Melanoma Model Articles & Analysis
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The data to be presented demonstrate significantly greater anti-tumor activity of cytoTIL15 therapy in vivo compared to conventional TIL + IL2 therapy in a human leukocyte antigen (HLA)-matched, allogeneic patient-derived xenograft (PDX) melanoma model, including greater persistence of cytoTIL15 cells in blood and lymphoid organs, superior tumor growth inhibition ...
They show in breast cancer that there are frequent intron splicing errors that, if translated, would create frameshift peptides. Mouse tumor models for melanoma and breast cancer revealed these frameshift neoantigens conferred partial protection as vaccines. ...
ByCalviri