Drug Exposure Articles & Analysis
6 news found
Lenalidomide has been an effective immunomodulatory drug in hematologic malignancies for years, however adverse events, notably neutropenia, have limited its use in certain patient settings. ...
Shanghai Ruijin Hospital recently announced that it has initiated an investigator-initiated clinical trial (IIT) to evaluate the safety and efficacy of Bofutrelvir administered by inhalation for post-exposure prophylaxis in close contacts of COVID-19 (NCT05415241). It is a single-arm, open-label, multi-dose exploratory clinical study with an enrolment of ~60 subjects who are ...
Results from initial CY6463 clinical studies have demonstrated favorable safety and tolerability and pharmacologically relevant drug exposure in the cerebral spinal fluid. Furthermore, promising impacts on EEG measures, neuroinflammation, and other measures support the current clinical development of CY6463. ...
Evaluation of antiprogestin pharmacology and pharmacokinetic data suggested that liver enzyme elevations might be related to off-target or metabolic effects associated with clinical drug exposure. Objective We explored whether the use of a pharmaceutic strategy targeting efficacious systemic dose concentrations, but with diminished peak serum concentrations ...
“This study, in addition to several of our other recent studies,” Clarke says, “shows that NASH, either alone or in combination with genetic differences in drug transporters, can have a profound effect on drug exposure.” Cherrington notes that this study is about the mechanism explaining how NASH changes the body’s ...
According to a new survey commissioned by Seventh Generation, the nation"s leading brand of environmentally responsible household and personal care products, half of all parents surveyed expressed more concern for the spread of germs (51 percent) than exposure to drugs/alcohol (28 percent) and poor grades (45 percent). The Seventh Generation Back to School ...