SOPHiA Genetics

ECP Posters spotlight

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Oct. 13, 2024- By: Marinela Lekka
Courtesy ofSOPHiA Genetics
In this piece, we talked to the two presenters of the poster “The Validation of a Homologous Recombination Deficiency Assay into Clinical Practice within the NHS”, Elizabeth Ratsma, Pre-Registration Clinical Scientist – Cancer Genomics and Charlotte Flanagan, PhD, Innovation Lead, from The Royal Marsden NHS Foundation Trust. The poster was recently presented at the ESMO Gynaecological Cancers Congress 2024 in Florence, Italy. Read the full spotlight:

We recently presented two posters at the European Congress of Pathology 2024, in Florence, Italy, in collaboration with Janssen Pharmaceutical, a Johnson & Johnson company.

The posters provided real-world data insights on the genomic landscape of specific biomarkers associated with lung and prostate cancers, in a subset of European countries.

The first poster spotlight features Stefano Cheloni, Senior Bioinformatician – Tertiary Analysis at SOPHiA GENETICS, presenting the poster titled: “Real-world insights from France, Italy, Spain, and Austria for the investigation of common (exons 19,21) and rare (exons 18, 20) EGFR mutations in lung cancer”.

The identification of exon-specific EGFR mutations can guide the appropriate treatment of lung cancer with tyrosine kinase inhibitors (TKIs) or alternative targeted therapies. This project aimed to explore the landscape of next-generation sequencing (NGS) testing practices for EGFR mutations in clinical practice in a subset of European countries, to determine the potential number of individuals with lung cancer that could benefit from treatment with TKIs or alternative targeted therapies.

Watch the spotlight below:

To see video, please click here

In our second poster spotlight, Adrian Janiszewski, Manager Bioinformatician – Team Lead Tertiary Analysis at SOPHiA GENETICS, showcases a poster titled: “NGS testing practices and molecular profiles of BRCA1/2 in prostate cancer: Real-world insights from France, Italy, Spain, and Austria”.

BRCA1/2 testing can inform which prostate cancer patients might respond to PARP inhibitors (PARPi). Having a better understanding of BRCA1/2 testing practices in the real-world setting can provide valuable insights into identifying gaps and opportunities to improve the identification of metastatic prostate cancer (mPC) patients who may benefit from PARPi treatment. In this study we investigated NGS testing practices results across specific European countries.

Watch the spotlight below:

To see video, please click here

We would like to warmly thank Stefano and Adrian for their insightful presentations and for sharing the key takeaways of these projects.

Learn more about SOPHiA DDM™ for BioPharma, by visiting the page.

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