Circassia Announces Duaklir US Launch at American College of Chest Physicians’ CHEST Annual Meeting 2019

Circassia Pharmaceuticals plc (“Circassia” or “the Company”; LSE: CIR), a specialty pharmaceutical company focused on respiratory disease, today announces the US launch of Duaklir® for the maintenance treatment of chronic obstructive pulmonary disease (COPD) at the American College of Chest Physicians’ CHEST Annual Meeting 2019, which is currently ongoing in New Orleans, LA.

Duaklir® is a fixed-dose LAMA / LABA combination of the long-acting muscarinic antagonist (LAMA) aclidinium bromide and long-acting beta-agonist (LABA) formoterol fumarate administered twice-daily via the breath-actuated, multi-dose inhaler Pressair®. Circassia will promote Duaklir® in the United States via its dedicated COPD sales force, alongside its established COPD treatment Tudorza® (aclidinium bromide).

Duaklir® has been approved by the United States Food and Drug Administration based on a broad clinical database. This includes data from three phase III studies, ACLIFORM, AUGMENT and AMPLIFY, and the phase IV ASCENT study, which shows aclidinium therapy is effective at reducing COPD exacerbations.  As part of its Duaklir® launch activities at the CHEST Annual Meeting 2019, Circassia hosted a Respiratory Educational Reception.  This brought together posters presented at major scientific meetings in the United States and Europe detailing results from the AMPLIFY and ASCENT studies.

About COPD
COPD (chronic obstructive pulmonary disease) is a progressive life-threatening lung disease associated primarily with tobacco smoke, with other risk factors including exposure to air pollution or occupational dusts and fumes. The most common symptoms of COPD are breathlessness, chronic cough and mucous production. COPD causes serious long-term disability and early death, and the number of people dying from the disease is growing. According to the American Lung Association, more than 11 million people have been diagnosed with COPD and it is the third leading cause of death from disease in the United States.

About Circassia
Circassia is a world-class specialty pharmaceutical business focused on respiratory disease. The Company sells its market-leading NIOX® asthma management products directly to specialists in the United States, United Kingdom, China, Germany and Italy, and in a wide range of other countries through its network of partners.  In the United States, Circassia has the commercial rights to chronic obstructive pulmonary disease (COPD) treatments Tudorza® and Duaklir®.  Circassia also has the US and Chinese commercial rights to the late-stage ventilator-compatible nitric oxide product LungFit PH.