Covid-19 vaccine candidates using SpyCatcher/SpyTag to display Spike protein on computationally designed particles and Bacteriophage VLPs

 recent papers with really interesting results!

Click here to read the full paper on computationally designed VLPs.

Results:

1. RBD can be efficiently displayed on the mi3 VLP via SpyTag/SpyCatcher
2. RBD-SpyVLP is reactive to monoclonal antibodies isolated from recovered patients 
3. RBD-SpyVLP induces a strong ACE2-blocking and neutralising antibody response in mouse models
4. RBD-SpyVLP is highly immunogenic and induces strong neutralising antibody response in pigs

Click here to read the full paper on Bacteriophage VLPs.