Molecular Medicine Articles

The Big Picture: GE Healthcare`s Latest Acquisition Could Help Open a New Chapter in Precision Health

Julia Casey is a biochemical engineer by training, but she is also a dealmaker at heart. “I like doing deals,” says Casey, who serves as general manager of GE Healthcare’s Pharmaceutical Diagnostics Molecular Imaging business. “I like dealing with startups and thinking how we can leverage their skills and bring them in so we can really see the benefits of everything ...

May 28, 2021

By GE Renewable Energy

Creative Enzymes Launches Advanced Neuraminidase for Flu Vaccine Development

Creative Enzymes, a professional enzyme provider located in New York, always hammers at researches and trials in order to provide customers with various enzymes as many as possible. Last week, the product manager of Creative Enzymes announced the launch of neuraminidase, which is expected to further develop a new universal influenza vaccine. Neuraminidase is a drug target to prevent the spread ...

May 5, 2021

By Creative Enzymes

Top 5 challenges facing OBGYNs

Although clinicians aim to provide the best service possible, OBGYNs worldwide continue to face widespread obstacles in delivering treatment. We spoke with international experts to hear their input on the five biggest challenges facing OBGYNs around the world. Fear of treatment and diagnosis For many women, psychological factors, such as fear of painful tests and anxiety of diagnosis, play a ...

Apr. 13, 2021

By MobileODT

Chimeric Molecules as Adversarial Training Examples for Machine Learning

Abstract The application of machine learning techniques to cheminformatics data has accelerated tremendously in recent years. In particular, deep learning architectures show considerable promise in being able to extract patterns and features from large datasets that aren’t readily obvious to human experts or apparent with hand-crafted features. With this larger modeling capacity comes ...

Apr. 2, 2021

By Atomwise Inc.

Structure-Based Drug Design with Multi-Task Learning and Data Augmentation

Abstract With rapid advances in machine learning methods and the availability of vast amounts of chemical data, structure-based drug design is at the dawn of a golden age. The tremendous successes of deep learning methods in the fields of natural language processing, speech recognition and computer vision have set the expectation for these emerging technologies to successfully target undruggable ...

Apr. 2, 2021

By Atomwise Inc.

RARE ANSWERS™: A System to Improve Patient Outcomes - Case study

At Alexion, our mission is to transform the lives of people affected by rare diseases and devastating conditions. In addition to developing and delivering life-changing medicines, this mission drives us to seek opportunities to advance innovative solutions to system-wide challenges faced by rare disease patients, such as the “diagnostic odyssey.” What is the Diagnostic Odyssey? ...

Mar. 26, 2021

By Alexion Pharmaceuticals, Inc.

High Throughput SHERLOCK CRISPR SARS-CoV-2 Test

Abstract: The ability to control the spread of COVID-19 has been hampered by a lack of rapid, scalable, and easily deployable diagnostic solutions. Efforts to increase testing capacity have been adversely impacted by supply chain challenges due to dependencies on a limited set of reagents, consumables, and instrumentation. Here, we present a diagnostic method based on CRISPR (clustered regularly ...

Mar. 25, 2021

By Sherlock Biosciences

Optimized Solutions for Plasmid- DNA Clarification and Purification

FILTRODISC BIO SD is the state-of-the-art technology for alluvial filtration for Plasmid-DNA clarification. It is based on depth filters that capture contaminants in their three-dimensional matrix. The used PURAFIX depth filters are low in extractable ions and pyrogens. By adding filter aid, such as diatomaceous earth, the capacity per m2 filter area can be drastically ...

Jan. 11, 2021

By Filtrox AG

Brain Imaging in Zebrafish

An adult human brain contains approximately 86 billion neurons, along with about 85 billion non-neuronal cells. All those cells work together to manage motor control, sensory perception, heart rate, breathing, and more. While the human brain is extremely complex, with the ability to process language, it is not totally unique. Most vertebrate brains are quite similar; they all need similar ...

Jun. 4, 2020

By Powers Equipment Company, Inc.

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

A population of NK cells expressing the activating receptor NKG2C and the maturation marker CD57 expands in response to human CMV (HCMV) infection. CD3–CD56dimCD57+NKG2C+ NK cells are similar to CD8+ memory T cells with rapid and robust effector function upon restimulation, persistence, and epigenetic remodeling of the IFNG locus. Chronic antigen stimulation drives CD8+ memory T cell ...

Jun. 18, 2019

By Johnson Controls, Inc.

Bacteriophage M13 and Plasmid DNA pUC1

Given the height of the bacteriophage M13 (3-4 nm), a single bacteriophage may have been imaged at 1720 cm-1 (C=O) and 1667 cm-1 (amide I) via PiFM. As is the case in many instances, PiFM images reveal features that are not clear in ...

Mar. 29, 2019

By Molecular Vista

LLNL Uses 3D Bioprinting to Produce Live Cells

On March 5, 2019, the Lawrence Livermore National Laboratory (LLNL) announced that their researchers have 3D printed live cells that are able to convert glucose to ethanol and carbon dioxide gas. The substance produced from this conversion resembles beer. This means that this newly developed technology can lead to highly efficient biocatalysis. According to LLNL’s announcement, the use ...

Mar. 15, 2019

By Bergeson & Campbell, P.C.

Degradation of splicing factor SRSF3 contributes to progressive liver disease

Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), ...

Aug. 8, 2018

By Johnson Controls, Inc.

ELITe InGenius a new Molecular Diagnostics Sample-to-Result solution and first fully automated sample-to-result solution introduced with transplant monitoring menu

ELITe InGenius is an integrated sample to-result solution dedicated to Molecular Diagnostics which automatically performs extraction, amplification and result interpretation with an unprecedented flexibility and assay menu possibility. The system combines a universal extraction process in unitary cartridge with individual and independently controlled RT PCR in cassette based format enabling the ...

Nov. 19, 2016

By ELITechGroup

Lost in transit: long-distance trafficking and phloem unloading of protein signals in Arabidopsis homografts

In addition to moving sugars, and nutrients, the phloem transports many macromolecules. While grafting and aphid stylectomy experiments have identified many macromolecules that move in the phloem, the functional significance of phloem transport of these remains unclear. To gain insight into protein trafficking, we micrografted Arabidopsis thaliana scions expressing GFP-tagged chloroplast transit ...

Sep. 6, 2016

By H Smith Plastics LTD

A Functional Link Between Mitochondria and the Cell Wall in Stress Responses

Both mitochondria and the cell wall are targeted by and respond to stresses. The cell wall is physically affected by abiotic stresses and is the site of initial attack by pathogens. During stress responses, the cell wall is remodeled to maintain integrity and allow flexibility (reviewed in Hamann, 2015; Tenhaken, 2015). Similarly, stresses can alter mitochondrial function, especially in terms of ...

Sep. 6, 2016

By H Smith Plastics LTD

Degradation of nicosulfuron by a novel isolated bacterial strain Klebsiella sp. Y1: condition optimization, kinetics and degradation pathway

A novel bacterial strain Klebsiella sp. Y1 was isolated from the soil of a constructed wetland, and it was identified based on the 16S rDNA sequence analysis. The co-metabolic degradation of nicosulfuron with glucose by Klebsiella sp. Y1 was investigated. The response surface methodology analysis indicated that the optimal pH and temperature were 7.0 and 35 °C, respectively, for the ...

Mar. 17, 2016

By IWA Publishing

Isolation and partial characterization of a new strain of Klebsiella pneumoniae capable of high 1,3 propanediol production from glycerol

Glycerol is a promising feedstock for microbial cultivation and production of 1,3 propanediol (1,3 PDO). Here we report a newly isolated bacterial strain BA11 from soil, capable of fermenting glycerol to 1,3 PDO, and has been identified to be a strain of Klebsiella pneumoniae. Strain BA11 was fast growing showing peak 1,3 PDO production in 6 h of cultivation with productivity of 1.2 g/L-h without ...

Feb. 9, 2015

By GJESM Journal

How magnets act with electromagnetic impulses

Researchers are now engaged in exploring the various alternative remedies to treat the general health related issues. Magnet therapy is one amongst the all. Since the ancient times people were aware of the health benefits of Magnet. Treating various physical illnesses with the help of magnet is known as Magnetic Field Therapy. The magnetic field has a great affect on human body. A proper balance ...

Jul. 21, 2014

By Stanford Magnets

Antibiotic resistance among autochthonous aquatic environmental bacteria

Antibiotics are widely used in both human and veterinary medicine and antibiotic-resistant bacteria cause problems in antibiotic therapy. The current study was conducted in the catchment area of the river Swist (Germany) and focuses on the resistance of environmental Rhodospirillaceae to antibiotics used in human medicine. The samples collected reflect different levels of human impact on the ...

Nov. 6, 2012

By IWA Publishing