Cytokine Membrane Articles & Analysis: Older
2 news found
Armoring cell therapies with potent cytokines such as IL12 is a promising approach to treating solid tumors, but uncontrolled constitutive expression of these payloads has limited their clinical use due to toxicity. ...
Specifically, the authors outline the benefits of calibrated release gene circuit technology, which combines the advantages of secreted and membrane-tethered cytokine-mediated stimulation of the patient’s immune system, to better control solid tumors. ...