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Drug Evaluation Articles & Analysis
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Developing effective treatments for IPF has been a challenge for the medical community, as the mechanisms driving this disease are complex and not fully understood. To accelerate drug discovery, animal models that closely mimic the human disease are crucial. In this context, a recent study by Petersen et al (2024) has made significant strides in validating a well-known IPF mouse ...
The process of antipsychiatric drug development typically involves several stages, including identifying potential drug targets, conducting preclinical research to test the safety and efficacy of potential drug candidates, and then moving on to clinical trials to further evaluate the drug’s effectiveness ...
“Our extensive portfolio covers a range of pharmacological services essential for the intricate process of veterinary drug development. By offering tailored solutions in pharmacodynamics, pharmacokinetics, toxicology, and consistency evaluation, we endeavors to addresses the multifaceted challenges faced by veterinarians and researchers,” said the ...
By conducting comprehensive efficacy evaluations using CD Formulation's advanced formulation techniques, pharmaceutical companies can streamline the drug development process and bring novel treatments to market more efficiently. In addition to enhancing the evaluation of oral thin films, CD Formulation's formulation technology also has the ...
Microneedles have emerged as groundbreaking technology in the field of drug delivery, providing a more efficient and painless way of administering medicines. ...
These services encompass cell-level screening, identification of cell lines and models, genotyping services for rats and mice, PET-CT services, and flow cytometry services. Drug Safety Evaluation Services One of the core services offered by Alfa Chemistry is drug safety evaluation. This critical step in the drug ...
This cutting-edge technology provides scientists and researchers with an innovative platform to study human organs in a way that was previously impossible, promising to accelerate drug discovery, reduce the need for animal testing and ultimately transform the future of medicine. ...
About the TORCH-2 Trial The TORCH-2 trial (NCT04337463) was designed to evaluate the safety and efficacy of ATG-008 combined with toripalimab (PD-1 antibody) in subjects with advanced solid tumors. ...
In the process of drug development, the evaluation of drug effectiveness is one of the keys to determining whether prodrugs can sufficiently reach the market stage. ...
Bayer recently received U.S. Food and Drug Administration (FDA) approval for darolutamide in combination with docetaxel in mHSPC patients and has submitted applications in mHSPC to the European Medicine Agency (EMA), the Ministry of Health, Labour and Welfare (MHLW) in Japan, and China’s Center of Drug Evaluation (CDE). ...
ByBayer AG
Multicenter Phase 1 study to evaluate IO-108 as both monotherapy and in combination with pembrolizumab in China Represents the first LILRB2-targeting antibody with IND clearance in China and the company’s fourth IND globally A Phase 1 trial evaluating IO-108 in patients with advanced solid tumors is currently enrolling in the U.S. ...
Bayer today announced the U.S. Food and Drug Administration (FDA) has accepted a supplemental New Drug Application (sNDA) and granted Priority Review for the oral androgen receptor inhibitor (ARi) darolutamide in combination with docetaxel for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). ...
ByBayer AG
Frontier Biotech (stock code: 688221.SH) announced that the Phase II/III clinical study protocol of FB2001 (generic name: Bofutrelvir) is approved by the Center for Drug Evaluation, NMPA. The study is a worldwide multi-center, randomized, double-blind and placebo-controlled Phase II/III trial to evaluate the safety and efficacy of Bufutrelvir for ...
As in the previous study announced in November 2021, the BIT225 treated mice once again had significantly lower viral loads of SARS-CoV-2 in their lungs compared to drug free control animals. BIT225 belongs to a new class of antiviral drugs known as viroporin inhibitors. ...
Profacgen, a state-of-the-art protein service provider located in the USA, provides comprehensive one-stop services for pre-clinical drug development, aiming to evaluate and improve the efficacy and safety of new drug candidates. ...
” KORSUVA™ (difelikefalin) injection was approved by the U.S. Food and Drug Administration in August 2021 for the treatment of moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis. ...
Pronalyse is a new division of Creative Proteomics, which is an integrated CRO with rich experience in providing drug development services for over 10 years. To assist customers in understanding the changes in protein charge heterogeneity throughout manufacturing and purification, Creative Proteomics Pronalyse offers antibody drug charge variant analysis services ...
The new capital will be used to expand Immunai’s “drug actuary” platform for target validation and evaluation. “We have made great progress towards our core mission of understanding the immune system, which we believe is essential to finding the answers to human health and disease,” said Noam Solomon, PhD, CEO and co-founder of ...
ByImmunai
We are now taking the next major step toward realizing the potential of our innovative gut-targeted therapeutic approach by evaluating AB-2004 in a multi-national, randomized, placebo-controlled Phase 2b trial, which we have just ...
As excessive amounts of water will adversely affect the physical and chemical stability of the API and the functionality of the excipients, determining hygroscopicity is therefore a very critical step, especially for drugs that degrade greatly in the presence of water. “Usually, moisture absorption evaluations start from the early stages of ...