Neurodegeneration Articles
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Drug Discovery: Unraveling the Mysteries of Therapeutic Agents
In the vast and ever-evolving field of medicine, the discovery of new drugs has been a critical pursuit, offering hope and relief to countless individuals suffering from various ailments. The process of drug discovery is a complex and multifaceted endeavor, involving the integration of diverse scientific disciplines, including biology, chemistry, and computational science. At the heart of this ...
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What Is Metabolomics?
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including the detection and analysis of metabolite types and quantities and ...
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Unveiling the Role of CD73: A Key Player in Immune Regulation and Beyon
What is CD73? CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked ...
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Nano-Flow Cytometry: A Revolutionary Tool for Biomedical Research
Nano-flow cytometry is a revolutionary technology that has the potential to transform early disease detection and diagnosis. Nano-flow cytometers are able to detect and analyze individual nanoparticles, including extracellular vesicles and viruses, with high sensitivity and accuracy. This makes them ideal for detecting diseases at their earliest stages, when they are most treatable. How does ...
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The Principles, Features and Applications of BioID
What is BioID Technique? BioID (proximity-dependent biotin identification) is a proximity dependent labeling technology established by Roux et al in 2015 to study protein interactions. It can also be developed to study the interactions between proteins and RNA, and proteins and DNA. How BioID technology works? A recombinant expression vector of the target protein with biotin ligase (BirA) is ...
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Understanding Drug-Disease Relationship Analysis: A Key to Drug Discovery
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
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The Role of Chx10 Neurons in Global Motor Arrest
A recent study by Goni-Erro et al (2023) in Nature Neuroscience has shed light on a fascinating phenomenon: the neural control of global motor arrest. From the cessation of goal-directed actions to a broader motor arrest in response to fear or environmental cues, this complex behavior involves an intricate set of neuronal pathways. This recent study reveals that the activation of ...
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Bioconjugation Strategies for Enhancing Drug Delivery and Therapeutic Efficacy
In recent years, bioconjugation has emerged as a powerful strategy for improving drug delivery and enhancing therapeutic efficacy. By linking drugs to various biological entities, such as proteins, antibodies, nanoparticles, or targeting moieties, bioconjugation enables precise and targeted delivery of therapeutic agents to desired sites. This article aims to provide an overview of different ...
By BOC Sciences
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Unraveling the IL-17 Family and its Receptor Complex: Key Players in Immune Responses
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli ...
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Exploring the Multifaceted Applications of Ox Bile Extract Powder
Introduction: Ox bile extract powder, derived from ox bile, is a natural product with a wide range of applications. It contains essential components such as bile acids, cholesterol, bilirubin, and fatty acids. Through meticulous preparation processes, it is transformed into a powdered form, enhancing its stability and convenience. Ox bile extract powder exhibits diverse applications in the fields ...
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Glucose metabolism: key to neurodegenerative diseases
Previously, it was thought that glial cells, which support neuronal activity, metabolize most of the glucose in the brain. However, by using induced pluripotent stem cells, the researchers found that neurons were able to take up glucose and process it into smaller metabolites. In mice, normal function of neurons depends on glycolysis. The findings could help develop new treatments for ...
By CD BioGlyco.
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Monoaromatic Heterocyclic Chemistry: Applications and Synthesis
Summary Heterocyclic compounds with aromatic characteristics are called aromatic heterocyclic compounds, which can be classified into monoaromatic heterocycles and fused heterocycles. The common monoaromatic heterocycles are five-membered Furan, Pyrrole, Thiophene, Pyrazole, Imidazole, Oxazole, etc., and six-membered Pyridine, Pyranone, Pyridazine, Pyrimidine, Triazine, etc. Aromatic ...
By BOC Sciences
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Rho kinase inhibition in Amyotrophic Lateral Sclerosis - Case Study
REAL is a phase 2a open-label study to assess preliminary safety, tolerability, and effect on clinical outcomes as well as neurodegeneration biomarkers of BRAVYL in patients with ALS. The study will enroll approximately 20 patients, all of whom will be treated with BRAVYL for 24 weeks. ...
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Project - Sublingual IL2 (BL SLIT I)
The aim of this project is to develop low dose IL-2 for treatment of early onset juvenile Type I diabetes. Low dose injectable IL-2 in animal models has been shown to restore the balance between regulatory and effector T cells and, in this way, can help to reverse autoimmunity and the development of type I diabetes. Looking ahead, we anticipate that having a suitable oral formulation of IL-2 to ...
By BioLingus AG
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Feature Signature Discovery for Autism Detection: An Automated Machine Learning Based Feature Ranking Framework - Case Study
Abstract Autism spectrum disorder is the most used umbrella term for a myriad of neuro-degenerative/developmental conditions typified by inappropriate social behavior, lack of communication/comprehension skills, and restricted mental and emotional maturity. The intriguing factor of this disorder is attributed to the fact that it can be detected only by close monitoring of developmental milestones ...
By JADBio
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SpinTech MRI Earns FDA 510(k) Clearance for Rapid, Quantitative Brain-Imaging Technology
The US Food and Drug Administration (FDA) has given 510(k) clearance to SpinTech MRI’s latest magnetic resonance imaging software device, STAGE (STrategically Acquired Gradient Echo), a post-processing software platform that enables comprehensive, quantitative brain imaging with enhanced visualization in significantly less time than conventional approaches. STAGE allows MRI ...
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The Future of Quantitative Susceptibility Mapping (QSM) in Clinical Applications
The use of Quantitative Susceptibility Mapping (QSM) is often viewed as incompatible with current standard radiology workflows. Some radiologists or departments may be unaware of its existence or purpose. Despite the skepticism surrounding its viability in a clinical setting, QSM shows great potential in a wide range of clinical applications, particularly for biomarker detection and ...
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Do you really have to sacrifice MRI image quality for speed?
To understand the significance of the SpinTech MRI STAGE software platform, it helps to begin by asking a question: Given that MRI is an incredibly powerful diagnostic tool for neurological diseases like Alzheimer’s, dementia, Parkinson’s and multiple sclerosis (MS), why have radiologists and neurologists had to choose between conducting faster MRI exams and obtaining higher-quality ...
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Applications of 16S/18S/ITS Amplicon Sequencing
16S/18S/ITS amplicon sequencing has now been a well-established method. Due to its low cost, shorter cycle and low quality requirement of the sample, 16S/18S/ITS amplicon sequencing is widely used in the study of microorganisms. 16S/18S/ITS amplicon sequencing reveals the species of microorganisms in environmental samples and their differences, relative abundance, population structure and ...
By CD Genomics
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Computer Vision for Medical and Healthcare Imaging Solutions
There are a ton of practical uses for computer vision at present times. One industry where this technology is increasingly useful in healthcare. It is impossible to exaggerate the value of computer vision services in the medical field. Its methods continue to be used more widely since they have demonstrated excellent utility in numerous medical contexts, including surgical planning and medical ...
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