cancer News
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A Phase Ii Trial Of Onapristone In Combination With Fulvestrant For Patients With Er-Positive And Her2-Negative Metastatic Breast Cancer After Progression On Endocrine Therapy And Cdk 4/6 Inhibitors
Antiprogestins act as Progesterone Receptor (PgR) antagonists. Novel and promising class of drugs to overcome endocrine resistance associated with ESR1 mutations. SMILE STUDY is a multi-institutional phase II clinical trial to determine the efficacy of an antiprogestin, Onapristone +fulvestrantas second line therapy for patients with HR+/HER2- metastatic breast cancer (MBC). Hypothesis: The ...
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ctDNA-guided Adaptive Therapy Escalation in ER+ MBC: A Phase 1b Study with Letrozole, Palbociclib and Onapristone ER
Extended release Onapristone (Onapristone ER) is a progesterone receptor (PR) antagonist that inhibits hormone-mediated PR activation and stabilizes PR association with compressors, resulting in an antineoplastic effect when applied alone or in combination with antiestrogen therapy to breast cancer cells in vitro (1). Recent preclinical studies further suggest that onapristone adds to inhibition ...
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Onapristone Extended Release: Safety Evaluation from Phase I–II Studies with an Emphasis on Hepatotoxicity
Introduction Anliprogestins have demonstrated promising activity against breast and gynecological cancers, but liver-related safety concerns limited the advancement of this therapeutic class. Onapristone is a full progesterone receptor antagonist originally developed as an oral contraceptive and later evaluated in phase II studies for metastatic breast cancer. Because of liver enzyme elevations ...
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Northern Arizona, Verde Valley MC Highlights VeraForm; Importance Marking Breast Surgical Site
As a patient facing breast cancer surgery, you should know that precise "marking" of your cancer surgical site is an important part of your treatment. A marker is a device inserted at the surgical site. Precision in marking helps make sure you retain as much normal breast tissue as possible with the surgery. This ultimately leads to best overall post-surgical care by your wellness team. A new ...
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Call for the French Cancer Plan to recognise environmental factors
In February, the Health & Environment Alliance (HEAL) and the Mouvement pour les Droits et le respect des Générations Futures (MDRGF) coordinated a petition to call for the inclusion of environmental factors, such as pesticides exposure within the new French Cancer Plan something that was overlooked in the previous plan. This cyber action was organized in the framework of HEAL and MDRGF 'Sick ...
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VMI Raises more than 86,000 Euro with Stelvio for Life
A team of 47 VMI colleagues from Epe and Leszno participated in the Stelvio for Life challenge on Saturday, September 3rd. With this, they raised over 86,000 Euros in the fight against cancer. VMI Raises Funds for Cancer Charity Each year, VMI participates in a challenging sporting event to raise money for charity. After 2 years of not being able to participate in such a fund aising event, the ...
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Mobile Mammography
bout two years after the outbreak of COVID-19, many resources are still being used in the fight against this new virus. Nevertheless, the number of breast cancer cases in Italy are still very high: according to the report “The numbers of cancer in Italy”, published by AIRTUM and AIOM, in 2020 about 55.000 new cases were diagnosed in Italy among women (as of today, estimates for 2021 ...
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Southwest airlines supports families facing serious illness
Southwest Airlines and a Special Journey For John You probably wouldn’t know it by looking at him, but John, a father of three and husband to Lynn, is battling cancer. Take the stresses of everyday life: getting the kids to school on time, paying the bills, keeping the family generally happy and healthy. Then, top that with cancer. Now you’re in John’s world. It’s not ...
By 3BL Media
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Bertin Technologies teams support the fight against breast cancer
This month, from Frankfurt to Finland via Montigny-le-Bretonneux, Bertin Technologies Group employees around the world took part in “Pink October”, a month dedicated to prevention, information and fundraising in the fight against breast cancer. In addition to raising awareness of this disease by wearing a touch of pink, our colleagues in Basingstoke (UK) organized a collection and ...
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OSHwiki article in the spotlight: call for policies to eliminate occupational cancer
A new OSHwiki article approaches the subject of occupational cancer with the premise that such cancers can be tackled because exposure to causing/facilitating factors can be reduced or eliminated. Cancer accounts for 53 % of all occupational deaths in the EU and in 2011 this figure totalled 102 500 deaths. Lung cancer is the biggest culprit, accounting for 54-75 % of all occupational ...
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Summary report - Exposure to carcinogens and work-related cancer: A review of assessment methods
Estimates of the recent and future burden of occupational diseases indicate that occupational cancer is still a major problem and will remain so in the future as a result of exposure of workers to carcinogens. That's why occupational cancer is a problem that needs to be tackled across the European Union. This summary provides a short overview of assessment tools for the exposure to cancer risk ...
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IONIQ Sciences announces IP acquisition and License buyou
ProLung, Inc. dba IONIQ Sciences, Inc. (“IONIQ” or the “Company”) announced today that it has acquired from OT Acceptance, LLC (“OT Acceptance”) certain intellectual property formerly licensed to the Company by OT Acceptance. With this acquisition, the Company now owns (rather than licenses) all of the intellectual property used by it with respect to early ...
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Stelvio Oncology featured in Popping the Bubbl
Great conversation with Pete Turner and Sandra Ponce de Leon bringing to light how we are discovering novel cancer therapeutics with our innovative ...
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JPM Biotech Showcase Presentation
Reglagene's CEO Richard Austin presented at JPM #BiotechShowcase this afternoon. This was a very exciting presentation as Richard announced the selection of Reglagene's Clinical Candidate for brain ...
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Hanukkah marks the start of the gift-giving season - All4One Alliance has the perfect gift
With the holiday gift-giving season officially under way, don't miss your chance to order a great gift for all the women on your list – the 2011 Show Us Your BRA!™ Calendar. This unique wall calendar features “bra-art” designs by celebrities including singer, India.Arie and model, Emme, as well as local artists. The original, often-humorous bra-art images are accompanied ...
By 3BL Media
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2nd PhD student appointed to the Toxicity Atlas project
We are very happy to welcome Ghislaine Deutsch as the second PhD student working on the Toxicity Atlas! In the Toxicity Atlas project, Medstoner Silvia Scoarta, VUmc professor Bart Westerman, and their team are researching better ways to treat brain cancer. Quite the task! Ghislaine’s expertise in biology and bio-informatics will make a great contribution to the project by, among other ...
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Symberix Co-Founder Gives Keynote Address at AACR Conference
Symberix co-founder Matthew Redinbo gave the keynote address at the AACR Microbiome, Viruses, and Cancer conference on Friday, February 21, 2020. The special conference covers the contribution of bacterial, viral, and fungal pathogens to the development of cancers, as well as the impact of the microbiome on cancer therapy. Dr. Redinbo’s keynote, titled “Molecular control of the gut ...
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The perfect last-minute gift idea
Don’t hit the panic button if you’re still looking for a few more gifts – the 2011 Show Us Your BRA!™ Calendar is a great last-minute gift. This unique wall calendar features “bra-art” designs by celebrities including singer, India.Arie and fashion designer, Rebecca Minkoff, as well as local artists. The original, often-humorous bra-art images are accompanied ...
By 3BL Media
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The perfect gift for new beginnings – a 2011 calendar that benefits breast cancer survivors
Looking to help someone start the New Year right? The 2011 Show Us Your BRA!™ Calendar is the perfect gift for new beginnings. This unique wall calendar features “bra-art” designs by celebrities including singer, India.Arie and fashion designer, Rebecca Minkoff, as well as local artists. The original, often-humorous bra-art images are accompanied by inspirational quotes and ...
By 3BL Media
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NeoTherma Oncology Opens Clinical Study - Wichita, Kansas
NeoTherma Oncology, having achieved both FDA approval for its Investigational Device Exemption for an Early Feasibility Study of the VectRx™ System and institutional review board approval at an east coast National Cancer Institute-designated Cancer Center, has initiated recruitment for a first-in-human trial in patients with pancreatic ...
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