Advanced Lung Function Measurement In A Novel HIV/Tuberculosis Co-Infection Mouse Model

Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) are major global health threats. Their interaction worsens disease severity, as HIV reduces CD4+ T cells, making individuals more vulnerable to TB. Despite progress, an effective animal model that mimics human immune response during HIV/TB co-infection has been lacking, hindering treatment and vaccine development.

Bohorguez et al. (2024) developed a humanized NSG-SGM3 mouse model to advance HIV/TB co-infection studies. These mice are transplanted with human CD34+ stem cells, enabling the development of various human immune cells. This model allows researchers to study CD4+ T cell depletion and HIV viral load, closely replicating human infection.