Camurus announces dosing initiated in Phase 3 study of CAM2029 in patients with neuroendocrine tumors

Camurus (NASDAQ STO: CAMX) today announces that dosing has been initiated in the company’s randomized, active-controlled Phase 3 study, SORENTO, which aims to evaluate the efficacy and safety of octreotide subcutaneous depot (CAM2029) in the treatment of patients with neuroendocrine tumors localized in the gastrointestinal tract or pancreas (GEP-NET).

“There is a high unmet medical need for new treatment alternatives for patients with neuroendocrine tumors. I am excited about the SORENTO trial, which primarily aims to demonstrate an increased progression-free survival with product candidate CAM2029 compared to currently available standard medical treatments”, says Coordinating Investigator for the study Dr Simron Singh, Medical Oncologist at the Susan Leslie Clinic for neuroendocrine cancers, Odette Cancer Center, Sunnybrook Health Sciences center, Toronto, Canada, and Associate Professor at the University of Toronto. “This trial allows the possibility of self-administration and is part of the global movement to increased patient empowerment and patient centered care.”

The SORENTO study will include approximately 300 patients with metastatic and/or unresectable GEP-NET. Patient recruitment is planned to be completed by the end of 2022, with results from the randomized part of the study expected by end of 2024.

Treatment with somatostatin analogues, such as octreotide and lanreotide, is currently clinical standard practice in the medical treatment of patients with advanced and well-differentiated GEP-NET. Clinical studies have demonstrated that an enhanced octreotide exposure, significantly higher than currently approved treatment doses, has the potential to reduce tumor growth and symptoms in patients with GEP-NET.^1,2