Unlike many other ligaments in the body, the ACL does not have the ability to heal on its own. A thick liquid – called synovial fluid – reduces friction ...
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A New Concept of Mosaicplasty: Autologous Osteoperiosteal Cylinder Graft Covered With Cellularized Scaffold
Abstract: A concern regarding osteochondral autograft transfer for chondral defects is donor-site morbidity of the knee, the most common source of the autograft. To avoid the drawbacks of osteochondral autograft transfer, a cylindrical osteoperiosteal graft harvested from the iliac crest covered by a same-sized cylinder of hyaluronic acidebased polymer scaffold pretreated with bone marrow ...
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A new perspective regarding laser therapy
In April of this year, prior to the beginning of our International Conference in Toronto, I had the rare opportunity to meet for several hours with Tiina Karu, Mary Dyson, Shimon Rochkind, Chukuka Enwemeka and several other leading authorities involved in the field of laser technology. Whereas their interests encompass basic research, pathology, tissue response mechanisms and clinical ...
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Treatment for shoulder pain - Case Study
Treatment for shoulder pain Gabi Zeilig, MD, Dept of Neurological Rehabilitation The Chaim Sheba Medical Center, Tel Hashomer, Israel. Purpose of the study: to test the efficacy of the TerraQuant medical device on shoulder pain resulting from inflammation (OA, Tendonitis, Bursitis). Background: TerraQuant is a unique device which combines low level pulse laser therapy (LLLT), pulsating ...
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Applications of Cell-penetrating Peptides
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides ...
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Hip and knee osteoarthiritis cases are on the rise
Depending on the severity, osteoarthritis (OA) can be a seriously debilitating condition. This is particularly true when it takes effect on an individual’s hips or knees, joints that are essential for basic mobility. 2017 data published in the Annals of the Rheumatic Diseases by Saeid Safiri, PhD, of Tabriz University of Medical Sciences, and his colleagues, shows a consistent and ...
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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Therapeutic Massage for Arthritis in Pets
As most of you know by now, arthritis is one of the most common diseases that afflicts pets. In fact, according to most estimates, 1 in 5 dogs is affected by osteoarthritis. Additionally, it is estimated that 40-92% of cats are affected by arthritis. There are numerous potential treatment modalities for arthritis including medications, rehabilitation, and even VetStem Cell Therapy. Another ...
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