Neurology Articles
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Signs of Parkinson’s Disease to Watch For
Parkinson’s disease is a progressive neurodegenerative disease that is most commonly known for affecting movement. It primarily impacts dopaminergic, or dopamine-producing, neurons in a specific area of the brain known as the substantia nigra. Typically, symptoms develop slowly over years and continue to worsen as the disease progresses. While the manifestation of symptoms tends to vary ...
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Breakdown of How Sugar Impacts The Brain and Cognitive Function
It is no secret that glucose, a form of sugar, is the main source of energy for every cell in our bodies, including our brain cells. Because the brain is packed with neurons, it uses more energy than any other organ in the body. Our brains reward us for consuming sugar. Whether you are eating a delicious meal, sharing a kiss with someone you love, or enjoying a sugary treat, the mesolimbic ...
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What are Strongyloides?
Strongyloides is an opportunistic pathogenic parasitic nematode. Adults parasitize in the small intestine of cats, dogs and humans. The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. The disease is mainly prevalent in warm and humid tropical and subtropical regions. In recent years, due to the continuous increase of HIV/AIDS infection rate in ...
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How to Measure Cognitive Decline In Older Patients
Primary care practitioners are often the first to address a patient’s or family’s concerns about memory loss or the possibility of dementia. Detecting cognitive decline as early as possible is fundamental to a patient’s ability to receive earlier access to treatments and therapies, and, consequently, more effective treatment and improved health outcomes. There are several ...
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Family Focused Wellness: The Past, Present, and Future of Genetics and Fitness
Bill B. has always drawn inspiration from family to live a healthy and active lifestyle. From his grandfather, to his daughters, to his ’running-family’ he’s now sharing the transformative power of genetic insights with others to help improve the wellness of generations to come. This is Bill’s #Orig3nStory Thanks for joining us today Bill. We enjoyed meeting you at a ...
By Orig3n
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In the NFL `Afterlife` everything hurts
Not too long ago in the August 4th version of the San Jose Mercury News, reporter Elliott Almond caught up with NFL Hall-of-Fame quarterback Jim Plunkett to talk about life after football. His response made headlines. "My life sucks", said Plunkett, now 69. "It’s no fun being in this body right now. Everything hurts." The years of daily pain pulsating from the neck, back, knees, ...
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Pain and the Endocannabinoid System, A Physicians Perspective
The topic of pain and pain control is a very complex one with many different areas of concern and consideration. I will try to outline this complex topic as it applies to the endocannabinoid system. In my last article I briefly outlined this system and described it as an internal “buffer” the main function of which is to create homeostasis within our body. When considering the ...
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The Endocannabinoid System, A Physician`s Perspective
Most physicians are constantly learning not only for their benefit but, more importantly, for the benefit of their patients. It is not surprising therefore that there is considerable interest in the endocannabinoid system (ECS) as this system has only been recently recognized and appreciated. I think it is fair to say that over the last decade there has been more interest in the ECS than any ...
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Titanium but not just titanium
Titanium and its alloys have many advantages as surgical implant materials, such as low density, high strength, good toughness, good biocompatibility, non-toxicity, low elastic modulus, good corrosion resistance, and low X-ray absorption rate Etc., thus occupying an increasingly important position in medical metal materials. Titanium and its alloys can be used for the repair and replacement of ...
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LncRNA Sequencing Helps to Find Deep Links to Disease
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those ...
By CD Genomics
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The Link Between Smoking and Cognitive Decline
By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...
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Keep Your Heart Healthy During the Holidays!
As we prepare for this holiday season, with an extra dose of joy and elation, please keep in mind what overindulgence can do to your heart health, even in a relatively short period of time. You shouldn’t be surprised to learn that during the holiday season, when we not only tend to overindulge the most but also stress levels are typically the highest, there is a 33% increase in heart ...
By BIOLIFE4D
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Programmed Drug Release of rhBMP-2 for Bone Healing
Summary: Non-union of bone fractures can cause pain and disabilities. Amongst certain fracture types, in specific age groups, the incidence of non-union is over 8% in the United States and over 3.6% of all fractures in the UK. Fracture non-unions have lifelong consequences and a debilitating impact in patients' life. Bone-grafts, allografts and xenograft are currently used to treat bone ...
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Cell-Penetrating Peptides: Features, Mechanisms, Applications
Cell-penetrating peptides (CPPs) refer to water-soluble, partly hydrophobic, and/or polybasic short peptides that are fewer than 30 amino acids in size. Different types of CPPs like chimeric peptides and hydrophobic peptides have different lengths, charges, solubility, and hydrophobicity. At current, cell-penetrating peptides are often classified in line with their characteristics, including ...
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Luminex Multiplex Assay
Principle of Luminex Multiplex Assay Luminex xMAP technology uses polystyrene microspheres of 5.6 microns in diameter dyed with different ratios of two red-sorting fluorescent dyes to obtain up to 100 fluorescent coded microspheres. Antibody molecules or gene probes for different test items are covalently cross-linked to specific coded microspheres, each of which corresponds to a specific test ...
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Mitochondrial Proteomics
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. ...
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The Pivotal Glutathione Reductase
Glutathione is a tripeptide containing sulfhydryl groups combined with glutamic acid, cysteine and glycine. Glutathione has two forms, reduced (G-SH) and oxidized (G-S-S-G), and reduced glutathione accounts for the vast majority under physiological conditions. Glutathione reductase catalyzes the interconversion between the two types. The coenzyme of this enzyme is NADPH provided by the ...
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Research Shows a Link Between Loneliness and Dementia
Humans are inherently social beings who thrive on making and maintaining social relationships. Connecting with and supporting one another forms deep bonds that make us feel seen, valued, and like we belong. These social interactions are not only important for our emotional well-being but also for our physical well-being-maybe even more so than originally thought. Loneliness, an increasingly ...
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Transcutaneous Magnetic Stimulation (tMS) in Alleviating Post-Traumatic Peripheral Neuropathic Pain States - Case Study
Abstract Background. Peripheral nerve injury can result in the formation of neuroma/nerve entrapment, a persistent peripheral neuropathic pain state which is often refractory to invasive interventions or medications. Therefore, there is a need in the field of pain management to develop innovative noninvasive therapy in treating post-traumatic peripheral neuropathic pain states. A new ...
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Effect of Low FrequencyTranscutaneous Magnetic Stimulation on Sensory and Motor Transmission - Case Study
INTRODUCTION After a peripheral nerve injury, fast conducting large myelinated afferent A-bcta fiber transmission diminishes over time. On the other hand, firing of smaller pain transmitting fibers such as A-dclta and C-fibcrs is enhanced. This aberrant afferent neuronal behavior is thought to be one of the main neuronal mechanisms leading to development of chronic posttraumatic peripheral ...
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