CD BioGlyco Released Separation of Glycosaminoglycans Service Recently

CD BioGlyco, a biotechnology company that provides glycobiology-related products, analysis, custom synthesis, and design to advance glycobiology research, recently announced the release of separation of Separation of Glycosaminoglycans service to the science community.

Glycosaminoglycans, once known as mucopolysaccharides, are mainly found in the connective tissues of higher animals and plants. Glycosaminoglycan (GAG) is a large linear polysaccharide composed of repeating disaccharide units. Its main configuration contains amino sugars (GlcNAc or GalNAc) and uronic acids (glucuronic acid and/or iduronic acid). GAG can be divided into two types: (a) glucosaminoglycans, including hyaluronic acid (HA), keratan sulfate (KS), heparan sulfate (HS), and heparin; and (b) galactosaminoglycans, including chondroitin and dermatan sulfate (CS/DS). With the exception of KS and HA, all GAGs are linked to their parental proteins by xylose-galactose-galactose-glucuronic acid core tetrasaccharide (GlcAb1-3Galb1-3Galb1-4Xylb1-O-Ser).

GAG accounts for a significant fraction of glycoconjugates in the extracellular matrix of cell membranes and almost mammalian tissues. Their ability to bind and alter protein-protein interactions or enzyme activity has dramatically influenced our understanding of many biological processes, including cell proliferation, differentiation, wound infection, and healing. It is also an important co-factor for a variety of cellular behaviors.

At present, CD BioGlyco has various advanced technology platforms and analysis tools that help customers study glycosaminoglycans in depth. Services to isolate and purify high-quality GAG from various samples such as cells or tissues are provided by CD BioGlyco. And the company can also perform subsequent GAG profiling as needed.

Listed below are the separation process provided by CD BioGlyco:

The degradation of the core protein must be inhibited before purification.

A combination of a variety of separation methods (including organic solvent precipitation, fractionation, ultracentrifugation, ion-exchange chromatography and size-exclusion chromatography, etc.) are used to separate GAG from other proteins

“We have accumulated abundant experience in the separation and profiling of glycosaminoglycans. We have confidence to be your essential research assistant in the field of glycobiology.” Commented Anna, the official speaker from CD BioGlyco.

If you feel interested and want to know more about the separation of glycosaminoglycans service provided by CD BioGlyco, please visit https://www.bioglyco.com/glycosaminoglycans-separation.html.