AlveoliX part of a new BRIDGE Discovery project
We are thrilled to be part of the new BRIDGE Discovery project granted by the SNSF Swiss National Science Foundation and Innosuisse to the Laboratory of Microbiology at the Université de Neuchâtel (LAMUN) in cooperation with the CHUV / Centre hospitalier universitaire vaudois, the SIB Swiss Institute of Bioinformatics, and SiMPLInext SA.
The project led by Prof. Pilar Junier aims at establishing a novel solution to the burden imposed by raising antibiotic resistance by applying the innovative concept of “environmental interference” to human health for the first time to fight lung fungal infection.
The Swiss National Science Foundation SNSF and the Swiss Innovation Agency Innosuisse have granted a BRIDGE Discovery project to the Laboratory of Microbiology at the University of Neuchâtel (LAMUN) in cooperation with the Centre Hospitalier Universitaire Vaudois (CHUV), the Swiss Institute of Bioinformatics (SIB), and two innovative Swiss
startups AlveoliX AG and SiMPLInext SA. The aim of this project is to demonstrate for the first time the applicability of ecological theory (initially applied in the field of soil sciences) to human health, as a sustainable mean to fight fungal infection inside the lungs. There is a pressing need to establish novel approaches to treat these life-threatening pathogens due to the emergence of resistance against existing drugs.
Innovative approach In this project we will apply an entirely new approach called « environmental interference » to
fight fungal infection. It exploits the ecology of the lung microbiota by using airway bacteria with the aim to alter the lung microenvironment to fight the lung infection by stopping the proliferation of fungi.
The goal of this project is to develop a highly predictive preclinical testing platform. It will be based on in vitro, advanced in vitro (lung-on-chip), in vivo and in silico models, to isolate suitable bacteria. We will also create a bioinformatic tool allowing the screening of the lung microbiome of patients to identify at-risk groups and to promote early intervention
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